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CAS 51981-21-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8440015/10/2010

TETRASODIUM GLUTAMATE DIACETATE

L-Aspartic Acid, N, N-bis(zarboxylatomethyl )-L-glutamate; Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate

TETRASODIUM GLUTAMATE DIACETATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 51981-21-6

CAS 51981-21-6PubChem CID 44630158

Tetrasodium Glutamate Diacetate

IUPAC name: tetrasodium;(2S)-2-[bis(carboxylatomethyl)amino]pentanedioate

Molecular formula: C9H9NNa4O8
Molecular weight: 351.13 g/mol
Exact mass: 350.99189337 Da
Topological polar surface area: 164.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 9
Covalent units: 5
Defined stereocentres: 1

Also known as

UNII-5EHL50I4MY5EHL50I4MYTetrasodium N,N-Bis(carboxymethyl)-L-glutamateTetrasodium N,N-bis(carboxylatomethyl)-L-glutamateEINECS 257-573-7DISSOLVINE GLCHELEST CMG-40EC 257-573-7

16 more reported names

L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)L-Glutamic acid, N,N-bis(carboxymethyl)-, tetrasodium saltGLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALTN,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALTL-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALTRefChem:188887TETRASODIUM GLUTAMATE DIACETATE [INCI]N,N-Bis(carboxymethyl)-L-glutamic Acid Tetrasodium SaltN,N-bis-(Carboxymethyl)-L-glutamic Acid Tetrasodiumn Salt (40% in water)GLDAC9H9NNa4O8Sodium (S)-2-(bis(carboxylatomethyl)amino)pentanedioateN,N-BIS-(CARBOXYMETHYL)-L-GLUTAMIC ACID TETRASODIUMN SALTTETRASODIUM (2S)-2-[BIS(CARBOXYLATOMETHYL)AMINO]PENTANEDIOATEN,N-Bis(carboxymethyl)-L-glutamic acid tetrasodium salt (ca. 40% in Water)B2135

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External database identifiers

EPA DTXSID:DTXSID2052158

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TETRASODIUM GLUTAMATE DIACETATE

INCI name

TETRASODIUM GLUTAMATE DIACETATE

Description

L-Aspartic Acid, N, N-bis(zarboxylatomethyl )-L-glutamate; Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate

Record provenance

Inventory reference: 84400
Imported identity: TETRASODIUM GLUTAMATE DIACETATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TETRASODIUM GLUTAMATE DIACETATE

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Key data

CAS

51981-21-6

257-573-7

Restriction

—

Function

CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28690 · TETRASODIUM GLUTAMATE DIACETATE

Ingredients with overlapping formulation functions

TETRAPOTASSIUM PYROPHOSPHATEBUFFERING, CHELATING, ORAL CARE

TETRASODIUM DICARBOXYMETHYL ASPARTATECHELATING

TETRASODIUM EDTACHELATING

TETRASODIUM ETIDRONATECHELATING, EMULSION STABILISING, VISCOSITY CONTROLLING

TETRASODIUM HYDROXY IMINODISUCCINATECHELATING

TETRASODIUM IMINODISUCCINATECHELATING

TETRASODIUM PYROPHOSPHATEANTICAKING, BUFFERING, CHELATING, ORAL CARE

TEUPOLIOSIDEANTIOXIDANT, BLEACHING, CHELATING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TETRASODIUM GLUTAMATE DIACETATE appears in the CosIng inventory

The CosIng inventory lists TETRASODIUM GLUTAMATE DIACETATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TETRASODIUM GLUTAMATE DIACETATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TETRASODIUM GLUTAMATE DIACETATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TETRASODIUM GLUTAMATE DIACETATE carries the following function designation(s):

CHELATING

CAS 51981-21-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TETRASODIUM GLUTAMATE DIACETATE

This page reproduces the CosIng inventory entry for TETRASODIUM GLUTAMATE DIACETATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TETRASODIUM GLUTAMATE DIACETATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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