What does the restriction note for DIPHENHYDRAMINE HCL mean?

The restriction field for DIPHENHYDRAMINE HCL reads: II/339. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 147-24-0?

CAS 147-24-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains DIPHENHYDRAMINE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8506828/05/2020

DIPHENHYDRAMINE HCL

diphenhydramine hydrochloride

DIPHENHYDRAMINE HCL is linked to 1 EU annex record on this page. Inventory note: II/339.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 147-24-0

CAS 147-24-0PubChem CID 8980

Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride appears as white or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6. (NTP, 1992) — CAMEO Chemicals

IUPAC name: 2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride

Molecular formula: C17H22ClNO
Molecular weight: 291.8 g/mol
Exact mass: 291.1389920 Da
Topological polar surface area: 12.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 2
Defined stereocentres: 0

Also known as

Diphenhydramine HClAllergivalBendylateAntitussiveDenydrylDibenilEldadrylFenylhist

16 more reported names

HydramineSilphenBeldinBelixDiphenDiphenhydramine.HClFelbenBenaDimedrol hydrochlorideHalbmondVicks Formula 44WehydrylResminBenzhydramine hydrochlorideBanophenDifenhydramine hydrochloride

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1620
EPA DTXSID:DTXSID4020537
PubMed:16266919
PubMed:1679

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DIPHENHYDRAMINE HCL

INCI name

DIPHENHYDRAMINE HCL

Description

diphenhydramine hydrochloride

Record provenance

Inventory reference: 85068
Imported identity: DIPHENHYDRAMINE HCL
Source update: 28/05/2020

European Commission CosIng source notes

Annex records for DIPHENHYDRAMINE HCL

Annex II Restriction reference

Entry 339

Diphenhydramine (INN) and its salts

CAS: 58-73-1 / 147-24-0 / 88637-37-0

EC: 200-396-7 / 205-687-2 / 289-432-0

Key data

CAS

147-24-0

205-687-2

Restriction

II/339

Function

HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9196 · DIPHENHYDRAMINE HCl

Ingredients with overlapping formulation functions

DIPEPTIDE-1HAIR CONDITIONING, SKIN CONDITIONING

DIPEPTIDE-15HAIR CONDITIONING, SKIN CONDITIONING

DIPEPTIDE-20 HEXAPEPTIDE-40 OLIGOPEPTIDE-93 RH-POLYPEPTIDE-68 TETRAPEPTIDE-35ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

DIPEPTIDE-9HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

DIPHENYL AMODIMETHICONEHAIR CONDITIONING, HAIR FIXING

DIPHENYL DIMETHICONEANTIFOAMING, HAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMUL…

DIPHENYLISOPROPYL DIMETHICONEHAIR CONDITIONING, SKIN CONDITIONING

DIPHENYLSILOXY PHENYL TRIMETHICONEANTIFOAMING, HAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DIPHENHYDRAMINE HCL appears in the CosIng inventory

The CosIng inventory lists DIPHENHYDRAMINE HCL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DIPHENHYDRAMINE HCL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DIPHENHYDRAMINE HCL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for DIPHENHYDRAMINE HCL reads: "II/339". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, DIPHENHYDRAMINE HCL carries the following function designation(s):

CAS 147-24-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DIPHENHYDRAMINE HCL

This page combines the CosIng inventory entry for DIPHENHYDRAMINE HCL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research DIPHENHYDRAMINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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