Is CHRYSIN safe to use in EU cosmetics?

CHRYSIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 480-40-0?

CAS 480-40-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CHRYSIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5528115/10/2010

CHRYSIN

5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-one

CHRYSIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 480-40-0

CAS 480-40-0PubChem CID 5281607

Chrysin

Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent, an anti-inflammatory agent, a plant metabolite and an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor. It is a dihydroxyflavone and a 7-hydroxyflavonol. — ChEBI

IUPAC name: 5,7-dihydroxy-2-phenylchromen-4-one

Molecular formula: C15H10O4
Molecular weight: 254.24 g/mol
Exact mass: 254.05790880 Da
XLogP3: 2.1
Topological polar surface area: 66.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

5,7-DihydroxyflavoneChrysine4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-phenyl-5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-oneFLAVONE, 5,7-DIHYDROXY-NSC-4074363CN01F5ZJ5CHEBI:75095

16 more reported names

5,7-dihydroxy-flavoneRefChem:5686207-549-75,7-Dihydroxy-2-phenyl-4H-chromen-4-one5,7-Dihydroxy-2-phenyl-chromen-4-oneCHEMBL117Crysin5,7-Dihydroxy-2-phenyl-4H-benzo(b)pyran-4-oneChrysin 99+%CAS-480-40-0Chrysinic acidSR-01000765660EINECS 207-549-7NSC 407436BRN 0233276UNII-3CN01F5ZJ5

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:75095
ChEMBL:CHEMBL117
EPA DTXSID:DTXSID1022396
PubMed:40534331
PubMed:38432408
PubMed:38403145
PubMed:37453011
PubMed:37348668
PubMed:37263553
PubMed:37224935
PubMed:37057715
PubMed:36114367
PubMed:35435491
PubMed:34774662
PubMed:33405908

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CHRYSIN

INCI name

CHRYSIN

Description

5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-one

Record provenance

Inventory reference: 55281
Imported identity: CHRYSIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CHRYSIN

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching CHRYSIN or related substances.

Key data

CAS

480-40-0

207-549-7

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6331 · CHRYSIN

Ingredients with overlapping formulation functions

CHRYSANTHEMUM ZAWADSKII EXTRACTSKIN CONDITIONING

CHRYSANTHEMUM ZAWADSKII FLOWER EXTRACTANTIOXIDANT, HUMECTANT, SKIN CONDITIONING

CHRYSANTHEMUM ZAWADSKII FLOWER/LEAF/STEM EXTRACTSKIN CONDITIONING

CHRYSEOBACTERIUM SP. MK-8 FERMENT FILTRATEHUMECTANT, SKIN CONDITIONING

CHRYSOCOLLASKIN CONDITIONING

CHYMOTRYPSINSKIN CONDITIONING

CIBOTIUM BAROMETZ OILSKIN CONDITIONING

CICADA EXTRACTANTIOXIDANT, ASTRINGENT, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CHRYSIN appears in the CosIng inventory

The CosIng inventory lists CHRYSIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CHRYSIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CHRYSIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CHRYSIN carries the following function designation(s):

SKIN CONDITIONING

CAS 480-40-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for CHRYSIN

This page reproduces the CosIng inventory entry for CHRYSIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CHRYSIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect CHRYSIN and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to CHRYSIN, its identifiers or nearby name variants.