Is TIMONACIC safe to use in EU cosmetics?

TIMONACIC is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains TIMONACIC?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5976115/10/2010

TIMONACIC

4-Thiazolidine carboxylic acid

TIMONACIC is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 34592-47-7

CAS 34592-47-7PubChem CID 93176

L-Thioproline

L-thioproline is an optically active version of thioproline having L-configuration. It has a role as a geroprotector and a metabolite. It is a thiazolidinemonocarboxylic acid and a thioproline. — ChEBI

IUPAC name: (4R)-1,3-thiazolidine-4-carboxylic acid

Molecular formula: C4H7NO2S
Molecular weight: 133.17 g/mol
Exact mass: 133.01974964 Da
XLogP3: -2.3
Topological polar surface area: 74.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 1

Also known as

(R)-Thiazolidine-4-carboxylic acidL-Thiaproline4-thiaproline(R)-4-Thiazolidinecarboxylic acid(4R)-4-Thiazolidinecarboxylic acidgamma-thioprolineThioproline, L-4-Thiazolidinecarboxylic acid, (4R)-

16 more reported names

(R)-(-)-4-Thiazolidinecarboxylic acid(R)-(-)-Thiazolidine-4-carboxylic Acid4-Thiazolidinecarboxylic acid, L-Timonacic, (R)-CCRIS 3646EINECS 252-106-3KL096K0KXL4-Thiazolidinecarboxylic acid, (R)-TIMONACIC, (-)-CHEBI:45171(4R)-1,3-thiazolidin-3-ium-4-carboxylateRefChem:7981322756-91-4L-4-Thiazolidinecarboxylic acidH-Thz-OH(4R)-thiazolidine-4-carboxylic acid

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External database identifiers

ChEBI:CHEBI:45171
ChEMBL:CHEMBL1235440
PubMed:21547360
PubMed:20221839

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 444-27-9

CAS 444-27-9PubChem CID 9934

Timonacic

Thioproline is a sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom. It has a role as an antioxidant, an antidote and a hepatoprotective agent. It is a sulfur-containing amino acid, a thiazolidinemonocarboxylic acid and a non-proteinogenic alpha-amino acid. It is a tautomer of a thioproline zwitterion. — ChEBI

IUPAC name: 1,3-thiazolidine-4-carboxylic acid

Molecular formula: C4H7NO2S
Molecular weight: 133.17 g/mol
Exact mass: 133.01974964 Da
XLogP3: -2.3
Topological polar surface area: 74.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Thiazolidine-4-carboxylic acid4-THIAZOLIDINECARBOXYLIC ACIDDetoxepaHepalidineThioprolineThiaprolineTiazolidinNorgamem

16 more reported names

DL-Thiaproline4-CarboxythiazolidineNorgamenTimonacicoHeparegenTimonacicumNSC-25855HepacomDL-Thiazolidinecarboxylic acidAcide thiazolidine-4-carboxyliqueAcide DL thiazolidine carboxylique-4E5913T3IBLCHEBI:64564gamma-thiaprolineRefChem:8981274-thiazolidine carboxylic acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:64564
ChEMBL:CHEMBL358722
PubMed:22799571
PubMed:22645409
PubMed:22606194
PubMed:22470451
PubMed:22412715
PubMed:22412481
PubMed:22398899
PubMed:22219918
PubMed:22199796
PubMed:22199780
PubMed:22199734
PubMed:22199728

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TIMONACIC

INCI name

TIMONACIC

Description

4-Thiazolidine carboxylic acid

Record provenance

Inventory reference: 59761
Imported identity: TIMONACIC
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TIMONACIC

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Key data

CAS

444-27-9 / 34592-47-7

207-146-6 / 252-106-3

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28876 · TIMONACIC

Ingredients with overlapping formulation functions

TILIA TOMENTOSA BUD EXTRACTHAIR CONDITIONING, PLASTICISER, SKIN CONDITIONING

TILIA TOMENTOSA EXTRACTSKIN CONDITIONING

TILIROSIDESKIN CONDITIONING

TILLANDSIA USNEOIDES EXTRACTSKIN CONDITIONING

TIMOSAPONIN A3SKIN CONDITIONING, SKIN PROTECTING

TINOSPORA CORDIFOLIA EXTRACTSKIN CONDITIONING

TINOSPORA CORDIFOLIA ROOT EXTRACTSKIN CONDITIONING

TINOSPORA CORDIFOLIA ROOT/STEM EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TIMONACIC appears in the CosIng inventory

The CosIng inventory lists TIMONACIC as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TIMONACIC is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TIMONACIC is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TIMONACIC carries the following function designation(s):

SKIN CONDITIONING

CAS 444-27-9 / 34592-47-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for TIMONACIC

This page reproduces the CosIng inventory entry for TIMONACIC from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TIMONACIC and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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