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CAS 27025-41-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8510215/10/2010

OXIDIZED GLUTATHIONE

bi(glutathion-S-yl)

OXIDIZED GLUTATHIONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 27025-41-8

CAS 27025-41-8PubChem CID 65359

Glutathione Disulfide

Glutathione disulfide is a glutathione derivative and an organic disulfide. It has a role as a mouse metabolite and an Escherichia coli metabolite. It is a conjugate acid of a glutathione disulfide(2-). — ChEBI

IUPAC name: (2S)-2-amino-5-[[(2R)-3-[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]disulfanyl]-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Molecular formula: C20H32N6O12S2
Molecular weight: 612.6 g/mol
Exact mass: 612.15196282 Da
XLogP3: -9.1
Topological polar surface area: 368.0 Å²
Hydrogen-bond donors: 10
Hydrogen-bond acceptors: 16
Covalent units: 1
Defined stereocentres: 4

Also known as

GSSGGlutathione disulphideOxigluthioneGlutathone disulfideOxiglutationaOxiglutationumBis(gamma-glutamyl-L-cysteinylglycine) disulfideULW86O013H

16 more reported names

Disulfide, GlutathioneRefChem:570552-amino-4-((2-((2-(4-amino-4-carboxybutanamido)-2-((carboxymethyl)carbamoyl)ethyl)disulfanyl)-1-((carboxymethyl)carbamoyl)ethyl)carbamoyl)butanoic acidoxiglutationeGlutathione-ssgOxiglutatione [INN]Bi(glutathion-S-yl)Oxiglutationum [INN-Latin]Oxiglutationa [INN-Spanish]CCRIS 780121-24-4N-(N-gamma-Glutamyl-cysteinyl)glycine-(2,2)-disulfideGlutathione oxidized formGlutamine, N,N'-(dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-, L-Glycine, L-gamma-glutamyl-L-cysteinyl-, (2,2')-disulfideGlutathione EP Impurity C

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17858
ChEMBL:CHEMBL1372
EPA DTXSID:DTXSID5048972
PubMed:41998286
PubMed:35204234
PubMed:32165127
PubMed:31957488
PubMed:31909875
PubMed:31288001
PubMed:30242128
PubMed:28478275
PubMed:28238931
PubMed:27847271
PubMed:27424009
PubMed:24634002

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for OXIDIZED GLUTATHIONE

INCI name

OXIDIZED GLUTATHIONE

Description

bi(glutathion-S-yl)

Record provenance

Inventory reference: 85102
Imported identity: OXIDIZED GLUTATHIONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for OXIDIZED GLUTATHIONE

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Key data

CAS

27025-41-8

248-170-7

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN CONDITIONING - EMOLLIENT: Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#18521 · OXIDIZED GLUTATHIONE

Ingredients with overlapping formulation functions

OSTRICH EGG YOLK EXTRACTANTIMICROBIAL, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

OSTRYA JAPONICA LEAF EXTRACTANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

OVUM OILSKIN CONDITIONING - EMOLLIENT

OXALIS HEDYSAROIDES OILSKIN CONDITIONING - EMOLLIENT

OXIDIZED TALL OIL ACIDS/NEOPENTYL GLYCOL COPOLYMERFILM FORMING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING

OXYCOCCUS PALUSTRIS SEED OILANTIOXIDANT, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

OYSTER STEROLSSKIN CONDITIONING - EMOLLIENT

OZONIZED JOJOBA OILSKIN CONDITIONING - EMOLLIENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How OXIDIZED GLUTATHIONE appears in the CosIng inventory

The CosIng inventory lists OXIDIZED GLUTATHIONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

OXIDIZED GLUTATHIONE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

OXIDIZED GLUTATHIONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, OXIDIZED GLUTATHIONE carries the following function designation(s):

CAS 27025-41-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for OXIDIZED GLUTATHIONE

This page reproduces the CosIng inventory entry for OXIDIZED GLUTATHIONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research OXIDIZED GLUTATHIONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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