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CAS 490-79-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8288115/10/2010

2,5-DIHYDROXYBENZOIC ACID

Gentisic acid; 5-Hydroxysalicylic Acid

2,5-DIHYDROXYBENZOIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 490-79-9

CAS 490-79-9PubChem CID 3469

2,5-Dihydroxybenzoic acid

2,5-dihydroxybenzoic acid is a dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions. It has a role as a MALDI matrix material, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, a mouse metabolite, a fungal metabolite and a human metabolite. It is functionally related to a benzoic acid. It is a conjugate acid of a 2,5-dihydroxybenzoate. — ChEBI

IUPAC name: 2,5-dihydroxybenzoic acid

Molecular formula: C7H6O4
Molecular weight: 154.12 g/mol
Exact mass: 154.02660867 Da
XLogP3: 1.6
Topological polar surface area: 77.8 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

gentisic acidBenzoic acid, 2,5-dihydroxy-5-Hydroxysalicylic acidHydroquinonecarboxylic acidGensigenGensigon2,5-Dhba2,5-Dioxybenzoic acid

16 more reported names

Salicylic acid, 5-hydroxy-Kyselina gentisinovaAcido gentisicoAcide gentisiqueAcidum gentisicumVP36V95O3TNSC-27224CHEBI:17189RefChem:639843207-718-5Gentisinic acidMesalazine EP Impurity GGentisic acid [INN]Gentisinate3,6-dihydroxybenzoic acidNSC 27224

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17189
ChEMBL:CHEMBL1461
EPA DTXSID:DTXSID4060078
PubMed:22976212
PubMed:22931516
PubMed:22930005
PubMed:22928018
PubMed:22915593
PubMed:22908568
PubMed:22877817
PubMed:22868116
PubMed:22838491
PubMed:22808015
PubMed:22803742
PubMed:22799495

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 2,5-DIHYDROXYBENZOIC ACID

INCI name

2,5-DIHYDROXYBENZOIC ACID

Description

Gentisic acid; 5-Hydroxysalicylic Acid

Record provenance

Inventory reference: 82881
Imported identity: 2,5-DIHYDROXYBENZOIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for 2,5-DIHYDROXYBENZOIC ACID

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Key data

CAS

490-79-9

207-718-5

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#166 · 2,5-DIHYDROXYBENZOIC ACID

Ingredients with overlapping formulation functions

10-HYDROXYSTEARIC ACIDSKIN CONDITIONING, SKIN PROTECTING

16-ALPHA ETHYL ESTRADIOLCARBOXYLATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

16-BETA METHYL ESTRADIOLPROPANOATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

2,3-BUTANEDIOLFRAGRANCE, HUMECTANT, SKIN CONDITIONING, SOLVENT

2,5-DIHYDROXYBENZOYL DIPEPTIDE-27HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

2,5-DIHYDROXYBENZOYL DIPEPTIDE-48HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

2-ACETYLHYDROQUINONEANTIOXIDANT, BLEACHING, SKIN CONDITIONING

2-AMINO-4,5-DIMETHYLTHIAZOLE HBRSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 2,5-DIHYDROXYBENZOIC ACID appears in the CosIng inventory

The CosIng inventory lists 2,5-DIHYDROXYBENZOIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

2,5-DIHYDROXYBENZOIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

2,5-DIHYDROXYBENZOIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 2,5-DIHYDROXYBENZOIC ACID carries the following function designation(s):

SKIN CONDITIONING

CAS 490-79-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 2,5-DIHYDROXYBENZOIC ACID

This page reproduces the CosIng inventory entry for 2,5-DIHYDROXYBENZOIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 2,5-DIHYDROXYBENZOIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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