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InventoryRef 8027815/10/2010

TOCOPHERYL NICOTINATE

[2R-[2R*(4R*,8R*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate / [2R*(4R*,8R*)]-(.+-.)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl …

TOCOPHERYL NICOTINATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 16676-75-8

CAS 16676-75-8CAS 43119-47-7CAS 51898-34-1PubChem CID 27990

Tocopheryl Nicotinate

Tocopheryl nicotinate is a tocol. — ChEBI

IUPAC name: [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate

Molecular formula: C35H53NO3
Molecular weight: 535.8 g/mol
Exact mass: 535.40254455 Da
XLogP3: 11.4
Topological polar surface area: 48.4 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 3

Also known as

Vitamin E NicotinateRenascinVitamin E nicotinic acid esterWI1J5UCY5C[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] pyridine-3-carboxylate((2R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl) pyridine-3-carboxylateTocoferil nicotinateRefChem:898538

16 more reported names

tocopherol nicotinate(R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl nicotinateDL-alpha tocopheryl nicotinatedl-alpha-Tocopherol nicotinateDL-alpha-Tocopheryl Nicotinate( inverted exclamation markA)-|A-Tocopherol nicotinate(+/-)-alpha-Tocopherol nicotinateTocopherol nicotinate [JAN]D-alpha tocopheryl nicotinateQCP2FMP7I8C35H53NO33-Pyridinecarboxylic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester(2R-(2R*(4R*,8R*)))-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinaterel-(R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl nicotinaterel-(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl 3-pyridinecarboxylateJuvela nicotinate

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External database identifiers

ChEBI:CHEBI:32239
ChEMBL:CHEMBL1084541
EPA DTXSID:DTXSID1046396
EPA DTXSID:DTXSID401019802

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 86362-36-9

CAS 86362-36-9PubChem CID 5500

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate

IUPAC name: [2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate

Molecular formula: C35H53NO3
Molecular weight: 535.8 g/mol
Exact mass: 535.40254455 Da
XLogP3: 11.4
Topological polar surface area: 48.4 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

EINECS 289-227-6RefChem:486086289-227-6tocopherol nicotinateJuvela nicotinateC35H53NO3Hijuven3-Pyridinecarboxylic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, [2R-[2R*(4R*,8R*)]]-

4 more reported names

[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-yl] pyridine-3-carboxylate2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl pyridine-3-carboxylate[2R-2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol nicotinate2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl nicotinate #

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External database identifiers

EPA DTXSID:DTXSID40860600
PubMed:21051774
PubMed:12537931

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TOCOPHERYL NICOTINATE

INCI name

TOCOPHERYL NICOTINATE

Description

Record provenance

Inventory reference: 80278
Imported identity: TOCOPHERYL NICOTINATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TOCOPHERYL NICOTINATE

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Key data

CAS

16676-75-8 / 43119-47-7 / 51898-34-1 / 86362-36-9

256-101-7 / 257-501-4 / 289-227-6

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28943 · TOCOPHERYL NICOTINATE

Ingredients with overlapping formulation functions

TIMOSAPONIN A3SKIN CONDITIONING, SKIN PROTECTING

TISOCHRYSIS LUTEA OILANTIOXIDANT; COLORANT; SKIN PROTECTING

TOCOPHERYL GLYCERYL RETINOATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

TOCOPHERYL LINOLEATEANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

TOONA SINENSIS CALLUS EXTRACTANTIOXIDANT, SKIN PROTECTING

TORENIA CONCOLOR EXTRACTANTIOXIDANT, SKIN PROTECTING

TORILIS JAPONICA FRUIT EXTRACTSKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

TORULASPORA DELBRUECKII EXTRACTSKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TOCOPHERYL NICOTINATE appears in the CosIng inventory

The CosIng inventory lists TOCOPHERYL NICOTINATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TOCOPHERYL NICOTINATE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TOCOPHERYL NICOTINATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TOCOPHERYL NICOTINATE carries the following function designation(s):

CAS 16676-75-8 / 43119-47-7 / 51898-34-1 / 86362-36-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TOCOPHERYL NICOTINATE

This page reproduces the CosIng inventory entry for TOCOPHERYL NICOTINATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TOCOPHERYL NICOTINATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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