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InventoryRef 8379815/10/2010

ETHYL CAFFEATE

2-Propenoic Acid, 3-(3,4-Dihydroxyphenyl)-, Ethyl Ester

ETHYL CAFFEATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 102-37-4
CAS 102-37-4PubChem CID 5317238

Ethyl Caffeate

Ethyl trans-caffeate is an ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol. It has a role as an antineoplastic agent and an anti-inflammatory agent. It is an ethyl ester and an alkyl caffeate ester. It is functionally related to a trans-caffeic acid. — ChEBI

IUPAC name
ethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Molecular formula
C11H12O4
Molecular weight
208.21 g/mol
Exact mass
208.07355886 Da
XLogP3
2.6
Topological polar surface area
66.8 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

ethyl trans-caffeateEthyl 3,4-dihydroxycinnamateCaffeic acid ethyl ester76GBB1JU5YCHEBI:132714RefChem:596426108-430-1Ethyl 3-(3,4-dihydroxyphenyl)acrylate
16 more reported names
(E)-Ethyl Dihydroxycinnamate(E)-ethyl caffeate4gqqEthyl (2e)-3-(3,4-Dihydroxyphenyl)prop-2-Enoate(E)-ethyl 3-(3,4-dihydroxyphenyl)acrylateHY-N6966NSC-619661AC-34380ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, ethyl ester3-(3,4-Dihydroxy-phEthyl (E)-3-(3,4-dihydroxyphenyl)acrylateUNII-76GBB1JU5Y3,4-Dihydroxycinnamic acid ethyl ester3-(3,4-Dihydroxy-phenyl)-acrylic acid ethyl esterEthyl caffeate [M+H]+
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:132714

ethyl trans-caffeate

An ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol.

Formula
C11H12O4
Average mass
208.213 g/mol
Monoisotopic mass
208.07356 Da
Formal charge
0
  • alkyl caffeate ester — is a (CHEBI:65331)
  • ethyl ester — is a (CHEBI:23990)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • antineoplastic agent — has role (CHEBI:35610)
  • trans-caffeic acid — has functional parent (CHEBI:16433)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • antineoplastic agent — has role (CHEBI:35610)
  • alkyl caffeate ester — is a (CHEBI:65331)
  • ethyl ester — is a (CHEBI:23990)
Additional curated names
ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoateethyl (2E)-3-(3,4-dihydroxyphenyl)acrylateethyl 3,4-dihydroxycinnamateethyl caffeate(E)-ethyl 3-(3,4-dihydroxyphenyl)acrylate(E)-ethyl 3,4-dihydroxycinnamate(E)-ethyl caffeate
Cross-references from this source
  • CAS: 102-37-4 — ChemIDplus
  • REGISTRY_NUMBER: 2106401 — Reaxys
  • MANUAL_X_REF: 5317238 — PubChem Compound
  • MANUAL_X_REF: Ethyl_caffeate — Wikipedia

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2016-08-04. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match5317238

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (80%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 5 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ETHYL CAFFEATE

INCI name

ETHYL CAFFEATE

Description

2-Propenoic Acid, 3-(3,4-Dihydroxyphenyl)-, Ethyl Ester

Record provenance

Inventory reference
83798
Imported identity
ETHYL CAFFEATE
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
102-37-4
EC
—
Restriction
—
Function
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10035 · ETHYL CAFFEATE

Ingredients with overlapping formulation functions

ETHYL AZELAIC ACID/PROPANEDIOL COPOLYMERPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT, VISCOSITY CONTROLLING
ETHYL BALANITES ROXBURGHII SEEDATEHAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
ETHYL BIOTINATEHAIR CONDITIONING, SKIN CONDITIONING
ETHYL BUTYLACETYLAMINOPROPIONATESKIN CONDITIONING, SURFACTANT - CLEANSING
ETHYL CANNABIS SEEDATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
ETHYL CANOLATESKIN CONDITIONING
ETHYL CAPRATEPERFUMING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
ETHYL DECADIENOATESKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How ETHYL CAFFEATE appears in the CosIng inventory

The CosIng inventory lists ETHYL CAFFEATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ETHYL CAFFEATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ETHYL CAFFEATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ETHYL CAFFEATE carries the following function designation(s):

CAS 102-37-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for ETHYL CAFFEATE

This page reproduces the CosIng inventory entry for ETHYL CAFFEATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ETHYL CAFFEATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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