What does the restriction note for PRASTERONE mean?

The restriction field for PRASTERONE reads: II/37. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 53-43-0?

CAS 53-43-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PRASTERONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5838615/10/2010

PRASTERONE

Androst-5-en-17-one, 3-hydroxy, (3-beta)

PRASTERONE is linked to 1 EU annex record on this page. Inventory note: II/37.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

Compare markets

Swipe or scroll horizontally to see every column.

Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 53-43-0

CAS 53-43-0PubChem CID 5881

Dehydroepiandrosterone

Dehydroepiandrosterone is an androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands. It has a role as an androgen, a mouse metabolite and a human metabolite. It is a 3beta-hydroxy-Delta(5)-steroid, a 17-oxo steroid and an androstanoid. — ChEBI

IUPAC name: (3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

Molecular formula: C19H28O2
Molecular weight: 288.4 g/mol
Exact mass: 288.208930132 Da
XLogP3: 3.2
Topological polar surface area: 37.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 6

Also known as

DHEAPRASTERONEDehydroisoandrosteroneAndrostenoloneDiandron3beta-hydroxyandrost-5-en-17-one17-HormoforinIntrarosa

16 more reported names

Prasterona3-beta-Hydroxy-5-androsten-17-onePrasteronumVaginorm5,6-DehydroisoandrosteroneBiolaifEM-760NSC-9896Androst-5-en-17-one, 3-hydroxy-, (3beta)-NSC9896459AG36T1BCHEBI:28689FidelinPrasteraNatrol dheaEnzymatic therapy

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28689
ChEMBL:CHEMBL90593
EPA DTXSID:DTXSID4020379
PubMed:23105433
PubMed:23087149
PubMed:23021477
PubMed:23001207
PubMed:22991188
PubMed:22985672
PubMed:22975513
PubMed:22951290
PubMed:22936264
PubMed:22916165
PubMed:22912365
PubMed:22905785

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PRASTERONE

INCI name

PRASTERONE

INN name

prasterone

Description

Androst-5-en-17-one, 3-hydroxy, (3-beta)

Record provenance

Inventory reference: 58386
Imported identity: PRASTERONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PRASTERONE

Annex II Restriction reference

Entry 37

Substances with androgenic effect

Key data

CAS

53-43-0

200-175-5

Restriction

II/37

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23234 · PRASTERONE

Ingredients with overlapping formulation functions

PPG-9-BUTETH-12HAIR CONDITIONING, SKIN CONDITIONING

PPG-9-STEARETH-3SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

PRASINOCOCCUS CAPSULATUS EXOPOLYSACCHARIDESHUMECTANT, SKIN CONDITIONING

PRASIOLA JAPONICA EXTRACTSKIN CONDITIONING, SKIN PROTECTING

PRATIA BEGONIFOLIA EXTRACTSKIN CONDITIONING

PREGNENOLONE ACETATESKIN CONDITIONING

PREMNA MOLLISSIMA LEAF/ROOT EXTRACTSKIN CONDITIONING

PREMNA SERRATIFOLIA ROOT EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PRASTERONE appears in the CosIng inventory

The CosIng inventory lists PRASTERONE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PRASTERONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PRASTERONE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for PRASTERONE reads: "II/37". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, PRASTERONE carries the following function designation(s):

SKIN CONDITIONING

CAS 53-43-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for PRASTERONE

This page combines the CosIng inventory entry for PRASTERONE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research PRASTERONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect PRASTERONE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to PRASTERONE, its identifiers or nearby name variants.