
Simethicone
Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed. Simethicone has been in use since the 1940s but was granted FDA approval in 1952. — DrugBank
- IUPAC name
- dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
- Molecular formula
- C6H18O4Si3
- Molecular weight
- 238.46 g/mol
- Exact mass
- 238.05128865 Da
- Topological polar surface area
- 52.6 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
8 more reported names
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.