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InventoryRef 8379515/10/2010

PHENETHYL CAFFEATE

2-Propenoic Acid, 3-(3,4-Dihydroxyphenyl)-, 2-Phenylethyl Ester

PHENETHYL CAFFEATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 104594-70-9
CAS 104594-70-9CAS 115610-29-2PubChem CID 5281787

Caffeic Acid Phenethyl Ester

Caffeic Acid Phenethyl Ester is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, caffeic acid phenethyl ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1). — NCI Thesaurus (NCIt)

IUPAC name
2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Molecular formula
C17H16O4
Molecular weight
284.31 g/mol
Exact mass
284.10485899 Da
XLogP3
4.2
Topological polar surface area
66.8 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Phenethyl caffeateCAPECapeeeCHEBI:8062G960R9S5SK2-phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoateCAPE compoundRefChem:573319
16 more reported names
3-(3,4-Dihydroxyphenyl)-2-propenoic Acid, 2-Phenylethyl Estercaffeic acid phenyl esterphenethyl 3-(3,4-dihydroxyphenyl)acrylatePhenylethyl caffeatecaffeic acid phenylethyl ester(E)-phenethyl 3-(3,4-dihydroxyphenyl)acrylatePHENETHYL CAFFEATE (CAPE)2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester2-Phenylethyl (2e)-3-(3,4-Dihydroxyphenyl)prop-2-Enoate2-phenylethyl caffeateLopac0_000269HMS1791N22HMS3677D22LS-14562EU-0100269Phenethyl (E)-3-(3,4-Dihydroxyphenyl)acrylate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:8062

phenethyl caffeate

An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.

Formula
C17H16O4
Average mass
284.311 g/mol
Monoisotopic mass
284.10486 Da
Formal charge
0
  • alkyl caffeate ester — is a (CHEBI:65331)
  • immunomodulator — has role (CHEBI:50846)
  • antineoplastic agent — has role (CHEBI:35610)
  • metabolite — has role (CHEBI:25212)
  • antioxidant — has role (CHEBI:22586)
  • neuroprotective agent — has role (CHEBI:63726)
  • antiviral agent — has role (CHEBI:22587)
  • antibacterial agent — has role (CHEBI:33282)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • immunomodulator — has role (CHEBI:50846)
  • antineoplastic agent — has role (CHEBI:35610)
  • metabolite — has role (CHEBI:25212)
  • antioxidant — has role (CHEBI:22586)
  • neuroprotective agent — has role (CHEBI:63726)
  • antiviral agent — has role (CHEBI:22587)
  • antibacterial agent — has role (CHEBI:33282)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • alkyl caffeate ester — is a (CHEBI:65331)
Additional curated names
2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate2-phenylethyl caffeateCaffeic acid phenethyl esterCAPE
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-07-28. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match5281787

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (98.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 70 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PHENETHYL CAFFEATE

INCI name

PHENETHYL CAFFEATE

Description

2-Propenoic Acid, 3-(3,4-Dihydroxyphenyl)-, 2-Phenylethyl Ester

Record provenance

Inventory reference
83795
Imported identity
PHENETHYL CAFFEATE
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
104594-70-9 / 115610-29-2
EC
- / -
Restriction
—
Function
ANTIOXIDANT
Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20698 · PHENETHYL CAFFEATE

Records sharing a CAS or EC identity

ACETYL MANDELIC ACIDAMMONIUM MONOFLUOROPHOSPHATEATTAPULGITEBAICALINBETULA ALBA OILBUTETH-3 CARBOXYLIC ACIDCARAPA GUAIANENSIS SEED OILCARAPA GUAIANENSIS SEED POWDER

Ingredients with overlapping formulation functions

PHELLINUS BAUMII EXTRACTANTIOXIDANT, ASTRINGENT, HUMECTANT, SKIN CONDITIONING
PHELLINUS LINTEUS/INONOTUS OBLIQUUS EXTRACT FERMENT WATERANTIOXIDANT, HUMECTANT, SKIN CONDITIONING
PHELLINUS RIBIS EXTRACTANTIOXIDANT
PHELLODENDRON AMURENSE FRUIT EXTRACTANTIOXIDANT
PHENYL T-BUTYLNITRONEANTIOXIDANT
PHENYL THIAZINANE CARBOXYLIC ACIDANTIOXIDANT
PHENYLETHYL RESORCINOLANTIOXIDANT
PHENYLTHIOGLYCOLIC ACIDANTIOXIDANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How PHENETHYL CAFFEATE appears in the CosIng inventory

The CosIng inventory lists PHENETHYL CAFFEATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PHENETHYL CAFFEATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PHENETHYL CAFFEATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PHENETHYL CAFFEATE carries the following function designation(s):

CAS 104594-70-9 / 115610-29-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PHENETHYL CAFFEATE

This page reproduces the CosIng inventory entry for PHENETHYL CAFFEATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PHENETHYL CAFFEATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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