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InventoryRef 7475610/10/2019

BUTYLENE GLYCOL

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

BUTYLENE GLYCOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 107-88-0
CAS 107-88-0PubChem CID 7896

1,3-Butanediol

Butane-1,3-diol is a butanediol compound having two hydroxy groups in the 1- and 3-positions. It is a glycol and a butanediol. — ChEBI

IUPAC name
butane-1,3-diol
Molecular formula
C4H10O2
Molecular weight
90.12 g/mol
Exact mass
90.068079557 Da
XLogP3
-0.4
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

1,3-Butylene glycolButylene glycol1,3-Dihydroxybutanebeta-Butylene glycolMethyltrimethylene glycol1-Methyl-1,3-propanediol1,3 Butylene glycol1,3-Butandiol
16 more reported names
(RS)-1,3-Butandiol1,3-ButylenglykolCaswell No. 128GGNSC-4021453XUS85K0RABRN 1731276AI3-11077CHEBI:52683Herbal MoxibustionChinese medicine patchMUMMY MASKRefChem:545843% Hyaluronic Acid SerumNatural Oriental Herb CareSrripo Biotin Hair Treatmentacmeros Lubricant X0026F3541
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:52683

butane-1,3-diol

A butanediol compound having two hydroxy groups in the 1- and 3-positions.

Formula
C4H10O2
Average mass
90.122 g/mol
Monoisotopic mass
90.06808 Da
Formal charge
0
  • glycol — is a (CHEBI:13643)
  • butanediol — is a (CHEBI:52684)
  • glycol — is a (CHEBI:13643)
  • butanediol — is a (CHEBI:52684)
Additional curated names
butane-1,3-diol1,3-Butandiol1,3-Butanediol1,3 Butylene glycol1,3-Butylene glycol1,3-Butylenglykol1,3-Dihydroxybutane1-Methyl-1,3-propanediolbeta-Butylene glycolButane-1,3-diolMethyltrimethylene glycol(RS)-1,3-Butandiol
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2022-01-17. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7896

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 46.2% (1160 of 2513) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (51.2%): Flammable liquid and vapor [Warning Flammable liquids] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2513 reports by companies from 8 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 1160 of 2513 reports by companies.; There are 6 notifications provided by 1353 of 2513 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: 1,3-Butanediol is an odorless, colorless, viscous liquid with a sweet flavor and bitter aftertaste. It is used as an intermediate in manufacture of polyester plasticizers; humectant for cellophane, tobacco; and in the cosmetic and pharmaceutical industry as a glycerin substitute.1,3-Butanediol also has some mold inhibiting action. It is not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: 1,3-Butanediol is not irritating to human skin or mucous membranes. When applied to the human eye it causes immediate severe stinging, but irrigation with water brings rapid complete relief. ANIMAL STUDIES: Eye irritation occurred in one individual, although its irritant potency in rabbits appeared low. It was of low acute oral toxicity to rodents. No treatment-related effects on mortality, body weight gain, organ weights, hematology, histopathology or neoplastic changes were observed in rats fed 1,3-butanediol in the diet at 1, 3 or 10% (~ 643, 1960 or 6230 mg/kg-bw/day for males or ~ 844, 2330 or 7300 Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 1,3-butanediol(SRC), using an estimated log Kow of -0.29(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1,3-butanediol is expected to have very high mobility in soil(SRC). Volatilization of 1,3-butanediol from moist soil surfaces is not expected(SRC) given an estimated Henry's Law constant of 2.4X10-9 atm-cu m/mole(SRC), based upon its vapor pressure, 0.02 mm Hg(3), and assigned value for water solubility, 1X10+6 mg/L (miscible)(4). 1,3-Butanediol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). 1,3-Butanediol is expected to be readily biodegraded based on modified Sturm test results of 80.5% in 28 days(5). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1,3-butanediol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.4X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 0.02 mm Hg(4), and assigned value for water solubility, 1X10+6 mg/L (miscible)(5). 1,3-Butanediol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of -0.29(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 1,3-Butanediol is expected to be readily biodegraded based on modified Sturm test results of 80.5% in 28 days(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,3-butanediol, which has a vapor pressure of 0.02 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,3-butanediol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 hours(SRC), calculated from its rate constant of 3.32X10-11 cu cm/molecule-sec at 25 °C(3). 1,3-Butanediol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Link: CIR ingredient: Butylene Glycol Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as an intermediate in the manufacture of polyester plasticizers; as a humectant for cellophane and tobacco; in polyurethanes and special polyester resins; in surface active agents; as a coupling agent; as a solvent; as a food additive and flavoring; in the cosmetics and pharmaceutical industries as a glycerin substitute; for deicing of aircraft; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For 1,3-butanediol (USEPA/OPP Pesticide Code: 042205) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The active ingredient is no longer contained in any registered pesticide products ... "cancelled." Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Intermediate in manufacture of polyester plasticizers; humectant for cellophane, tobacco. Has some mold inhibiting action. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Polyesters, polyurethanes, surface active agents; plasticizers, humectant, coupling agent, solvent, food additive, flavoring. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 1,3-BUTANEDIOL (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,3-Butanediol is found in pepper (c. annuum). It is commonly used as a solvent for food flavouring agents and is a co-monomer used in certain polyurethane and polyester resins. In biology, 1,3-butanediol is used as a hypoglycaemic agent. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6290-03-5
CAS 6290-03-5PubChem CID 637497

