Official EU label nameGlossary entry 9196
DIPHENHYDRAMINE HCl
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 3 of 13 indexed market datasets: 3 country records and 0 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
3
Evidence gaps
10
Resolved identifiers
6
Resolved substance identity
CAS:147-24-058-73-188637-37-0
EC:205-687-2200-396-7289-432-0
Ingredient index records:
DIPHENHYDRAMINE HCL
Cosmetic functions: HAIR CONDITIONING, SKIN CONDITIONING
diphenhydramine hydrochloride
Inventory restriction note: II/339
4 matched or reported names
DIPHENHYDRAMINE HCLDifenidramina* e seus saisDiphenhydramine (*) and its salts (CAS No. 58-73-1/147-24-0/88637-37-0)Diphenhydramine (INN) and its salts
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
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| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | No local match | 0 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review. |
| Great Britain GB | No local match | 0 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework. |
| Canada CA | No local match | 0 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | The Hotlist is an administrative compliance tool, not an exhaustive safety approval list. |
| New Zealand NZ | No local match | 0 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative. |
| ASEAN ASEAN | No local match | 0 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Regional annex coverage does not replace member-state implementation dates, notifications or national deviations. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | No local match | 0 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Korean source wording is canonical and other positive lists/notices may still apply to the formulation. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | Prohibited | 1Open record 1 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | Review every linked record and exact conditions. |
| India IN | Prohibited | 1Open record 1 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | Review every linked record and exact conditions. |
| Saudi Arabia SA | Prohibited | 1Open record 1 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | Review every linked record and exact conditions. |
No market rows match this filter.
Matching market records and conditions
India
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)Saudi Arabia
SFDA live prohibited/restricted lists, snapshot 30 August 2026Chemical identity and properties
CAS 147-24-0PubChem CID 8980
Diphenhydramine Hydrochloride
Diphenhydramine hydrochloride appears as white or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6. (NTP, 1992) — CAMEO Chemicals
- IUPAC name
- 2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
- Molecular formula
- C17H22ClNO
- Molecular weight
- 291.8 g/mol
- Exact mass
- 291.1389920 Da
- Topological polar surface area
- 12.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
Diphenhydramine HClAllergivalBendylateAntitussiveDenydrylDibenilEldadrylFenylhist
16 more reported names
HydramineSilphenBeldinBelixDiphenDiphenhydramine.HClFelbenBenaDimedrol hydrochlorideHalbmondVicks Formula 44WehydrylResminBenzhydramine hydrochlorideBanophenDifenhydramine hydrochloride
External database identifiers
- ChEMBL:CHEMBL1620
- EPA DTXSID:DTXSID4020537
- PubMed:16266919
- PubMed:1679
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 58-73-1PubChem CID 3100
Diphenhydramine
Diphenhydramine is an ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug. It has a role as a oneirogen, a sedative, a local anaesthetic, a H1-receptor antagonist, an antiparkinson drug, a muscarinic antagonist, an anti-allergic agent, an antiemetic, an antitussive, an antipruritic drug and an antidyskinesia agent. It is an ether and a tertiary amino compound. — ChEBI
- IUPAC name
- 2-benzhydryloxy-N,N-dimethylethanamine
- Molecular formula
- C17H21NO
- Molecular weight
- 255.35 g/mol
- Exact mass
- 255.162314293 Da
- XLogP3
- 3.3
- Topological polar surface area
- 12.5 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
BenzhydramineAlledrylProbedrylDihidralAntistominumBenzhydraminumBenzhydroaminaDiphantine
16 more reported names
BaramineDermodrinDesentolDibondrinHistaxinBenylanDifenhidraminaDifenidraminaRestaminRigidylDiphenylhydramineDiphenhydraminumEthanamine, 2-(diphenylmethoxy)-N,N-dimethyl-O-Benzhydryldimethylaminoethanol2-(Benzhydryloxy)-N,N-dimethylethylamineFAR 90X2
External database identifiers
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 88637-37-0PubChem CID 174697
Diphenhydramine Citrate
- IUPAC name
- 2-benzhydryloxy-N,N-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid
- Molecular formula
- C23H29NO8
- Molecular weight
- 447.5 g/mol
- Exact mass
- 447.18931688 Da
- Topological polar surface area
- 145.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 9
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
Diphenhydramine citrate [USP]4OD433S209Diphenhydramine citrate (USP)2-(Diphenylmethoxy)-N,N-dimethylethylamine citrate (1:1)(2-(Diphenylmethoxy)ethyl)dimethylammonium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylateRefChem:588810289-432-02-(Benzhydryloxy)-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate
16 more reported names
Diphenhydramine (citrate)Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)UNII-4OD433S209C23H29NO8Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1); Diphenhydramine citrateEINECS 289-432-02-(Benzhydryloxy)-N,N-dimethylethanamine2-hydroxypropane-1,2,3-tricarboxylateDIPHENHYDRAMINE CITRATE [MART.]DIPHENHYDRAMINE CITRATE [VANDF]2-benzhydryloxy-N,N-dimethylethanamine,2-hydroxypropane-1,2,3-tricarboxylic acidDIPHENHYDRAMINE CITRATE [USP-RS]DIPHENHYDRAMINE CITRATE [WHO-DD]DIPHENHYDRAMINE CITRATE [ORANGE BOOK]DIPHENHYDRAMINE CITRATE [USP MONOGRAPH]2-benzhydryloxy-N,N-dimethyl-ethanamine;citric acid2-Hydroxypropane-1,2,3-tricarboxylic acid--2-(diphenylmethoxy)-N,N-dimethylethan-1-amine (1/1)
External database identifiers
- ChEMBL:CHEMBL1201089
- EPA DTXSID:DTXSID80237211
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
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Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision