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Official EU label nameGlossary entry 20698

PHENETHYL CAFFEATE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

Resolved substance identity

CAS:104594-70-9115610-29-2
Ingredient index records:
PHENETHYL CAFFEATE
Cosmetic functions: ANTIOXIDANT

2-Propenoic Acid, 3-(3,4-Dihydroxyphenyl)-, 2-Phenylethyl Ester

Open full local profile
1 matched or reported name
PHENETHYL CAFFEATE

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name PHENETHYL CAFFEATE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

Check the markets and their sourcesSearch every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 104594-70-9
CAS 104594-70-9CAS 115610-29-2PubChem CID 5281787

Caffeic Acid Phenethyl Ester

Caffeic Acid Phenethyl Ester is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, caffeic acid phenethyl ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1). — NCI Thesaurus (NCIt)

IUPAC name
2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Molecular formula
C17H16O4
Molecular weight
284.31 g/mol
Exact mass
284.10485899 Da
XLogP3
4.2
Topological polar surface area
66.8 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Phenethyl caffeateCAPECapeeeCHEBI:8062G960R9S5SK2-phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoateCAPE compoundRefChem:573319
16 more reported names
3-(3,4-Dihydroxyphenyl)-2-propenoic Acid, 2-Phenylethyl Estercaffeic acid phenyl esterphenethyl 3-(3,4-dihydroxyphenyl)acrylatePhenylethyl caffeatecaffeic acid phenylethyl ester(E)-phenethyl 3-(3,4-dihydroxyphenyl)acrylatePHENETHYL CAFFEATE (CAPE)2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester2-Phenylethyl (2e)-3-(3,4-Dihydroxyphenyl)prop-2-Enoate2-phenylethyl caffeateLopac0_000269HMS1791N22HMS3677D22LS-14562EU-0100269Phenethyl (E)-3-(3,4-Dihydroxyphenyl)acrylate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:8062

phenethyl caffeate

An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.

Formula
C17H16O4
Average mass
284.311 g/mol
Monoisotopic mass
284.10486 Da
Formal charge
0
  • alkyl caffeate ester — is a (CHEBI:65331)
  • immunomodulator — has role (CHEBI:50846)
  • antineoplastic agent — has role (CHEBI:35610)
  • metabolite — has role (CHEBI:25212)
  • antioxidant — has role (CHEBI:22586)
  • neuroprotective agent — has role (CHEBI:63726)
  • antiviral agent — has role (CHEBI:22587)
  • antibacterial agent — has role (CHEBI:33282)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • immunomodulator — has role (CHEBI:50846)
  • antineoplastic agent — has role (CHEBI:35610)
  • metabolite — has role (CHEBI:25212)
  • antioxidant — has role (CHEBI:22586)
  • neuroprotective agent — has role (CHEBI:63726)
  • antiviral agent — has role (CHEBI:22587)
  • antibacterial agent — has role (CHEBI:33282)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • alkyl caffeate ester — is a (CHEBI:65331)
Additional curated names
2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate2-phenylethyl caffeateCaffeic acid phenethyl esterCAPE
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-07-28. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match5281787

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (98.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 70 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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