InventoryRef 4087402/03/2011
NEROL
cis-3,7-Dimethyl-2,6-octadien-1-ol
NEROL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 106-25-2PubChem CID 643820
Nerol
Nerol is the (2Z)-stereoisomer of 3,7-dimethylocta-2,6-dien-1-ol. It has been isolated from the essential oils from plants like lemon grass. It has a role as a volatile oil component, a fragrance and a plant metabolite. — ChEBI
- IUPAC name
- (2Z)-3,7-dimethylocta-2,6-dien-1-ol
- Molecular formula
- C10H18O
- Molecular weight
- 154.25 g/mol
- Exact mass
- 154.135765193 Da
- XLogP3
- 2.9
- Topological polar surface area
- 20.2 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Neryl alcoholcis-Geraniol(Z)-3,7-dimethylocta-2,6-dien-1-ol(Z)-Geraniolcis-3,7-Dimethyl-2,6-octadien-1-ol(Z)-Nerol2,6-Octadien-1-ol, 3,7-dimethyl-, (2Z)-Nerol 900
16 more reported names
Z-Geraniol2-cis-3,7-Dimethyl-2,6-octadien-1-olFEMA No. 2770NSC-46105CHEBI:294523,7-Dimethyl-2,6-octadien-1-ol, cis-cis-2,6-dimethyl-2,6-octadien-8-ol(2Z)-3,7-Dimethyl-2,6-octadien-1-ol3,7-Dimethyl-2,6-octadien-1-ol, (Z)-38G5P53250BETA-NEROLRefChem:165502203-378-7Nerol (natural)(Z)-3,7-dimethyl-2,6-octadien-1-ol2,6-Octadien-1-ol, 3,7-dimethyl-, (Z)-
External database identifiers
- ChEBI:CHEBI:29452
- ChEMBL:CHEMBL452683
- EPA DTXSID:DTXSID3026728
- PubMed:11731906
- PubMed:7739729
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:29452
nerol
The (2Z)-stereoisomer of 3,7-dimethylocta-2,6-dien-1-ol. It has been isolated from the essential oils from plants like lemon grass.
- Formula
- C10H18O
- Average mass
- 154.253 g/mol
- Monoisotopic mass
- 154.13577 Da
- Formal charge
- 0
- 3,7-dimethylocta-2,6-dien-1-ol — is a (CHEBI:24221)
- fragrance — has role (CHEBI:48318)
- volatile oil component — has role (CHEBI:27311)
- plant metabolite — has role (CHEBI:76924)
- fragrance — has role (CHEBI:48318)
- volatile oil component — has role (CHEBI:27311)
- plant metabolite — has role (CHEBI:76924)
- 3,7-dimethylocta-2,6-dien-1-ol — is a (CHEBI:24221)
Additional curated names
(2Z)-3,7-dimethylocta-2,6-dien-1-ol2-cis-3,7-dimethyl-2,6-octadien-1-ol(2Z)-3,7-dimethyl-2,6-octadien-1-olcis-3,7-dimethyl-2,6-octadien-1-olcis-geraniol(Z)-3,7-dimethyl-2,6-octadien-1-ol(Z)-geraniolNerolneryl alcohol(Z)-3,7-Dimethylocta-2,6-dien-1-ol
Cross-references from this source
- CAS: 106-25-2 — KEGG COMPOUND
- CAS: 106-25-2 — ChemIDplus
- CAS: 106-25-2 — NIST Chemistry WebBook
- REGISTRY_NUMBER: 1722454 — Reaxys
- REGISTRY_NUMBER: 1722455 — Beilstein
- MANUAL_X_REF: C00000855 — KNApSAcK
- MANUAL_X_REF: C09871 — KEGG COMPOUND
- MANUAL_X_REF: CN103342627 — Patent
- MANUAL_X_REF: CPD-7978 — MetaCyc
- MANUAL_X_REF: LMPR0102010010 — LIPID MAPS
- MANUAL_X_REF: MX2013000640 — Patent
- MANUAL_X_REF: Nerol — Wikipedia
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-10-03. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match643820
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 225 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: BP: 224-225 at 745 mm Hg; 125 °C at 25 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 103.00 to 105.00 °C. @ 9.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 227 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: Colorless oily liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 9.8756 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Density: 0.8813 at 15 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.875-0.880 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Flash Point: Flash Point: 107.78 °C /226 °F (closed cup) Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = 3.47 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 3.47 Source: Human Metabolome Database (HMDB)
- Melting Point: <-15 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: Crystals; mp: 118 °C /Nerol tetrabromide/ Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: Needles from petroleum ether; mp: 84-86 °C /Nerol allophanate/ Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: < -15 °C Source: Human Metabolome Database (HMDB)
- Odor: Sweet rose Source: Hazardous Substances Data Bank (HSDB)
- Odor: The odor of pure nerol is sweet, rosy refreshing and "wet" seashore Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: CBI; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Liquid with an odor of sweet rose; [Merck Index] Colorless to pale yellow liquid with a pleasant odor; [CAMEO] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: Colourless liquid; fresh, sweet, rose-like aroma Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: Index of refraction: 1.4746 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.467-1.478 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: In water, 1311 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 531 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Very soluble in ethanol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in absolute alcohol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in alcohol, chloroform, ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 0.531 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Insoluble in water; soluble in chloroform, ether, most fixed oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 0.03 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 3.0X01-2 mm Hg at 25 °C (extrapolated) Source: Hazardous Substances Data Bank (HSDB)
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (2 of 2141) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (97%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (78.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (63.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (33%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2141 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 2141 reports by companies.; There are 26 notifications provided by 2139 of 2141 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264, P264+P265, P272, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
- GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Substances Data Bank (HSDB)
- Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
