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InventoryRef 8027326/09/2017

TOCOPHEROL

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

TOCOPHEROL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 10191-41-0
CAS 10191-41-0PubChem CID 2116

DL-alpha-Tocopherol

2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol is a tocopherol. ChEBI

IUPAC name
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol
Molecular formula
C29H50O2
Molecular weight
430.7 g/mol
Exact mass
430.381080833 Da
XLogP3
10.7
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Ephanylalpha-Tocopherol, DL-Vitamin E DL-alphadl-.alpha.-TocopherolUNII-7QWA1RIO01DL-5,7,8-trimethyltocol7QWA1RIO01CCRIS 5853
16 more reported names
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-EINECS 233-466-0.Alpha.-tocopherol, DL-RONOTEC DF 120IRGANOX E 210UVINUL 2000AOBRN 0094012J24.789HINS NO.307CRAC-.ALPHA.-TOCOPHEROLINS-307CHSDB 8261EC 233-466-06-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-5-17-04-00168 (Beilstein Handbook Reference)DL-.ALPHA.-TOCOPHEROL [MI]
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:22470

α-tocopherol

A tocopherol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a 4,8,12-trimethyltridecyl group at position 2.

Formula
C29H50O2
Average mass
430.707 g/mol
Monoisotopic mass
430.38108 Da
Formal charge
0
  • tocopherol — is a (CHEBI:27013)
  • vitamin E — is a (CHEBI:33234)
  • plant metabolite — has role (CHEBI:76924)
  • food antioxidant — has role (CHEBI:77962)
  • plant metabolite — has role (CHEBI:76924)
  • food antioxidant — has role (CHEBI:77962)
  • tocopherol — is a (CHEBI:27013)
  • vitamin E — is a (CHEBI:33234)
Additional curated names
rel-(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol2,5,7,8-tetramethyl-2-(4',8',12'-trimethyltridecyl)-6-chromanol(+-)-alpha-tocopherolE 307E-307E307all-rac-alpha-tocopheroldl-alpha-tocopherol
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2023-05-31. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match2116

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 25.2% (567 of 2247) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (74.3%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2247 reports by companies from 11 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 567 of 2247 reports by companies.; There are 10 notifications provided by 1680 of 2247 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Toxicity Summary: IDENTIFICATION AND USE: dl-alpha-Tocopherol is a slightly viscous, pale yellow oil. This is a synthetic form of alpha tocopherol. The activity of natural alpha-tocopherol on an equal weight basis, is at least twice as high as the synthetic form. dl-alpha-Tocopherol is used as an antioxidant in fats and oils and in animal feed. It is also used as experimental medication and as a dietary supplement. HUMAN EXPOSURE AND TOXICITY: Of 23,908 patients patch tested, 219 (0.9%) had sunscreen coded as an allergen source. The top 3 most frequent allergens in sunscreens were benzophenone-3, dl-alpha-tocopherol, and fragrance mix. Dietary supplementation with moderate dosage synthetic dl-alpha-tocopherol acetate did not significantly prolong bleeding or platelet aggregation in healthy volunteers. dl-alpha-Tocopherol provided protection against exercise-induced oxidative injury in healthy volunteers according to several reports. In vitro experiments demonstrated general inhibition of cell proliferation by dl-alpha-tocopherol, with breast and prostate cancer cells distinctly more sensitive than erythroleukemia cells. ANIMAL STUDIES: In chicks exposed to dl-alpha-tocopherol acetate for 3-8 weeks i Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Although all forms of Vitamin E exhibit antioxidant activity, it is known that the antioxidant activity of vitamin E is not sufficient to explain the vitamin's biological activity. Vitamin E's anti-atherogenic activity involves the inhibition of the oxidation of LDL and the accumulation of oxLDL in the arterial wall. It also appears to reduce oxLDL-induced apoptosis in human endothelial cells. Oxidation of LDL is a key early step in atherogenesis as it triggers a number of events which lead to the formation of atherosclerotic plaque. In addition, vitamin E inhibits protein kinase C (PKC) activity. PKC plays a role in smooth muscle cell proliferation, and, thus, the inhibition of PKC results in inhibition of smooth muscle cell proliferation, which is involved in atherogenesis. Vitamin E's antithrombotic and anticoagulant activities involves the downregulation of the expression of intracellular cell adhesion molecule(ICAM)-1 and vascular cell adhesion molecule(VCAM)-1 which lowers the adhesion of blood components to the endothelium. In addition, vitamin E upregulates the expression of cytosolic phospholipase A2 and cyclooxygenase (COX)-1 which in turn enhances the release of prostacy Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 39 was calculated in fish for dl-alpha-tocopherol(SRC), using an estimated log Kow of 12.2(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not metabolized by the organism(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.5X10+7(SRC), determined from a structure estimation method(2), indicates that dl-alpha-tocopherol is expected to be immobile in soil(SRC). Volatilization of dl-alpha-tocopherol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.9X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(2). However, adsorption to soil is expected to attenuate volatilization(SRC). dl-alpha-Tocopherol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.4X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Naturally occurring alpha-tocopherol was biodegraded by aerobic bacterial communities isolated from marine sediment(3). However, biodegradation data on dl-alpha-tocopherol relevant to environmental importance in soil were not available.(SRC, 2015). dl-alpha-Tocopherol has a UV absorption maxima at 294 nm(4) and, therefore, may be susceptible to direct photolysis on soil surfaces exposed to sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.5X10+7(SRC), determined from a structure estimation method(2), indicates that dl-alpha-tocopherol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 7.9X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 29 hours and 15 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). The estimated volatilization half-life from a model pond is >10 years if adsorption is considered(4). According to a classification scheme(5), an estimated BCF of 39(SRC), from an estimated log Kow of 12.2(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Naturally occurring alpha-tocopherol was biodegraded by aerobic bacterial communities isolated from marine sediment(5). However, biodegr Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dl-alpha-tocopherol, which has an estimated vapor pressure of 1.4X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases (in the ambient atmosphere. Vapor-phase dl-alpha-tocopherol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.7 hours(SRC), calculated from its rate constant of 1.7X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase dl-alpha-tocopherol may be removed from the air by wet and dry deposition(SRC). dl-alpha-Tocopherol has a UV absorption maxima at 294 nm(3), and therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: The natural form of vitamin E found in green vegetables, grains, and oils; Used in antioxidants and as a vitamin E supplement; [Merck Index] Used as an antioxidant and nutritional additive in animals feeds; [ExPub: EFSA] Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Farming (Feed Additives) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
  • Uses: All-rac-alpha-tocopherol is mainly used as an antioxidant in fats and oils and in feedingstuffs rich in oils and fats. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: There are several forms of vitamin E available commercially /including dl-alpha-tocopherol/. These are available as nutritional supplements or in functional and fortified foods. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Laboratory chemicals; manufacture of substances Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 119-13-1
CAS 119-13-1PubChem CID 92094

