Is HEDTA safe to use in EU cosmetics?

HEDTA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does HEDTA serve in cosmetics?

According to the EU CosIng inventory, HEDTA carries the following function designation(s): ABSORBENT, BULKING, CHELATING, OPACIFYING, VISCOSITY CONTROLLING.

What other records share CAS 150-39-0?

CAS 150-39-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains HEDTA?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3423115/10/2010

HEDTA

N-(2-Hydroxyethyl)ethylenediaminetriacetic acid

HEDTA is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 150-39-0

CAS 150-39-0PubChem CID 8773

Hydroxyethylethylenediaminetriacetic acid

IUPAC name: 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid

Molecular formula: C10H18N2O7
Molecular weight: 278.26 g/mol
Exact mass: 278.11140092 Da
XLogP3: -6.2
Topological polar surface area: 139.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 0

Also known as

N-(2-Hydroxyethyl)ethylenediaminetriacetic acidHEDTAHeedtaVersenolVersenol 120(2-Hydroxyethyl)ethylenediaminetriacetic acid2-Hydroxyethylenediamine triacetateCaswell No. 487B

16 more reported names

N-(Hydroxyethyl)ethylenediaminetriacetic acidBRN 1804795HSDB 5651EINECS 205-759-3Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-(N-Hydroxyethylethylenedinitrilo)triacetic acidEPA Pesticide Chemical Code 039108UNII-R79J91U341NSC-7341n-Hydroxyethylethylenediamine-n,n',n'-triacetic acidHydroxyethyl ethylenediamine triacetic acidN-Hydroxyethylethylenedinitrilotriacetic acidN-(beta-Hydroxyethylethylenediamine)-N,N',N'-triacetic acidN-Hydroxy-N,N',N'-ethylenediaminetriacetic acid trisodium saltGlycine, N-(2-(bis(carboxymethyl)amino)ethyl)-N-(2-hydroxyethyl)-N-(2-(Bis(carboxymethyl)amino)ethyl)-N-(2-hydroxyethyl)glycine

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1620428
EPA DTXSID:DTXSID1059737
PubMed:22575537
PubMed:22536358
PubMed:22251571
PubMed:22140451
PubMed:21980395
PubMed:21880734
PubMed:21775425
PubMed:21598774
PubMed:21588859
PubMed:21547926
PubMed:21526224
PubMed:21224385

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HEDTA

INCI name

HEDTA

Description

N-(2-Hydroxyethyl)ethylenediaminetriacetic acid

Record provenance

Inventory reference: 34231
Imported identity: HEDTA
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for HEDTA

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Key data

CAS

150-39-0

205-759-3

Restriction

—

Function

ABSORBENT: Taking up water- and/or oil-soluble (dissolved or finely dispersed) substances.
BULKING: Non-reactive (chemically inert), solid ingredients that dilute other solids and/or increase the volume of cosmetic products.
CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
OPACIFYING: Reducing transparency or translucency of cosmetics.
VISCOSITY CONTROLLING: Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11651 · HEDTA

Ingredients with overlapping formulation functions

GOSSYPIUM HERBACEUM POWDERABSORBENT, OPACIFYING

HALLOYSITEABSORBENT, ANTI-SEBUM, COLORANT, VISCOSITY CONTROLLING

HDI/PEI-45/SMDI CROSSPOLYMERABSORBENT, PLASTICISER

HECTORITEABSORBENT, BULKING, VISCOSITY CONTROLLING

HELIANTHUS ANNUUS SEED FLOURABRASIVE, ABSORBENT, BULKING, VISCOSITY CONTROLLING

HELICHRYSUM ITALICUM LEAF CELL EXTRACTABSORBENT

HIMANTHALIA ELONGATA POWDERABSORBENT, BINDING, VISCOSITY CONTROLLING

HORDEUM VULGARE FLOURABSORBENT, BULKING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HEDTA appears in the CosIng inventory

The CosIng inventory lists HEDTA as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HEDTA is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HEDTA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HEDTA carries the following function designation(s):

CAS 150-39-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HEDTA

This page reproduces the CosIng inventory entry for HEDTA from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HEDTA and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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