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InventoryRef 5977815/10/2010

TOCOPHERYL RETINOATE

Tocopheryl Retinoate is the ester of Tocopheryl (q.v.) and Retinoic Acid (q.v.)

TOCOPHERYL RETINOATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 40516-49-2
CAS 40516-49-2PubChem CID 5282180

(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl (+-)-retinoate

Tocoretinate is a tocol. ChEBI

IUPAC name
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
Molecular formula
C49H76O3
Molecular weight
713.1 g/mol
Exact mass
712.57944628 Da
XLogP3
16.9
Topological polar surface area
35.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
3

Also known as

Tocoretinatetretinoin tocoferilCTD060B1SSolcenonL-300N-021Tretinoine tocoferilTretinoina tocoferilo
16 more reported names
tretinoinum tocoferilumRefChem:9058263,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoateTocopheryl retinoated-alpha-Tocopheryl Retinoatedl-alpha-Tocopheryl RetinoateTretinoin tocoferil [INN]UNII-CTD060B1SSTretinoin tocoferil (JAN)0WN694NBMML300dl-?-Tocopheryl RetinoateTRETINOIN TOCOFERIL [JAN]Toco-retinoate(+-)-(2R*)-2,5,7,8-Tetramethyl-2-((4R*,8R*)-4,8,12-trimethyltridecyl)-6-chromanyl retinoateAC1NQZMB
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TOCOPHERYL RETINOATE

INCI name

TOCOPHERYL RETINOATE

Description

Tocopheryl Retinoate is the ester of Tocopheryl (q.v.) and Retinoic Acid (q.v.)

Record provenance

Inventory reference
59778
Imported identity
TOCOPHERYL RETINOATE
Source update
15/10/2010
European Commission CosIng source notes

Key data

EC
Restriction
Function
ANTIOXIDANT
Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
HUMECTANT
Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING
Maintaining the skin in good condition.
SKIN CONDITIONING - EMOLLIENT
Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How TOCOPHERYL RETINOATE appears in the CosIng inventory

The CosIng inventory lists TOCOPHERYL RETINOATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TOCOPHERYL RETINOATE is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TOCOPHERYL RETINOATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TOCOPHERYL RETINOATE carries the following function designation(s):

CAS 40516-49-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for TOCOPHERYL RETINOATE

This page reproduces the CosIng inventory entry for TOCOPHERYL RETINOATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TOCOPHERYL RETINOATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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