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InventoryRef 8455615/10/2010

DIISOPROPANOLAMINE

DIISOPROPANOLAMINE is linked to 1 EU annex record on this page. Inventory note: II/411.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Prohibited entry found
Open this evidence		1English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 110-97-4
CAS 110-97-4PubChem CID 8086

Diisopropanolamine

Diisopropanolamine appears as colorless liquid or white to yellow crystalline solid with an odor of dead fish or ammonia. Liquid floats and mixes with water. Solid sinks and mixes in water. (USCG, 1999) — CAMEO Chemicals

IUPAC name
1-(2-hydroxypropylamino)propan-2-ol
Molecular formula
C6H15NO2
Molecular weight
133.19 g/mol
Exact mass
133.110278721 Da
XLogP3
-0.8
Topological polar surface area
52.5 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Bis(2-hydroxypropyl)amineBis(2-propanol)amine1,1'-Iminodi-2-propanol2-Propanol, 1,1'-iminobis-Di-2-propanolaminedi-isopropanolamineDIPA (alcohol)Dipropyl-2,2'-dihydroxy-amine
16 more reported names
N,N-Bis(2-hydroxypropyl)amine1,1'-Iminobis-2-propanol2-Propanol, 1,1'-iminodi-NSC-49630W44HYL8T51,1'-Iminobis[2-propanol]CHEBI:1432661,1'-IMINOBIS(2-PROPANOL)203-820-9RefChem:5878481,1'-Iminodipropan-2-ol1-[(2-hydroxypropyl)amino]propan-2-ol1,1'-Azanediylbis(propan-2-ol)NSC 49632-Propanol,1,1'-iminobis-1,1'-azanediyldi(propan-2-ol)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8086

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1635) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H318 (51.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (48.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, P305+P354+P338, P317, and P337+P317 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1635 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 1635 reports by companies.; There are 6 notifications provided by 1634 of 1635 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P321, P337+P317, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Cosmetic Ingredient Review Conclusion: The Panel concludes that Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines are safe as cosmetic ingredients in the present practices of use and concentration. The isopropanolamines should not be used in products containing N-nitrosating agents. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated for diisopropanolamine(SRC), using a log Kow of -0.82(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC) from a log Kow of -0.82(2) and a regression derived equation(3) indicates that diisopropanolamine is expected to have very high mobility in soil(SRC). A pKa value of 9.1(4) indicates that the protonated form of diisopropanolamine will be the dominant species in moist soil surfaces and cations adsorb more strongly than neutral species. Batch adsorption experiments indicated that the adsorption mechanism of diisopropanolamine involves ionic interaction at cation exchange sites of soils and clays, and tends to be greatest in materials that have a large cation exchange capacity such as montmorillonite(5). Volatilization of diisopropanolamine from moist soil surfaces will not be an important fate process since cations do not volatilize. Diisopropanolamine is not expected to volatilize from dry soil surfaces(SRC) based upon its extrapolated vapor pressure of 1.25X10-4 mm Hg at 25 °C(6). Screening studies using sewage sludge indicated that diisopropanolamine does not biodegrade readily(4,7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC) from a log Kow of -0.82(2) and a regression derived equation(3) indicates that diisopropanolamine is not expected to adsorb to suspended solids and sediment in water(SRC). A pKa value of 9.1(4) indicates that the protonated form of diisopropanolamine will be the predominant species in water and cations adsorb more strongly to suspended solids and sediment than neutral species. Volatilization from water surfaces will not occur since cations do not volatilize(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Screening studies using sewage sludge indicated that diisopropanolamine does not biodegrade readily(4,7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diisopropanolamine, which has a vapor pressure of 1.25X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diisopropanolamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), from its rate constant of 1X10-10 cu cm/molecule-sec at 25 °C, that was derived using a structure estimation method(3). Diisopropanolamine is not expected to directly photolyze due to the lack of absorption in the environmental UV spectrum(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Hydraulic fluids; Absorbent; Brightener; Not Known or Reasonably Ascertainable; Intermediate; Solvent; Lubricating agent; pH regulating agent Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Diisopropanolamine Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as chemical intermediate, emulsifying agent (polishes, textile specialties, leather compounds, insecticides, cold wave permanent hair solutions, and water paints), antimicrobial agent in cutting fluids, and for removal of hydrogen sulfide and carbon dioxide from natural and industrial gases; Also used in adhesives, paper and paperboard, coatings, food packaging, and in prescription drugs; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Machining [Category: Heat or Machine]; Petroleum Production and Refining [Category: Industry]; Pulp and Paper Processing [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Farming (Pesticides) [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Chemical intermediate; agent for removal of hydrogen sulfide from natural gas Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Emulsifying agents for polishes, textile specialties, leather compounds, insecticides, cutting oils, and water paints Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Emulsifying and neutralizing agent in cosmetics. Removal of hydrogen sulfide and carbon dioxide from natural and industrial gases. Antimicrobial agent in cutting fluids. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The alkaline character of /diisopropanolamine/... is used to neutralize cosmetic preparations, such as cold wave solutions (hair perms), aerosol hair fixatives, and indoor tanning lotions. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Diisopropanolamine... /is/ used in adhesives, paper and paperboard, paper and paperboard coatings, and production aids and sanitizers for food packaging and, as such, are regulated as indirect food additives by the FDA... . ...Has been used in prescription drug formulations of theophylline and ophthalmic preparations of tropicamide. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DIISOPROPANOLAMINE

INCI name

DIISOPROPANOLAMINE

Record provenance

Inventory reference
84556
Imported identity
DIISOPROPANOLAMINE
Source update
15/10/2010
European Commission CosIng source notes

Key data

CAS
110-97-4
EC
203-820-9
Restriction
II/411
Function
BUFFERING
Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#8776 · DIISOPROPANOLAMINE

Ingredients with overlapping formulation functions

DIETHANOLAMINE BISULFATEBUFFERING
DIETHYL ETHANOLAMINEBUFFERING
DIETHYLAMINEBUFFERING, FRAGRANCE, PERFUMING
DIHYDROXYACETIC ACIDANTISTATIC, BUFFERING, HAIR WAVING OR STRAIGHTENING
DIISOPROPYLAMINEBUFFERING
DIMETHYL ISOPROPANOLAMINEBUFFERING
DIMETHYL MEABUFFERING
DIMETHYLGLUCAMINEBUFFERING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How DIISOPROPANOLAMINE appears in the CosIng inventory

The CosIng inventory lists DIISOPROPANOLAMINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DIISOPROPANOLAMINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DIISOPROPANOLAMINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for DIISOPROPANOLAMINE reads: "II/411". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, DIISOPROPANOLAMINE carries the following function designation(s):

CAS 110-97-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for DIISOPROPANOLAMINE

This page combines the CosIng inventory entry for DIISOPROPANOLAMINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research DIISOPROPANOLAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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