(-)-1,3-Butanediol

(R)-butane-1,3-diol is a butane-1,3-diol of R-configuration. It is an enantiomer of a (S)-butane-1,3-diol. — ChEBI

IUPAC name
(3R)-butane-1,3-diol
Molecular formula
C4H10O2
Molecular weight
90.12 g/mol
Exact mass
90.068079557 Da
XLogP3
-0.4
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
1

Also known as

1,3-Butanediol, (3R)-RefChem:407056(R)-butane-1,3-diol(R)-(-)-1,3-Butanediol(R)-1,3-butanediol(R)-(-)-Butane-1,3-diol(R)-(-)-1,3-Butylene Glycol(R)-(-)-1,3-Dihydroxybutane
16 more reported names
1,3-Butanediol, (R)-CHEBI:52687(R)-(-)-1,3-Butanediol, 98%AS-11116HY-77490B1159EN300-7206273(R)?-?(-?)?-?1,?3-?ButanediolBU41,3-Butanediol #1,3-(R)-butanedio1,3-(R)-butanediol(R)-(-)-1,3-butandiolCS-M1638EINECS 228-532-0AC-5640
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BUTYLENE GLYCOL

INCI name

BUTYLENE GLYCOL

Description

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7)
(R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Record provenance

Inventory reference
74756
Imported identity
BUTYLENE GLYCOL
Source update
10/10/2019
European Commission CosIng source notes
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Key data

CAS
107-88-0 (i), 6290-03-5 (ii)
EC
203-529-7 (i), 228-532-0 (ii)
Restriction
—
Function
FRAGRANCE
Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
HUMECTANT
Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING
Maintaining the skin in good condition.
SOLVENT
Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).
VISCOSITY CONTROLLING
Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#4173 · BUTYLENE GLYCOL

Ingredients with overlapping formulation functions

BUTYL HYDROXYBUTYRATESOLVENT
BUTYL LACTATEFRAGRANCE, SOLVENT
BUTYL LEVULINATESKIN CONDITIONING - EMOLLIENT; SOLVENT
BUTYL PG-ACETAL LEVULINATESKIN CONDITIONING - EMOLLIENT; SOLVENT
BUTYLENE GLYCOL PROPIONATESOLVENT
BUTYLOCTANOLHUMECTANT, SOLVENT
BUTYLOCTYL BENZOATEPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT
BUTYLOCTYL SALICYLATEHAIR CONDITIONING, SKIN CONDITIONING, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How BUTYLENE GLYCOL appears in the CosIng inventory

The CosIng inventory lists BUTYLENE GLYCOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BUTYLENE GLYCOL is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BUTYLENE GLYCOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BUTYLENE GLYCOL carries the following function designation(s):

CAS 107-88-0 (i), 6290-03-5 (ii) may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BUTYLENE GLYCOL

This page reproduces the CosIng inventory entry for BUTYLENE GLYCOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BUTYLENE GLYCOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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