- Toxicity Summary: IDENTIFICATION AND USE: Nerol is a colorless oily fluid. Nerol is reported to be found in neroli oil (with geraniol) and in many essential oils. It used as a base for the manufacture of perfumes and in fragrances. HUMAN EXPOSURE AND TOXICITY: A single sensitization test was carried out on 25 volunteers. The material was tested at a concentration of 4% in petrolatum and produced no sensitization reactions. In other study, nerol was utilized in a closed patch test on the back or forearm of 314 subjects for 24-48 hr. Slight erythema was demonstrated in 10 (3.19%) subjects. In an in vitro chromosome aberration test in cultured human lymphocytes nerol was not clastogenic with and without metabolic activation. ANIMAL STUDIES: Eye irritant effects were observed in rabbits. Slight skin irritation was observed in guinea pigs and rabbits. Respiratory irritation was assessed in mice by recording their respiratory rate when exposed to nerol. Mice were exposed to the test material for 1 min using a nebulizer for aerosolization in a 2600 mL chamber. Mild to moderate decrease in the respiratory rate was observed, and the ED25 (dose at which there is a 25% reduction in the respiratory rate) was ca Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 90 was calculated in fish for nerol(SRC), using a log Kow of 3.47(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 94(SRC), determined from a structure estimation method(2), indicates that nerol is expected to have high mobility in soil(SRC). Volatilization of nerol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-5 atm-cu m/mole(SRC), derived from its extrapolated vapor pressure, 0.03 mm Hg(2), and water solubility, 531 mg/L(3). Even though the vapor pressure is low environmentally at standard temperature and pressure, there is a detectable odor; therefore, nerol may volatilize from dry soil(SRC). Utilizing the OECD 301D test (closed bottle), 80% of the Theoretical BOD was reached in 4 weeks(5) indicating that biodegradation is an important environmental fate process. Two screening tests found mixtures of nerol and geraniol to be readily biodegradable based on 100% degradation after 28 and 15 days(6). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 94(SRC), determined from a structure estimation method(2), indicates that nerol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.2X10-5 atm-cu m/mole(SRC), derived from its extrapolated vapor pressure, 0.03 mm Hg(2), and water solubility, 531 mg/L(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4.1 and 34 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 90(SRC), from its log Kow of 3.47(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Utilizing the OECD 301D test (closed bottle) and a river water inoculum, 80% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is an important environmental fate process. Two screening tests found mixtures of nerol and geraniol to be readily biodegradable based on 100% degradation after 28 and 15 days(8). Nerol is not expected to undergo hydrol Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), nerol, which has an extrapolated vapor pressure of 0.03 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase nerol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.1 hours(SRC), calculated from its rate constant of 1.8X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase nerol is also degraded in the atmosphere by reaction with ozone(SRC); the half-life for this reaction in air is estimated to be 19 minutes(SRC), calculated from its rate constant of 8.6X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase nerol is degraded in the atmosphere by reaction with nitrate radicals(SRC); the half-life for this reaction in air is estimated to be 4 minutes(SRC), calculated from a rate constant of 1.66X10-11 cu cm/molecule-sec at 24 °C for the analogous compound geraniol(3). The nitrate radical (NO3) is the dominan Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Intermediates; Fragrance; Odor agents Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Intermediates; Other; Fragrance; Odor agents Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Present in many essential oils; Used as a base for perfume manufacture; [Merck Index] Also used as a flavoring agent; [CAMEO] The cis-isomer of geraniol; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Uses: In public use since the 1920's. Use in fragrances in the USA amounts to approximately 20,000 lbs per year. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Base for manufacture of perfumes. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Reported uses (ppm):; Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association, 1994) [Table#8244] Source: Hazardous Substances Data Bank (HSDB)
- Uses: A wide variety of nerol esters are in use as fragrance ingredients. A considerable amount of nerol is used internally by the producers as intermediates for manufacture of other terpene products, particularly citral, ionones, methylionones, citronellol, citronellal, hydroxycitronellal, menthol, and carotenoids. Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for Nerol (7 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for NEROL
INCI name
NEROL
Description
cis-3,7-Dimethyl-2,6-octadien-1-ol
Record provenance
- Inventory reference
- 40874
- Imported identity
- NEROL
- Source update
- 02/03/2011
Annex records for NEROL
Key data
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How NEROL appears in the CosIng inventory
The CosIng inventory lists NEROL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
NEROL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
NEROL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, NEROL carries the following function designation(s):
CAS 106-25-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for NEROL
This page reproduces the CosIng inventory entry for NEROL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research NEROL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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