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InventoryRef 7895515/10/2010

SIMETHICONE

Silica, hydrated, compounds with poly(dimethylsiloxane)

SIMETHICONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 8050-81-5
CAS 8050-81-5PubChem CID 6433516

Simethicone

Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed. Simethicone has been in use since the 1940s but was granted FDA approval in 1952. DrugBank

IUPAC name
dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
Molecular formula
C6H18O4Si3
Molecular weight
238.46 g/mol
Exact mass
238.05128865 Da
Topological polar surface area
52.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
2
Defined stereocentres
0

Also known as

Sentry SimethiconeMylanta Gas ReliefMylicon Infant's DropsSentry Simethicone EmulsionRefChem:8863423,3,5,5-tetramethyl-2,4-dioxa-3,5-disilahexane; silanedione617-098-1Simethicon
8 more reported names
Simethicone(200)Simethicone(500)SIMETICONEC6H18O4Si3Simethicone-Viscosity 500cPAMTWCFIAVKBGOD-UHFFFAOYSA-NDA-77848dioxosilane;methoxy-dimethyl-trimethylsilyloxy-silane
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SIMETHICONE

INCI name

SIMETHICONE

INN name

simethicone

Description

Silica, hydrated, compounds with poly(dimethylsiloxane)

Record provenance

Inventory reference
78955
Imported identity
SIMETHICONE
Source update
15/10/2010
European Commission CosIng source notes

Key data

EC
Restriction
Function
ANTIFOAMING
Suppressing foam during manufacturing or reducing the tendency of finished products to generate foam.
HAIR CONDITIONING
Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING
Maintaining the skin in good condition.
SKIN CONDITIONING - EMOLLIENT
Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How SIMETHICONE appears in the CosIng inventory

The CosIng inventory lists SIMETHICONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SIMETHICONE is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SIMETHICONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SIMETHICONE carries the following function designation(s):

CAS 8050-81-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for SIMETHICONE

This page reproduces the CosIng inventory entry for SIMETHICONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SIMETHICONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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