Delta-Tocopherol

Delta-tocopherol is a tocopherol in which the chroman-6-ol core is substituted by a methyl group at position 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils. It has a role as a plant metabolite and a food antioxidant. It is a tocopherol and a vitamin E. ChEBI

IUPAC name
(2R)-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
Molecular formula
C27H46O2
Molecular weight
402.7 g/mol
Exact mass
402.349780706 Da
XLogP3
10.0
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
3

Also known as

(+)-delta-Tocopherol8-Methyltocol(2R)-3,4-dihydro-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol(R,R,R)-delta-TocopherolJU84X1II0N(2R,4'R,8'R)-delta-TocopherolJ5.309KCHEBI:47772
16 more reported names
(2R)-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol(2R)-3,4-DIHYDRO-2,8-DIMETHYL-2-((4R,8R)-4,8,12-TRIMETHYLTRIDECYL)-2H-1-BENZOPYRAN-6-OL(2R)-2,8-dimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-ol(2R)-2,8-dimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-olRefChem:131691RRR-DELTA-TOCOPHEROL(2R-(2R*(4R*,8R*)))-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol204-299-02,8-dimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-olD-delta-TOCOPHEROL.delta.-TocopherolE309(2R)-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-old-tocopheroldelta-Vitamin Edelta-D-Tocopherol
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match92094

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 99.3% (152 of 153) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 152 of 153 companies (only 0.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 153 reports by companies from 2 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 152 of 153 reports by companies.; There is 1 notification provided by 1 of 153 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1406-66-2
CAS 1406-66-2CAS 7616-22-0PubChem CID 14986

Tocopherols

Tocopherol is a class of vitamin E compounds naturally found in many different sources, such as oils, nuts, and vegetables. Tocopherols have antioxidant activity. NCI Thesaurus (NCIt)

IUPAC name
2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol
Molecular formula
C28H48O2
Molecular weight
416.7 g/mol
Exact mass
416.365430770 Da
XLogP3
10.3
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

MethyltocolsR0ZB2556P8LasarUnoVitVitaEVitamin EmpE VicotratMicorvit E
16 more reported names
E MulsinVitaPlus EVitamin E mpVitamin E-mpUno VitVitamin E DrageesDal EVitamin E, MowivitVitamin E, TogasanAntioxidans E-HevertVitamin E, VitaguttVitaminE EVIMIRALEVitamin E EVI MIRALEBatanaOilConju PrincessTocopherol 5%
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 16698-35-4
CAS 16698-35-4PubChem CID 6857447

