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InventoryRef 7477015/10/2010

BUTYRIC ACID

Butanoic acid

BUTYRIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 107-92-6
CAS 107-92-6PubChem CID 264

Butyric Acid

Butyric acid is a straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group. It has a role as a Mycoplasma genitalium metabolite and a human urinary metabolite. It is a fatty acid 4:0 and a straight-chain saturated fatty acid. It is a conjugate acid of a butyrate. — ChEBI

IUPAC name
butanoic acid
Molecular formula
C4H8O2
Molecular weight
88.11 g/mol
Exact mass
88.052429494 Da
XLogP3
0.8
Topological polar surface area
37.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

n-Butyric acidn-Butanoic acidpropylformic acidethylacetic acid1-propanecarboxylic acidButanic acid1-Butyric acidButtersaeure
16 more reported names
Kyselina maselnaFEMA No. 2221Propanecarboxylic acid1-butanoic acidFEMA Number 2221Butyricum acidumNORMAL BUTYRIC ACIDNSC-841540UIR9Q29HNSC8415CHEBI:30772Acid, ButanoicTetranoic AcidAcid, ButyricButyrate, Magnesiumfatty acid 4:0
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:30772

butyric acid

A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Formula
C4H8O2
Average mass
88.106 g/mol
Monoisotopic mass
88.05243 Da
Formal charge
0
  • straight-chain saturated fatty acid — is a (CHEBI:39418)
  • fatty acid 4:0 — is a (CHEBI:140601)
  • Mycoplasma genitalium metabolite — has role (CHEBI:131604)
  • human urinary metabolite — has role (CHEBI:84087)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • Mycoplasma genitalium metabolite — has role (CHEBI:131604)
  • human urinary metabolite — has role (CHEBI:84087)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • straight-chain saturated fatty acid — is a (CHEBI:39418)
  • fatty acid 4:0 — is a (CHEBI:140601)
  • butyrate — is conjugate acid of (CHEBI:17968)
Additional curated names
butanoic acid1-butanoic acid1-butyric acid1-propanecarboxylic acid4:0acide butanoiqueacide butyriquebutanic acidButanoateButanoic acidBUTANOIC ACIDbutoic acidButtersaeurebutyric acidButyric acidButyricum acidumC4:0CH3-[CH2]2-COOHn-butanoic acidn-butyric acidethylacetic acidFEMA NO. 2221Normal butyric acidNSC-8415propanecarboxylic acidpropylformic acid
Cross-references from this source
  • CAS: 107-92-6 — ChemIDplus
  • CAS: 107-92-6 — NIST Chemistry WebBook
  • CAS: 107-92-6 — KEGG COMPOUND
  • REGISTRY_NUMBER: 26242 — Gmelin
  • REGISTRY_NUMBER: 906770 — Reaxys
  • MANUAL_X_REF: BUA — PDBeChem
  • MANUAL_X_REF: Butyric_acid — Wikipedia
  • MANUAL_X_REF: BUTYRIC_ACID — MetaCyc
  • MANUAL_X_REF: C00001180 — KNApSAcK
  • MANUAL_X_REF: C00246 — KEGG COMPOUND
  • MANUAL_X_REF: DB03568 — DrugBank
  • MANUAL_X_REF: HMDB0000039 — HMDB
  • MANUAL_X_REF: LMFA01010004 — LIPID MAPS

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-01-23. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match264

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • ERG2024, Guide 153 (Butyric acid): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (15.5%): Harmful if swallowed [Warning Acute toxicity, oral]; H314 (99%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (14.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2131 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P260, P262, P264, P264+P265, P270, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P321, P361+P364, P363, P370+P378, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Health Effects: Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When this occurs symptoms such as muscle weakness, fatigue, muscle cramps, fasciculation, and paralysis can be seen. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system. Symptoms associated with this are hypertension, and hypoglycemia. Overstimulation of nicotinic acetylcholine receptors in the central nervous system, due to accumulation of ACh, results in anxiety, headache, convulsions, ataxia, depression of respiration and circulation, tremor, general weakness, and potentially coma. When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, incre Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Butyric acid is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase. Because of its essential function, chemicals that interfere with the action of acetylcholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death. Nerve gases and many substances used in insecticides have been shown to act by binding a serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a h Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 3.2 was calculated for n-butanoic acid(SRC), using a log Kow of 0.79(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 64(SRC), determined from a log Kow of 0.79(2) and a regression-derived equation(3), and experimental values of 19.1, 27.6, and 14.7 in mud, muddy sand, and sand(4), indicate that n-butanoic acid is expected to have very high to high mobility in soil(SRC). The pKa of n-butanoic acid is 4.82(5), indicating that this compound will primarily exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). Volatilization of butyric acid from moist soil surfaces is expected to be slow(SRC) given a Henry's Law constant of 5.35X10-7 atm-cu m/mole(7). n-Butanoic acid is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.65 mm Hg(8). N-butanoic acid may be susceptible to biodegradation in terrestrial environments based on the observed degradation of 72% after 5 hours when incubated with activated sludge(9,10). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), experimental Koc values of 19.1, 27.6, and 14.7 on a clastic mud (3.5% organic carbon), a lateritic muddy sand (1.3% organic carbon), and a fine carbonate sand (0.17% organic carbon), respectively(2), indicate that n-butanoic acid is not expected to adsorb to suspended solids and sediment(SRC). The pKa of n-butanoic acid is 4.82(5), indicating that this compound will primarily exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). Volatilization from water surfaces is expected to be slow(3) based upon a Henry's Law constant of 5.35X10-7 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 64 and 471 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 3.2(SRC), from a log Kow of 0.79(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is low(SRC). n-Butanoic acid may be susceptible to biodegradation in aquatic environments based on the observed Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-butanoic acid, which has a vapor pressure of 1.65 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase butyric acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 days(SRC), calculated from its rate constant of 2.40X10-12 cu cm/molecule-sec at 25 °C(3). n-Butanoic acid does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(4). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BUTYRIC ACID

INCI name

BUTYRIC ACID

Description

Butanoic acid

Record provenance

Inventory reference
74770
Imported identity
BUTYRIC ACID
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
107-92-6
EC
203-532-3
Restriction
—
Function
FRAGRANCE
Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#4210 · BUTYRIC ACID

Ingredients with overlapping formulation functions

BUTYL STEARATEFRAGRANCE, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
BUTYLENE GLYCOLFRAGRANCE, HUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING
BUTYLPARABENFRAGRANCE, PRESERVATIVE
BUTYLPHENYL METHYLPROPIONALFRAGRANCE, PERFUMING
BUTYROLACTONEFRAGRANCE, SOLVENT
C30-34 ALKANEEMULSION STABILISING; FRAGRANCE; VISCOSITY CONTROLLING; SKIN CONDITIONING - MISCELLANEOUS
CAFFEIC ACIDANTIOXIDANT, FRAGRANCE
CALCIUM ACETATEFRAGRANCE, VISCOSITY CONTROLLING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How BUTYRIC ACID appears in the CosIng inventory

The CosIng inventory lists BUTYRIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BUTYRIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BUTYRIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BUTYRIC ACID carries the following function designation(s):

CAS 107-92-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for BUTYRIC ACID

This page reproduces the CosIng inventory entry for BUTYRIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BUTYRIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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