What does the restriction note for PREGNENOLONE ACETATE mean?

The restriction field for PREGNENOLONE ACETATE reads: II/300 II/390. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 1778-02-5?

CAS 1778-02-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PREGNENOLONE ACETATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3725221/11/2016

PREGNENOLONE ACETATE

Pregn-5-en-20-one, 3-(acetyloxy)-, (3.beta.)-, acetate

PREGNENOLONE ACETATE is linked to 2 EU annex records on this page. Inventory note: II/300 II/390.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

Compare markets

Swipe or scroll horizontally to see every column.

Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	2	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 1778-02-5

CAS 1778-02-5PubChem CID 2723722

Pregnenolone Acetate

Pregnenolone acetate is a steroid ester. — ChEBI

IUPAC name: [(3S,8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate

Molecular formula: C23H34O3
Molecular weight: 358.5 g/mol
Exact mass: 358.25079494 Da
XLogP3: 4.8
Topological polar surface area: 43.4 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 7

Also known as

0G0WWV404BEINECS 217-212-63beta-Hydroxypregn-5-en-20-one acetatePREGNENOLONE ACETATE [MI]NSC 64827NSC-64827PREGNENOLONE ACETATE [WHO-DD](1S,3aS,3bS,7S,9aR,9bS,11aS)-1-acetyl-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate

16 more reported names

(1S,3aS,3bS,7S,9aR,9bS,11aS)-1-acetyl-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta(a)phenanthren-7-yl acetateRefChem:868472PREGNENOLONE ACETATE [INCI]217-212-6AntofinPregn-5-en-20-one, 3-(acetyloxy)-, (3beta)-3beta-Acetoxy-5-pregnene-20-one5-Pregnen-3beta-ol-20-one acetateArtivisEnescorbPrevisone(3S,8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetateSharmonePREGN-5-EN-20-ONE, 3-(ACETYLOXY)-, (3| cent)-Pregenolone acetatePregnenolone-3-acetate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:34930
ChEMBL:CHEMBL1892286
EPA DTXSID:DTXSID3048942

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PREGNENOLONE ACETATE

INCI name

PREGNENOLONE ACETATE

Description

Pregn-5-en-20-one, 3-(acetyloxy)-, (3.beta.)-, acetate

Record provenance

Inventory reference: 37252
Imported identity: PREGNENOLONE ACETATE
Source update: 21/11/2016

European Commission CosIng source notes

Annex records for PREGNENOLONE ACETATE

Annex II Restriction reference

Entry 300

Glucocorticoids (Corticosteroids)

Annex II Restriction reference

Entry 390

Anti-androgens of steroidal structure

Key data

CAS

1778-02-5

217-212-6

Restriction

II/300 II/390

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23237 · PREGNENOLONE ACETATE

Ingredients with overlapping formulation functions

PRASINOCOCCUS CAPSULATUS EXOPOLYSACCHARIDESHUMECTANT, SKIN CONDITIONING

PRASIOLA JAPONICA EXTRACTSKIN CONDITIONING, SKIN PROTECTING

PRASTERONESKIN CONDITIONING

PRATIA BEGONIFOLIA EXTRACTSKIN CONDITIONING

PREMNA MOLLISSIMA LEAF/ROOT EXTRACTSKIN CONDITIONING

PREMNA SERRATIFOLIA ROOT EXTRACTSKIN CONDITIONING

PRIMULA DENTICULATA LEAF EXTRACTSKIN CONDITIONING

PRIMULA SIKKIMENSIS FLOWER EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PREGNENOLONE ACETATE appears in the CosIng inventory

The CosIng inventory lists PREGNENOLONE ACETATE as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PREGNENOLONE ACETATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PREGNENOLONE ACETATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for PREGNENOLONE ACETATE reads: "II/300 II/390". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, PREGNENOLONE ACETATE carries the following function designation(s):

SKIN CONDITIONING

CAS 1778-02-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for PREGNENOLONE ACETATE

This page combines the CosIng inventory entry for PREGNENOLONE ACETATE with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research PREGNENOLONE ACETATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect PREGNENOLONE ACETATE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to PREGNENOLONE ACETATE, its identifiers or nearby name variants.