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InventoryRef 5417315/10/2010

1,4-BUTANEDIOL

Butane - 1,4 - diol

1,4-BUTANEDIOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 110-63-4
CAS 110-63-4PubChem CID 8064

1,4-Butanediol

Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16C) with a high boiling point (230C), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF). It has a role as a protic solvent, a prodrug and a neurotoxin. It is a glycol and a butanediol. — ChEBI

IUPAC name
butane-1,4-diol
Molecular formula
C4H10O2
Molecular weight
90.12 g/mol
Exact mass
90.068079557 Da
XLogP3
-0.8
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Tetramethylene glycol1,4-Butylene glycol1,4-Dihydroxybutane1,4-Tetramethylene glycolSucol BTetramethylene 1,4-diolDIOL 14B1,4-BD
16 more reported names
Agrisynth B1D7XOO2LE6G3NSC-406696CHEBI:41189RefChem:6711203-786-5615-930-8HO(CH2)4OHNSC 406696HOCH2CH2CH2CH2OH1,4-butane-d8-diolBDOBU1CAS-110-63-4CCRIS 5984HSDB 1112
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8064

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 10.4% (112 of 1080) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (89.6%): Harmful if swallowed [Warning Acute toxicity, oral]; H336 (70.6%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P270, P271, P301+P317, P304+P340, P319, P330, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1080 reports by companies from 32 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 112 of 1080 reports by companies.; There are 31 notifications provided by 968 of 1080 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P261, P264, P270, P271, P301+P317, P304+P340, P319, P330, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P261, P264, P270, P271, P301+P317, P304+P340, P319, P330, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Conclusion: The Panel also concluded that the available data are insufficient to make a determination that 1,4-Butanediol... is safe under the intended conditions of use in cosmetic formulations. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): The available data are insufficient to support safety Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: 1,4-Butanediol is a colorless, oily liquid. It is used as an industrial solvent, intermediate in organic synthesis, and polymer feedstock. Two studies have been identified concerning the experimental use of 1,4-butanediol as a sedative. HUMAN STUDIES: It was reported that sleep is induced by intravenous administration or by infusion. Undesirable side-effects which may occur include restlessness and clonic spasms of the muscle of the extremities. Cases of abuse and fatal intoxication have been reported. ANIMAL STUDIES: Gauze patches with undiluted 1,4-butanediol were applied to the intact and abraded skin of rabbits with occlusive dressing for 24 hours. After 1, 24, 48 and 72 hours, no reaction was observed on the intact and abraded skin. The main signs of toxicity seen in mice and rats were accelerated breathing, dyspnea, spasmodic breathing, bradycardia, exsiccosis, exophthalmus, apathy, hyperreflexia, hyporeflexia, areflexia, ataxia, atonia, twitching, reduced motility, analgesia, lying on the side, loss of righting reflexes, sedation, narcosis, hair loss and ruffled fur. Death occurred within 24 hours. Respiratory failure was thought to be the cause of de Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 1,4-butanediol(SRC), using a log Kow of -0.83(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1,4-butanediol is expected to have very high mobility in soil(SRC). Volatilization of 1,4-butanediol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-9 atm-cu m/mole(SRC), based upon its vapor pressure, 0.0105 mm Hg(3), and assigned value for water solubility of 1X10+6 mg/L (miscible)(4). 1,4-Butanediol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). An 83% of Theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1,4-butanediol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.2X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 0.0105 mm Hg(4), assigned value for water solubility of 1X10+6 mg/L (miscible)(5). 1,4-Butanediol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow of -0.83(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. An 83% of Theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,4-butanediol, which has a vapor pressure of 0.0105 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,4-butanediol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 10 hours(SRC), calculated from its rate constant of 3.67X10-11 cu cm/molecule-sec(3). 1,4-Butanediol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Intermediate; Hardener; Surface modifier; Plasticizer; Not Known or Reasonably Ascertainable; Monomers; Wrinkle resisting agent; Solvent Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 1,4-BUTANEDIOL

INCI name

1,4-BUTANEDIOL

Description

Butane - 1,4 - diol

Record provenance

Inventory reference
54173
Imported identity
1,4-BUTANEDIOL
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
110-63-4
EC
203-786-5
Restriction
—
Function
SOLVENT
Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#113 · 1,4-BUTANEDIOL

Ingredients with overlapping formulation functions

1,10-DECANEDIOLSOLVENT
1,2,6-HEXANETRIOLHUMECTANT, SOLVENT, VISCOSITY CONTROLLING
1,2-BUTANEDIOLHUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING
1,2-HEXANEDIOLSKIN CONDITIONING, SOLVENT
1,5-PENTANEDIOLSOLVENT
1-NITROPROPANESOLVENT
2,3-BUTANEDIOLFRAGRANCE, HUMECTANT, SKIN CONDITIONING, SOLVENT
2-ETHYLHEXYLALSOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How 1,4-BUTANEDIOL appears in the CosIng inventory

The CosIng inventory lists 1,4-BUTANEDIOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

1,4-BUTANEDIOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

1,4-BUTANEDIOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 1,4-BUTANEDIOL carries the following function designation(s):

CAS 110-63-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for 1,4-BUTANEDIOL

This page reproduces the CosIng inventory entry for 1,4-BUTANEDIOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 1,4-BUTANEDIOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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