What does the restriction note for DIETHANOLAMINE BISULFATE mean?

The restriction field for DIETHANOLAMINE BISULFATE reads: II/411. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 59219-56-6?

CAS 59219-56-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains DIETHANOLAMINE BISULFATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3327415/10/2010

DIETHANOLAMINE BISULFATE

Bis(2-hydroxyethyl)ammonium hydrogen sulphate

DIETHANOLAMINE BISULFATE is linked to 1 EU annex record on this page. Inventory note: II/411.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 59219-56-6

CAS 59219-56-6PubChem CID 163199

Ethanol, 2,2'-iminobis-, sulfate (1:1)

The CIR Expert Panel concluded that diethanolamine and the 16 related salts listed below are safe in the present practices of use and concentration when formulated to be non-irritating. The Expert Panel cautions that ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed. — Cosmetic Ingredient Review (CIR)

IUPAC name: 2-(2-hydroxyethylamino)ethanol;sulfuric acid

Molecular formula: C4H13NO6S
Molecular weight: 203.22 g/mol
Exact mass: 203.04635831 Da
Topological polar surface area: 135.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 7
Covalent units: 2
Defined stereocentres: 0

Also known as

diethanolamine bisulfateEthanol, 2,2'-iminobis-, sulfate (1:1) (salt)R4254VF0K0RefChem:1084446261-663-1DIETHANOLAMINE SULFATE2,2'-Iminobis(ethanol) sulphatediethanolammonium sulfate

9 more reported names

UNII-R4254VF0K0EINECS 261-663-1EINECS 271-556-1Diethanolamine, hydrogen sulfate saltSDA 15-062-13BIS(2-HYDROXYETHYL)AMMONIUM HYDROGEN SULPHATEPMIUHGKUXIEDLL-UHFFFAOYSA-NDB-351178Sulfuric acid--2,2'-azanediyldi(ethan-1-ol) (1/1)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID50974646

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DIETHANOLAMINE BISULFATE

INCI name

DIETHANOLAMINE BISULFATE

Description

Bis(2-hydroxyethyl)ammonium hydrogen sulphate

Record provenance

Inventory reference: 33274
Imported identity: DIETHANOLAMINE BISULFATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for DIETHANOLAMINE BISULFATE

Annex II Restriction reference

Entry 411

Secondary alkyl- and alkanolamines and their salts

CAS: 111-42-2 / 110-97-4

EC: 203-868-0 / 203-820-9

Key data

CAS

59219-56-6

261-663-1

Restriction

II/411

Function

BUFFERING: Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#8553 · DIETHANOLAMINE BISULFATE

Ingredients with overlapping formulation functions

DIAMMONIUM CITRATEBUFFERING, CHELATING

DIAMMONIUM PHOSPHATEANTICORROSIVE, BUFFERING, ORAL CARE

DIBUTYL ETHANOLAMINEBUFFERING

DIETHANOLAMINEBUFFERING

DIETHYL ETHANOLAMINEBUFFERING

DIETHYLAMINEBUFFERING, FRAGRANCE, PERFUMING

DIHYDROXYACETIC ACIDANTISTATIC, BUFFERING, HAIR WAVING OR STRAIGHTENING

DIISOPROPANOLAMINEBUFFERING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DIETHANOLAMINE BISULFATE appears in the CosIng inventory

The CosIng inventory lists DIETHANOLAMINE BISULFATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DIETHANOLAMINE BISULFATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DIETHANOLAMINE BISULFATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for DIETHANOLAMINE BISULFATE reads: "II/411". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, DIETHANOLAMINE BISULFATE carries the following function designation(s):

BUFFERING

CAS 59219-56-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DIETHANOLAMINE BISULFATE

This page combines the CosIng inventory entry for DIETHANOLAMINE BISULFATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research DIETHANOLAMINE BISULFATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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