Is BERGENIN safe to use in EU cosmetics?

BERGENIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 477-90-7?

CAS 477-90-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8364415/10/2010

BERGENIN

3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano(3,2-c)(2)benzopyran-6(H)-one

BERGENIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 477-90-7

CAS 477-90-7PubChem CID 66065

Bergenin

Bergenin is a natural product found in Cenostigma gardnerianum. It has a role as a metabolite. — ChEBI

IUPAC name: (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one

Molecular formula: C14H16O9
Molecular weight: 328.27 g/mol
Exact mass: 328.07943208 Da
XLogP3: -1.0
Topological polar surface area: 146.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 5

Also known as

YanbaicaisuBergeninumL84RBE4IDCNSC-661749NSC-7577964-Methoxy-2-(tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl)alpha-resorcylic acid gamma lactone(2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano(3,2-c)isochromen-6-one(-)-Bergenin

16 more reported names

RefChem:567029GlyTouCan:G67862GT803-760-9BengeninCuscutinBergenin [JAN]CorylopsinCHEBI:69499Bergenin (JAN)CCG-208553(2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-onePyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-C14H16O9B4349EN300-19651064(2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-2,3,4,4a-tetrahydropyrano[3,2-c]isochromen-6(10bH)-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:69499
ChEMBL:CHEMBL273019
EPA DTXSID:DTXSID4048141
PubMed:23054709
PubMed:22593249
PubMed:22574013
PubMed:22557239
PubMed:22437110
PubMed:22389182
PubMed:22275971
PubMed:22272145
PubMed:22253106
PubMed:22224047
PubMed:22206469
PubMed:22178680

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BERGENIN

INCI name

BERGENIN

INN name

Bergenin [JAN]

Description

3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano(3,2-c)(2)benzopyran-6(H)-one

Record provenance

Inventory reference: 83644
Imported identity: BERGENIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for BERGENIN

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Key data

CAS

477-90-7

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#3293 · BERGENIN

Ingredients with overlapping formulation functions

BERGENIA CILIATA ROOT EXTRACTSKIN CONDITIONING

BERGENIA CRASSIFOLIA LEAF EXTRACTHUMECTANT, SKIN CONDITIONING

BERGENIA EMEIENSIS ROOT EXTRACTSKIN CONDITIONING

BERGENIA LIGULATA ROOT EXTRACTSKIN CONDITIONING

BERTHOLLETIA EXCELSA FLOWER EXTRACTSKIN CONDITIONING

BERTHOLLETIA EXCELSA PERICARP EXTRACTSKIN CONDITIONING

BERTHOLLETIA EXCELSA SEED EXTRACTSKIN CONDITIONING

BERTHOLLETIA EXCELSA SEED OILSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BERGENIN appears in the CosIng inventory

The CosIng inventory lists BERGENIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BERGENIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BERGENIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BERGENIN carries the following function designation(s):

SKIN CONDITIONING

CAS 477-90-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BERGENIN

This page reproduces the CosIng inventory entry for BERGENIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BERGENIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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