Is BUTYROLACTONE safe to use in EU cosmetics?

BUTYROLACTONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 96-48-0?

CAS 96-48-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains BUTYROLACTONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 7477215/10/2010

BUTYROLACTONE

.gamma.-Butyrolactone

BUTYROLACTONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 96-48-0

CAS 96-48-0PubChem CID 7302

Gamma-Butyrolactone

4-butyrolactone is a clear colorless oily liquid with a pleasant odor. (NTP, 1992) — CAMEO Chemicals

IUPAC name: oxolan-2-one

Molecular formula: C4H6O2
Molecular weight: 86.09 g/mol
Exact mass: 86.036779430 Da
XLogP3: -0.6
Topological polar surface area: 26.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

BUTYROLACTONEdihydrofuran-2(3H)-one4-Butyrolactone4-Butanolide1,4-Butanolide4-Hydroxybutyric acid lactone2-OxolanoneDihydro-2(3H)-furanone

16 more reported names

Butyryl lactoneButyrylactone4-Deoxytetronic acid1,2-ButanolideButyric acid lactoneBLONgamma-BL2(3H)-Furanone, dihydro-Tetrahydro-2-furanone4-Hydroxybutanoic acid lactonegamma-Hydroxybutyric acid lactoneDihydro-2-furanone1,4-LactoneAgrisynth BLOgamma-64802-Oxotetrahydrofuran

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:42639
ChEMBL:CHEMBL95681
EPA DTXSID:DTXSID6020224
PubMed:33358762
PubMed:23124567
PubMed:23084934
PubMed:23074886
PubMed:23010454
PubMed:22980827
PubMed:22897371
PubMed:22839725
PubMed:22803370
PubMed:22792788
PubMed:22761035
PubMed:22748707

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BUTYROLACTONE

INCI name

BUTYROLACTONE

Description

.gamma.-Butyrolactone

Record provenance

Inventory reference: 74772
Imported identity: BUTYROLACTONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for BUTYROLACTONE

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Key data

CAS

96-48-0

202-509-5

Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
SOLVENT: Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#4212 · BUTYROLACTONE

Ingredients with overlapping formulation functions

BUTYLENE GLYCOL PROPIONATESOLVENT

BUTYLOCTANOLHUMECTANT, SOLVENT

BUTYLOCTYL BENZOATEPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

BUTYLOCTYL SALICYLATEHAIR CONDITIONING, SKIN CONDITIONING, SOLVENT

C10-11 AROMATIC HYDROCARBONSSOLVENT

C10-11 ISOALKANESOLVENT; VISCOSITY CONTROLLING

C10-11 ISOPARAFFINSOLVENT, VISCOSITY CONTROLLING

C10-12 ALKANESOLVENT; SKIN CONDITIONING - MISCELLANEOUS

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BUTYROLACTONE appears in the CosIng inventory

The CosIng inventory lists BUTYROLACTONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BUTYROLACTONE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BUTYROLACTONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BUTYROLACTONE carries the following function designation(s):

CAS 96-48-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for BUTYROLACTONE

This page reproduces the CosIng inventory entry for BUTYROLACTONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BUTYROLACTONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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