Is CARNOSINE safe to use in EU cosmetics?

CARNOSINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 305-84-0?

CAS 305-84-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CARNOSINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5508815/10/2010

CARNOSINE

L-histidine, N-beta-alanyl

CARNOSINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 305-84-0

CAS 305-84-0PubChem CID 439224

Carnosine

Carnosine is a dipeptide that is the N-(beta-alanyl) derivative of L-histidine. It has a role as a geroprotector, an antioxidant, an antineoplastic agent, an anticonvulsant, a neuroprotective agent, a mouse metabolite, a human metabolite and a Daphnia magna metabolite. It is a conjugate acid of a carnosinate. It is a tautomer of a carnosine zwitterion. — ChEBI

IUPAC name: (2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid

Molecular formula: C9H14N4O3
Molecular weight: 226.23 g/mol
Exact mass: 226.10659032 Da
XLogP3: -4.0
Topological polar surface area: 121.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 1

Also known as

L-Carnosinebeta-Alanyl-L-histidineIgnotineKarnozinKarnozznL-Histidine, beta-alanyl-(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acidNalpha-(beta-alanyl)-L-histidine

16 more reported names

L-HISTIDINE, N-beta-ALANYL-8HO6PVN24WCHEBI:15727N-beta-alanyl-L-histidineNSC-524045(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acidL Carnosinebeta AlanylhistidineHydrochloride, CarnosineRefChem:574695(2S)-2-(3-azaniumylpropanoylamino)-3-(1H-imidazol-5-yl)propanoate(2S)-2-((3-Amino-1-Oxopropyl)Amino)-3-(3H-Imidazol-4-Yl)Propanoic Acid206-169-9(3-aminopropanoyl)-L-histidineN-2-MN-b-alanyl-L-Histidine

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:15727
ChEMBL:CHEMBL242948
EPA DTXSID:DTXSID80879594
PubMed:33124720
PubMed:31073693
PubMed:23105891
PubMed:23079503
PubMed:23075550
PubMed:23029420
PubMed:22961384
PubMed:22943141
PubMed:22910804
PubMed:22890441
PubMed:22860191
PubMed:22852051

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CARNOSINE

INCI name

CARNOSINE

Description

L-histidine, N-beta-alanyl

Record provenance

Inventory reference: 55088
Imported identity: CARNOSINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CARNOSINE

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching CARNOSINE or related substances.

Key data

CAS

305-84-0

206-169-9

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#5521 · CARNOSINE

Ingredients with overlapping formulation functions

CARNITINEANTISTATIC, CLEANSING, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - F…

CARNITINE FUMARATESKIN CONDITIONING

CARNITINE HCLHUMECTANT, SKIN CONDITIONING

CARNITINE HYDROXYCITRATESKIN CONDITIONING

CARPINUS BETULUS BUD EXTRACTSKIN CONDITIONING

CARPINUS BETULUS FLOWER EXTRACTSKIN CONDITIONING

CARPINUS CORDATA LEAF EXTRACTSKIN CONDITIONING

CARPINUS TSCHONOSKII LEAF EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, HAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CARNOSINE appears in the CosIng inventory

The CosIng inventory lists CARNOSINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CARNOSINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CARNOSINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CARNOSINE carries the following function designation(s):

SKIN CONDITIONING

CAS 305-84-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for CARNOSINE

This page reproduces the CosIng inventory entry for CARNOSINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CARNOSINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect CARNOSINE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to CARNOSINE, its identifiers or nearby name variants.