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CAS 6976-37-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5469715/10/2010

BIS-HYDROXYETHYL TROMETHAMINE

2-[bis(2-Hydroxyethyl)amino]-2-hydroxymethyl-1,3-propanediol

BIS-HYDROXYETHYL TROMETHAMINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 6976-37-0

CAS 6976-37-0PubChem CID 81462

Bistris

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 C. It has a role as a buffer. It is functionally related to a member of tris. — ChEBI

IUPAC name: 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol

Molecular formula: C8H19NO5
Molecular weight: 209.24 g/mol
Exact mass: 209.12632271 Da
XLogP3: -3.3
Topological polar surface area: 104.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

bis-tris2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diolQ1XC3631CPCHEBI:412501,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-NSC-24868NSC-119932

16 more reported names

1,3-Propanediol, 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-2,2-Bis[hydroxymethyl]-2,2',2''-nitrilotriethanolRefChem:569580bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane2-(bis(2-hydroxyethyl)amino)-2(hydroxymethyl)-1,3-propanediol2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)METHANE230-237-7686-880-2Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methaneBIS-TRIS BUFFERBis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2,2-Bis(hydroxymethyl)-2,2,2-nitrilotriethanol2-(Bis(2-hydroxyethyl)amino))-2-hydroxymethyl-1,3-propanediolBis-(2-hydroxyethyl)aminotris(hydroxymethyl)methaneBistris; NSC 119932; NSC 24868; NuPage Bis-Tris

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:41250
EPA DTXSID:DTXSID6064537
PubMed:22701303
PubMed:22693585
PubMed:22693568
PubMed:22693546
PubMed:22685544
PubMed:22675529
PubMed:22675482
PubMed:22675237
PubMed:22666369
PubMed:22666364
PubMed:22666335
PubMed:22666151

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BIS-HYDROXYETHYL TROMETHAMINE

INCI name

BIS-HYDROXYETHYL TROMETHAMINE

Description

2-[bis(2-Hydroxyethyl)amino]-2-hydroxymethyl-1,3-propanediol

Record provenance

Inventory reference: 54697
Imported identity: BIS-HYDROXYETHYL TROMETHAMINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for BIS-HYDROXYETHYL TROMETHAMINE

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Key data

CAS

6976-37-0

230-237-7

Restriction

—

Function

BUFFERING: Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#3700 · BIS-HYDROXYETHYL TROMETHAMINE

Ingredients with overlapping formulation functions

AZELAIC ACIDBUFFERING, FRAGRANCE

BABASSU ACIDBUFFERING, CLEANSING, EMULSION STABILISING

BAKUHANANTIMICROBIAL, ASTRINGENT, BLEACHING, BUFFERING, HAIR CONDITIONING, SKIN CONDITIONING

BENZILIC ACIDBUFFERING

BIS-METHOXY PEG-114 POLYCAPROLACTONE DIOL/IPDI COPOLYMERBUFFERING, FILM FORMING, HAIR CONDITIONING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYI…

BISMUTH CITRATEBUFFERING, CHELATING, HAIR DYEING

BORIC ACIDANTIMICROBIAL, BUFFERING, DENATURANT

BUTYL DIETHANOLAMINEBUFFERING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BIS-HYDROXYETHYL TROMETHAMINE appears in the CosIng inventory

The CosIng inventory lists BIS-HYDROXYETHYL TROMETHAMINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BIS-HYDROXYETHYL TROMETHAMINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BIS-HYDROXYETHYL TROMETHAMINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BIS-HYDROXYETHYL TROMETHAMINE carries the following function designation(s):

BUFFERING

CAS 6976-37-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BIS-HYDROXYETHYL TROMETHAMINE

This page reproduces the CosIng inventory entry for BIS-HYDROXYETHYL TROMETHAMINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BIS-HYDROXYETHYL TROMETHAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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