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InventoryRef 8677915/10/2010

BAICALIN

beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1- benzopyran-7-yl

BAICALIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 21967-41-9
CAS 21967-41-9PubChem CID 64982

Baicalin

Baicalin is the glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has a role as an antiatherosclerotic agent, an anticoronaviral agent, an EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor, a ferroptosis inhibitor, an antioxidant, an antibacterial agent, a non-steroidal anti-inflammatory drug, an antineoplastic agent, a prodrug, a neuroprotective agent, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a plant metabolite and a cardioprotective agent. It is a glucosiduronic acid, a dihydroxyflavone, a glycosyloxyflavone and a monosaccharide derivative. It is functionally related to a baicalein. It is a conjugate acid of a baicalin(1-). ChEBI

IUPAC name
(2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Molecular formula
C21H18O11
Molecular weight
446.4 g/mol
Exact mass
446.08491139 Da
XLogP3
1.1
Topological polar surface area
183.0 Ų
Hydrogen-bond donors
6
Hydrogen-bond acceptors
11
Covalent units
1
Defined stereocentres
5

Also known as

Baicalein 7-O-glucuronideBaicalein 7-glucuronide7-D-Glucuronic acid-5,6-dihydroxyflavone5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acidCHEBI:2981347Q89U4M55,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid7-D-glucuronic acid-5,6-dihydroxy-flavone
16 more reported names
beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-ylRefChem:5580633-784-35,6,7-trihydroxyflavone-7-O-beta-D-glucuronate(2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acidBaicalein 7-O-.beta.-D-glucuronideBaicalin 1000 microg/mL in Methanol5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide(2S,3S,4S,5R,6R)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid(2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid(2S,3S,4S,5R,6S)-6-[(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acidBaicaloside(2S,3S,4S,5R,6S)-6-[(4,6-dihydroxy-5-oxo-2-phenyl-5H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acidBaicalein-7-O-glucuronideBaicalin CRSBaicalin,(S)
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 314041-17-3
CAS 314041-17-3PubChem CID 24207712

5,6-dihydroxy-2-phenyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one;hydrate

IUPAC name
5,6-dihydroxy-2-phenyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one;hydrate
Molecular formula
C21H22O11
Molecular weight
450.4 g/mol
Exact mass
450.11621151 Da
Topological polar surface area
167.0 Ų
Hydrogen-bond donors
7
Hydrogen-bond acceptors
11
Covalent units
2
Defined stereocentres
5

Also known as

Baicalein 7-O-glucopyranoside monohydrate5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl beta-D-glucopyranoside--water (1/1)7-[(2S,4S,5S,3R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)(2H-3,4,5,6-tetrahydropy ran-2-yloxy)]-5,6-dihydroxy-2-phenylchromen-4-one, hydrate
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BAICALIN

INCI name

BAICALIN

Description

beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1- benzopyran-7-yl

Record provenance

Inventory reference
86779
Imported identity
BAICALIN
Source update
15/10/2010
European Commission CosIng source notes

Key data

CAS
21967-41-9 / 314041-17-3 (hydrate)
EC
- / -
Restriction
Function
ANTIOXIDANT
Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Records sharing a CAS or EC identity

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How BAICALIN appears in the CosIng inventory

The CosIng inventory lists BAICALIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BAICALIN is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BAICALIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BAICALIN carries the following function designation(s):

CAS 21967-41-9 / 314041-17-3 (hydrate) may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for BAICALIN

This page reproduces the CosIng inventory entry for BAICALIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BAICALIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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