Is ILOMASTAT safe to use in EU cosmetics?

ILOMASTAT is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 142880-36-2?

CAS 142880-36-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ILOMASTAT?

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InventoryRef 8234315/10/2010

ILOMASTAT

Butanediamide, N4-hydroxy-N1-((1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylpropyl)-, (2R)-

ILOMASTAT is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 142880-36-2

CAS 142880-36-2PubChem CID 132519

Ilomastat

Ilomastat is an N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor. It has a role as an antibacterial agent, an antineoplastic agent, a neuroprotective agent, an anti-inflammatory agent and an EC 3.4.24.24 (gelatinase A) inhibitor. It is a hydroxamic acid, a L-tryptophan derivative and a N-acyl-amino acid. — ChEBI

IUPAC name: (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide

Molecular formula: C20H28N4O4
Molecular weight: 388.5 g/mol
Exact mass: 388.21105539 Da
XLogP3: 0.9
Topological polar surface area: 123.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 2

Also known as

GalardinGM6001GM 6001CS 610GM-6001CS-610I0403ML141(R)-N(sup 1)-Hydroxy-N-((S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl)-2-isobutylsuccinamide

16 more reported names

(S-(R*,S*))-N(sup 4)-Hydroxy-N(sup 1)-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylopropyl)butanediamideCHEBI:137236ilomastatum(2R)-N'-hydroxy-N-((2S)-3-(1H-indol-3-yl)-1-methylamino-1-oxopropan-2-yl)-2-(2-methylpropyl)butanediamide(2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-methylamino-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamideRefChem:790596N'-hydroxy-N-((S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl)-2-isobutylsuccinamide(2R)-N'-hydroxy-N-((1S)-2-(1H-indol-3-yl)-1-(methylcarbamoyl)ethyl)-2-(2-methylpropyl)butanediamideButanediamide, N4-hydroxy-N1-((1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylpropyl)-,(2R)-Illomastat(R)-N1-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamideIlomastat (GM6001, Galardin)Ilomastat [USAN]3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDEGalardin MPI(2R)-2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:137236
ChEMBL:CHEMBL19611
EPA DTXSID:DTXSID0046353
PubMed:35687819
PubMed:34626302
PubMed:30549224
PubMed:26908177
PubMed:26490843
PubMed:24555532
PubMed:23894327
PubMed:23525277
PubMed:23462309
PubMed:23047022
PubMed:22581348
PubMed:22155090

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ILOMASTAT

INCI name

ILOMASTAT

INN name

Ilomastat [USAN]

Description

Butanediamide, N4-hydroxy-N1-((1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylpropyl)-, (2R)-

Record provenance

Inventory reference: 82343
Imported identity: ILOMASTAT
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ILOMASTAT

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Key data

CAS

142880-36-2

—

Restriction

—

Function

CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13505 · ILOMASTAT

Ingredients with overlapping formulation functions

GRAPHENEBULKING; CHELATING; COLORANT; UV ABSORBER

HALORUBRUM TEBENQUICHENSE LIPIDSANTIOXIDANT, CHELATING, FILM FORMING, HUMECTANT, SKIN CONDITIONING

HEDTAABSORBENT, BULKING, CHELATING, OPACIFYING, VISCOSITY CONTROLLING

HEXASODIUM BIS-(DIETHYLENE GLYCOL ETHYL) DIETHYLENETRIAMINE TRIMETHYLENE PHOSPH…CHELATING

KOJYL CARBOXY DIPEPTIDE-23ANTIOXIDANT, CHELATING, SKIN PROTECTING

KOJYL CARBOXY SH-NONAPEPTIDE-2ANTIOXIDANT, CHELATING, SKIN PROTECTING

LAUROYL ETHYLENEDIAMINE TRIACETIC ACIDCHELATING, SURFACTANT - CLEANSING

LYSINE AZELATEBLEACHING, CHELATING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ILOMASTAT appears in the CosIng inventory

The CosIng inventory lists ILOMASTAT as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ILOMASTAT is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ILOMASTAT is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ILOMASTAT carries the following function designation(s):

CAS 142880-36-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ILOMASTAT

This page reproduces the CosIng inventory entry for ILOMASTAT from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ILOMASTAT and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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