Is FUCOXANTHIN safe to use in EU cosmetics?

FUCOXANTHIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 3351-86-8?

CAS 3351-86-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8642815/10/2010

FUCOXANTHIN

beta,beta-Carotene, 3'-(acetyloxy)-6',7'-didehydro-5,6-epoxy- 5,5',6,6',7,8-hexahydro-3,5'-dihydroxy-8-oxo-, (3S,3'S,5R,5'R,6S,6'R)-

FUCOXANTHIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 3351-86-8

CAS 3351-86-8PubChem CID 5281239

Fucoxanthin

Fucoxanthin is an epoxycarotenol that is found in brown seaweed and which exhibits anti-cancer, anti-diabetic, anti-oxidative and neuroprotective properties. It has a role as a hypoglycemic agent, a hepatoprotective agent, a neuroprotective agent, a CFTR potentiator, an apoptosis inhibitor, a marine metabolite, a plant metabolite, a food antioxidant and an algal metabolite. It is a tertiary alcohol, an epoxycarotenol, a secondary alcohol, a member of allenes and an acetate ester. — ChEBI

IUPAC name: [(1S,3R)-3-hydroxy-4-[(3E,5E,7E,9E,11E,13E,15E)-18-[(1S,4S,6R)-4-hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl]-3,7,12,16-tetramethyl-17-oxooctadeca-1,3,5,7,9,11,13,15-octaenylidene]-3,5,5-trimethylcyclohexyl] acetate

Molecular formula: C42H58O6
Molecular weight: 658.9 g/mol
Exact mass: 658.42333957 Da
XLogP3: 8.1
Topological polar surface area: 96.4 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 5

Also known as

all-trans-Fucoxanthin06O0TC0VSMCHEBI:5186(3'S,5'R,6'R)-3'-acetoxy-5,6-epoxy-3,5'-dihydroxy-6',7'-didehydro-5,6,7,8,5',6'-hexahydro-beta,beta-caroten-8-one(3S,5R,6S,3'S,5'R,6'R)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,6-epoxy-5,6,7,8,5',6'-hexahydro-beta,beta-caroten-3'-yl acetate(3S,3'S,5R,5'R,6S,6'R)-3'-(acetyloxy)-6',7'-didehydro-5,6-epoxy-5,5',6,6',7,8-hexahydro-3,5'-dihydroxy-8-oxo-beta,beta-caroteneFucoxanthin, all-trans-CCRIS 4055

16 more reported names

C42H58O6UNII-06O0TC0VSMBRN 0073179Fucoxanthine.alpha.-Carotene, 6',7'-didehydro-5,6-epoxy-4',5,5',6,7,8-hexahydro-3,3',5'-trihydroxy-8-oxo-, 3'-acetate, all-trans-(all-E)-fucoxanthinFucoxanthine - 10%Fucoxanthine - 50%Fucoxanthin (Standard)FUCOXANTHIN [MI]FUCOXANTHIN [WHO-DD]5-18-04-00673 (Beilstein Handbook Reference)Fucoxanthin, analytical standardHY-N2302RSJWWTRQNNRNTPU-ABBNZJFMSA-SJWWTRQNNRNTPU-ABBNZJFMSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:5186
ChEMBL:CHEMBL1575074
EPA DTXSID:DTXSID901031617
PubMed:9438
PubMed:5582

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for FUCOXANTHIN

INCI name

FUCOXANTHIN

Description

beta,beta-Carotene, 3'-(acetyloxy)-6',7'-didehydro-5,6-epoxy- 5,5',6,6',7,8-hexahydro-3,5'-dihydroxy-8-oxo-, (3S,3'S,5R,5'R,6S,6'R)-

Record provenance

Inventory reference: 86428
Imported identity: FUCOXANTHIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for FUCOXANTHIN

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Key data

CAS

3351-86-8

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10671 · FUCOXANTHIN

Ingredients with overlapping formulation functions

FUCOIDANANTIOXIDANT, SKIN CONDITIONING

FUCOSESKIN CONDITIONING

FUCOSTEROLANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

FUCOSYLLACTOSESKIN CONDITIONING, SKIN PROTECTING

FUCUS SPIRALIS EXTRACTSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

FUCUS VESICULOSUSSKIN CONDITIONING

FUCUS VESICULOSUS EXTRACTSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SMOOTHING, SOOTHING

FUCUS VESICULOSUS POWDERSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How FUCOXANTHIN appears in the CosIng inventory

The CosIng inventory lists FUCOXANTHIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

FUCOXANTHIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

FUCOXANTHIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, FUCOXANTHIN carries the following function designation(s):

SKIN CONDITIONING

CAS 3351-86-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for FUCOXANTHIN

This page reproduces the CosIng inventory entry for FUCOXANTHIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research FUCOXANTHIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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