Beta-Tocopherol

Beta-tocopherol is a tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 5 and 8. While it is found in low concentrations in many vegetable oils, only cottonseed oil contains significant amounts. It has a role as a plant metabolite and a food component. It is a tocopherol and a vitamin E. ChEBI

IUPAC name
(2R)-2,5,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
Molecular formula
C28H48O2
Molecular weight
416.7 g/mol
Exact mass
416.365430770 Da
XLogP3
10.3
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
3

Also known as

148-03-8d-beta-Tocopherol5,8-DimethyltocolCumotocopherolNeotocopherolp-Xylotocopherolbeta Tocopherol(2R)-2,5,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol
16 more reported names
CHEBI:477718K9365K9PXJ236.825K9U6A490501(2R)-2,5,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol(2R)-2,5,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-olRefChem:567985RRR-BETA-TOCOPHEROL3,4-Dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol2,5,8-trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol205-708-5240-747-1(R)-2,5,8-Trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol.beta.-Tocopherol2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-(rel)-|A-Tocopherol
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 2074-53-5
CAS 2074-53-5CAS 59-02-9PubChem CID 14985

alpha-Tocopherol

Alpha-Tocopherol is the orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. NCI Thesaurus (NCIt)

IUPAC name
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
Molecular formula
C29H50O2
Molecular weight
430.7 g/mol
Exact mass
430.381080833 Da
XLogP3
10.7
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
3

Also known as

59-02-9D-alpha-Tocopherol5,7,8-Trimethyltocol(+)-alpha-TocopherolPhytogermineEprolin(R,R,R)-alpha-Tocopherola-Vitamin E
16 more reported names
DenamoneViteolinEtavitEsorb(2R,4'R,8'R)-alpha-Tocopherolalpha Tocopherolalpha-Vitamin EAquasol Ealpha-Tocopherol, D-Vitamin-Ed-a-tocopherolTocopherol alphaDL-TocopherolViterra ED-alpha tocopherol(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 54-28-4
CAS 54-28-4PubChem CID 92729

(+)-gamma-Tocopherol

Gamma-tocopherol is a tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils. It has a role as a plant metabolite, a food antioxidant and an algal metabolite. It is a tocopherol and a vitamin E. ChEBI

IUPAC name
(2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
Molecular formula
C28H48O2
Molecular weight
416.7 g/mol
Exact mass
416.365430770 Da
XLogP3
10.3
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
3

Also known as

gamma-Tocopherol7,8-Dimethyltocolo-XylotocopherolGamma tocopherol8EF1Z1238FJ213.540JCHEBI:18185(2R)-3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
16 more reported names
(2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-olRRR-gamma-Tocopherol(R,R,R)-gamma-Tocopherol(2R)-3,4-DIHYDRO-2,7,8-TRIMETHYL-2-((4R,8R)-4,8,12-TRIMETHYLTRIDECYL)-2H-1-BENZOPYRAN-6-OL2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)-2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-(2R)-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-olRefChem:639607200-201-5231-523-42,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-olECY0XG64DOD-gamma-Tocopherol.gamma.-Tocopherol(r,r,r)-.gamma.-tocopherol
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TOCOPHEROL

INCI name

TOCOPHEROL

Description

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

Record provenance

Inventory reference
80273
Imported identity
TOCOPHEROL
Source update
26/09/2017
European Commission CosIng source notes

Key data

CAS
54-28-4 (gamma)/ 16698-35-4(beta) / 10191-41-0(DL) / 119-13-1 / 1406-18-4 / 1406-66-2 / 2074-53-5 (DL) / 59-02-9 (D)/7616-22-0
EC
200-201-5 / 240-747-1 / 233-466-0 / 204-299-0 /215-798-8 / - / 218-197-9 / 200-412-2 / -
Restriction
Function
ANTIOXIDANT
Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
FRAGRANCE
Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How TOCOPHEROL appears in the CosIng inventory

The CosIng inventory lists TOCOPHEROL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TOCOPHEROL is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TOCOPHEROL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TOCOPHEROL carries the following function designation(s):

CAS 54-28-4 (gamma)/ 16698-35-4(beta) / 10191-41-0(DL) / 119-13-1 / 1406-18-4 / 1406-66-2 / 2074-53-5 (DL) / 59-02-9 (D)/7616-22-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TOCOPHEROL

This page reproduces the CosIng inventory entry for TOCOPHEROL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TOCOPHEROL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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