What does the restriction note for TETRASODIUM ETIDRONATE mean?

The restriction field for TETRASODIUM ETIDRONATE reads: III/53. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 3794-83-0?

CAS 3794-83-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TETRASODIUM ETIDRONATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3857015/10/2010

TETRASODIUM ETIDRONATE

Tetrasodium (1-hydroxyethylidene)bisphosphonate

TETRASODIUM ETIDRONATE is linked to 1 EU annex record on this page. Inventory note: III/53.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 3794-83-0

CAS 3794-83-0PubChem CID 19629

Tetrasodium Etidronate

IUPAC name: tetrasodium;1,1-diphosphonatoethanol

Molecular formula: C2H4Na4O7P2
Molecular weight: 293.96 g/mol
Exact mass: 293.90230359 Da
Topological polar surface area: 147.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 7
Covalent units: 5
Defined stereocentres: 0

Also known as

Tarpinel 4NLTurpinal 4NLSequion 10Na4etidronate tetrasodiumDefloc EN 43Dequest 2016UNII-CZZ9T1T1X4EINECS 223-267-7

16 more reported names

CZZ9T1T1X4Tetrasodium 1-hydroxyethylidene-1,1-diphosphonate(1-Hydroxyethylidene)diphosphonic acid, tetrasodium saltEthane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt1-Hydroxyethylidene-1,1-diphosphonic acid, tetrasodium saltTetrasodium 1-hydroxyethane-1, 1-diphosphonateEC 223-267-7ETIDRONATE TETRASODIUM [WHO-DD](1-Hydroxyethylidene)bisphosphonic acid, tetrasodium saltDIPHOSPHONIC ACID, (1-HYDROXYETHYLIDENE)-, TETRASODIUM SALTRefChem:188886TETRASODIUM ETIDRONATE [INCI]223-267-7(1-Hydroxyethylidene)bis-phosphonic acid tetrasodium saltPhosphonic acid, (1-hydroxyethylidene)bis-, tetrasodium salt(1-Hydroxyethylidene)bis-phosphonicacidtetrasodiumsalt

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID7029663

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TETRASODIUM ETIDRONATE

INCI name

TETRASODIUM ETIDRONATE

Description

Tetrasodium (1-hydroxyethylidene)bisphosphonate

Record provenance

Inventory reference: 38570
Imported identity: TETRASODIUM ETIDRONATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TETRASODIUM ETIDRONATE

Annex III Restriction reference

Entry 53

Etidronic acid

CAS: 2809-21-4

EC: 220-552-8

Key data

CAS

3794-83-0

223-267-7

Restriction

III/53

Function

CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
EMULSION STABILISING: Helping the process of emulsification and improving emulsion stability and shelf-life.
VISCOSITY CONTROLLING: Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28689 · TETRASODIUM ETIDRONATE

Ingredients with overlapping formulation functions

TETRAPOTASSIUM ETIDRONATECHELATING

TETRAPOTASSIUM PYROPHOSPHATEBUFFERING, CHELATING, ORAL CARE

TETRASODIUM DICARBOXYMETHYL ASPARTATECHELATING

TETRASODIUM EDTACHELATING

TETRASODIUM GLUTAMATE DIACETATECHELATING

TETRASODIUM HYDROXY IMINODISUCCINATECHELATING

TETRASODIUM IMINODISUCCINATECHELATING

TETRASODIUM PYROPHOSPHATEANTICAKING, BUFFERING, CHELATING, ORAL CARE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TETRASODIUM ETIDRONATE appears in the CosIng inventory

The CosIng inventory lists TETRASODIUM ETIDRONATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TETRASODIUM ETIDRONATE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TETRASODIUM ETIDRONATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for TETRASODIUM ETIDRONATE reads: "III/53". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, TETRASODIUM ETIDRONATE carries the following function designation(s):

CAS 3794-83-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TETRASODIUM ETIDRONATE

This page combines the CosIng inventory entry for TETRASODIUM ETIDRONATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research TETRASODIUM ETIDRONATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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