Is COENZYME A safe to use in EU cosmetics?

COENZYME A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 85-61-0?

CAS 85-61-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 7546118/11/2016

COENZYME A

Adenosine 5'-(Trihydrogen Diphosphate), 3'-(Dihydrogen Phosphate), P'-(3-Hydroxy-4-((3-((2-Mercaptoethyl)Amino)-3-Oxopropyl)Amino)-2,2-Di methyl-4-Oxobutyl) Ester, (R)-

COENZYME A is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 85-61-0

CAS 85-61-0PubChem CID 87642

Coenzyme A

Coenzyme A is a thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. It has a role as a coenzyme, a mouse metabolite and an Escherichia coli metabolite. It is a secondary carboxamide, a member of 6-aminopurines, a nucleotide derivative and a thiol. It is functionally related to a 3'-phosphate-adenosine-5'-diphosphate. It is a conjugate acid of a coenzyme A(4-). — ChEBI

IUPAC name: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate

Molecular formula: C21H36N7O16P3S
Molecular weight: 767.5 g/mol
Exact mass: 767.11521025 Da
XLogP3: -5.8
Topological polar surface area: 348.0 Å²
Hydrogen-bond donors: 10
Hydrogen-bond acceptors: 21
Covalent units: 1
Defined stereocentres: 5

Also known as

CoASHCoA-SHZeelHSCoACOENZYME_ASAA04E81UX3'-phosphoadenosine-(5')diphospho(4')pantatheineCHEBI:15346

16 more reported names

3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] dihydrogen diphosphate}3'-phosphoadenosine 5'-(3-((3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-((3-oxo-3-((2-sulfanylethyl)amino)propyl)amino)butyl) dihydrogen diphosphate)RefChem:127396201-619-0CoAAluzimeDepot-ZeelCoenzyme ASHCoenzym Aco-enzyme-AHS-CoAReduced CoACo-A-SHC21H36N7O16P3SCoalipLucina

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:15346
ChEMBL:CHEMBL1213327
EPA DTXSID:DTXSID9048302
PubMed:28077572
PubMed:17371050
PubMed:16141203
PubMed:15155947
PubMed:14376210
PubMed:13052630
PubMed:12837950
PubMed:7989303
PubMed:2698229
PubMed:2384085
PubMed:7379

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for COENZYME A

INCI name

COENZYME A

Description

Adenosine 5'-(Trihydrogen Diphosphate), 3'-(Dihydrogen Phosphate), P'-(3-Hydroxy-4-((3-((2-Mercaptoethyl)Amino)-3-Oxopropyl)Amino)-2,2-Di methyl-4-Oxobutyl) Ester, (R)-

Record provenance

Inventory reference: 75461
Imported identity: COENZYME A
Source update: 18/11/2016

European Commission CosIng source notes

Annex records for COENZYME A

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Key data

CAS

85-61-0

201-619-0

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7232 · COENZYME A

Ingredients with overlapping formulation functions

CODONOPSIS LANCEOLATA ROOT EXTRACTSKIN CONDITIONING

CODONOPSIS TANGSHEN ROOT EXTRACTSKIN CONDITIONING

COELASTRELLA VACUOLATA OILSKIN CONDITIONING

COENOCHLORIS SIGNIENSIS EXTRACTSKIN CONDITIONING

COFFEA ARABICA FRUIT POWDERANTIOXIDANT, FLAVOURING, SKIN CONDITIONING

COFFEA ARABICA HUSK EXTRACTANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

COFFEA ARABICA LEAF EXTRACTSKIN CONDITIONING

COFFEA ARABICA LEAF/SEED EXTRACTFRAGRANCE, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How COENZYME A appears in the CosIng inventory

The CosIng inventory lists COENZYME A as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

COENZYME A is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

COENZYME A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, COENZYME A carries the following function designation(s):

SKIN CONDITIONING

CAS 85-61-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for COENZYME A

This page reproduces the CosIng inventory entry for COENZYME A from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research COENZYME A and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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