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InventoryRef 8027915/10/2010

TOCOPHERYL SUCCINATE

.alpha.-Tocopheryl hydrogen succinate

TOCOPHERYL SUCCINATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 4345-03-3

CAS 4345-03-3PubChem CID 20353

alpha-Tocopherol succinate

Tocopherol succinate is a hemisuccinate and a tocol. — ChEBI

IUPAC name: 4-oxo-4-[[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid

Molecular formula: C33H54O5
Molecular weight: 530.8 g/mol
Exact mass: 530.39712482 Da
XLogP3: 10.2
Topological polar surface area: 72.8 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 3

Also known as

alpha-Tocopheryl succinate(+)-alpha-Tocopheryl succinated-alpha-Tocopherol acid succinateCovitol 1210alpha-Tocopheryl acid succinatealpha-Vitamin E succinateLU4B53JYVEalpha-Tocopherol, succinate

16 more reported names

alpha-Tocopherol hemisuccinate6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, hydrogen succinate, (+)-Succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester, (+)-4-oxo-4-(((2R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl)oxy)butanoic acidRefChem:555956vitamin e succinateD-alpha-Tocopherol succinatetocopherol succinateD-|A-Tocopherol succinateD-ALPHA-TOCOPHERYL SUCCINATEVitamin E hemisuccinate4-Oxo-4-(((R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl)oxy)butanoic acidAlpha-tocopherol succinate, d-a-Tocopheryl SuccinateVitamine E succinate.alpha.-Tocopherol succinate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:135821
ChEMBL:CHEMBL81421
EPA DTXSID:DTXSID2026151
PubMed:26981194
PubMed:22514541
PubMed:22427916
PubMed:22246736
PubMed:22240608
PubMed:22013885
PubMed:21880504
PubMed:21645609
PubMed:21296698
PubMed:20950962
PubMed:20926129
PubMed:20334518

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TOCOPHERYL SUCCINATE

INCI name

TOCOPHERYL SUCCINATE

Description

.alpha.-Tocopheryl hydrogen succinate

Record provenance

Inventory reference: 80279
Imported identity: TOCOPHERYL SUCCINATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TOCOPHERYL SUCCINATE

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Key data

CAS

4345-03-3 / 17407-37-3

224-403-8 / 241-433-7

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28946 · TOCOPHERYL SUCCINATE

Ingredients with overlapping formulation functions

TOCOPHERYL LINOLEATEANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

TOCOPHERYL LINOLEATE/OLEATEANTIOXIDANT, SKIN CONDITIONING

TOCOPHERYL NICOTINATEANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

TOCOPHERYL RETINOATEANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

TOCOPHERYL SUCCINATE METHYLGLUCAMIDEANTIOXIDANT, EMULSION STABILISING, SKIN CONDITIONING

TOCOPHERYLPHOSPHOCHOLINEANTIOXIDANT

TOCOQUINONEANTIOXIDANT, SKIN CONDITIONING

TOLUENEANTIOXIDANT, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TOCOPHERYL SUCCINATE appears in the CosIng inventory

The CosIng inventory lists TOCOPHERYL SUCCINATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TOCOPHERYL SUCCINATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TOCOPHERYL SUCCINATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TOCOPHERYL SUCCINATE carries the following function designation(s):

ANTIOXIDANT

CAS 4345-03-3 / 17407-37-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TOCOPHERYL SUCCINATE

This page reproduces the CosIng inventory entry for TOCOPHERYL SUCCINATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TOCOPHERYL SUCCINATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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