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CAS 106-25-2

CAS 106-25-2 matches 0 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 106-25-2
CAS 106-25-2PubChem CID 643820

Nerol

Nerol is the (2Z)-stereoisomer of 3,7-dimethylocta-2,6-dien-1-ol. It has been isolated from the essential oils from plants like lemon grass. It has a role as a volatile oil component, a fragrance and a plant metabolite. — ChEBI

IUPAC name
(2Z)-3,7-dimethylocta-2,6-dien-1-ol
Molecular formula
C10H18O
Molecular weight
154.25 g/mol
Exact mass
154.135765193 Da
XLogP3
2.9
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Neryl alcoholcis-Geraniol(Z)-3,7-dimethylocta-2,6-dien-1-ol(Z)-Geraniolcis-3,7-Dimethyl-2,6-octadien-1-ol(Z)-Nerol2,6-Octadien-1-ol, 3,7-dimethyl-, (2Z)-Nerol 900
16 more reported names
Z-Geraniol2-cis-3,7-Dimethyl-2,6-octadien-1-olFEMA No. 2770NSC-46105CHEBI:294523,7-Dimethyl-2,6-octadien-1-ol, cis-cis-2,6-dimethyl-2,6-octadien-8-ol(2Z)-3,7-Dimethyl-2,6-octadien-1-ol3,7-Dimethyl-2,6-octadien-1-ol, (Z)-38G5P53250BETA-NEROLRefChem:165502203-378-7Nerol (natural)(Z)-3,7-dimethyl-2,6-octadien-1-ol2,6-Octadien-1-ol, 3,7-dimethyl-, (Z)-
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:29452

nerol

The (2Z)-stereoisomer of 3,7-dimethylocta-2,6-dien-1-ol. It has been isolated from the essential oils from plants like lemon grass.

Formula
C10H18O
Average mass
154.253 g/mol
Monoisotopic mass
154.13577 Da
Formal charge
0
  • 3,7-dimethylocta-2,6-dien-1-ol — is a (CHEBI:24221)
  • fragrance — has role (CHEBI:48318)
  • volatile oil component — has role (CHEBI:27311)
  • plant metabolite — has role (CHEBI:76924)
  • fragrance — has role (CHEBI:48318)
  • volatile oil component — has role (CHEBI:27311)
  • plant metabolite — has role (CHEBI:76924)
  • 3,7-dimethylocta-2,6-dien-1-ol — is a (CHEBI:24221)
Additional curated names
(2Z)-3,7-dimethylocta-2,6-dien-1-ol2-cis-3,7-dimethyl-2,6-octadien-1-ol(2Z)-3,7-dimethyl-2,6-octadien-1-olcis-3,7-dimethyl-2,6-octadien-1-olcis-geraniol(Z)-3,7-dimethyl-2,6-octadien-1-ol(Z)-geraniolNerolneryl alcohol(Z)-3,7-Dimethylocta-2,6-dien-1-ol
Cross-references from this source
  • CAS: 106-25-2 — KEGG COMPOUND
  • CAS: 106-25-2 — ChemIDplus
  • CAS: 106-25-2 — NIST Chemistry WebBook
  • REGISTRY_NUMBER: 1722454 — Reaxys
  • REGISTRY_NUMBER: 1722455 — Beilstein
  • MANUAL_X_REF: C00000855 — KNApSAcK
  • MANUAL_X_REF: C09871 — KEGG COMPOUND
  • MANUAL_X_REF: CN103342627 — Patent
  • MANUAL_X_REF: CPD-7978 — MetaCyc
  • MANUAL_X_REF: LMPR0102010010 — LIPID MAPS
  • MANUAL_X_REF: MX2013000640 — Patent
  • MANUAL_X_REF: Nerol — Wikipedia

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-10-03. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match643820

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (2 of 2141) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (97%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (78.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (63.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (33%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2141 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 2141 reports by companies.; There are 26 notifications provided by 2139 of 2141 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P261, P264, P264+P265, P272, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Nerol is a colorless oily fluid. Nerol is reported to be found in neroli oil (with geraniol) and in many essential oils. It used as a base for the manufacture of perfumes and in fragrances. HUMAN EXPOSURE AND TOXICITY: A single sensitization test was carried out on 25 volunteers. The material was tested at a concentration of 4% in petrolatum and produced no sensitization reactions. In other study, nerol was utilized in a closed patch test on the back or forearm of 314 subjects for 24-48 hr. Slight erythema was demonstrated in 10 (3.19%) subjects. In an in vitro chromosome aberration test in cultured human lymphocytes nerol was not clastogenic with and without metabolic activation. ANIMAL STUDIES: Eye irritant effects were observed in rabbits. Slight skin irritation was observed in guinea pigs and rabbits. Respiratory irritation was assessed in mice by recording their respiratory rate when exposed to nerol. Mice were exposed to the test material for 1 min using a nebulizer for aerosolization in a 2600 mL chamber. Mild to moderate decrease in the respiratory rate was observed, and the ED25 (dose at which there is a 25% reduction in the respiratory rate) was ca Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 90 was calculated in fish for nerol(SRC), using a log Kow of 3.47(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 94(SRC), determined from a structure estimation method(2), indicates that nerol is expected to have high mobility in soil(SRC). Volatilization of nerol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-5 atm-cu m/mole(SRC), derived from its extrapolated vapor pressure, 0.03 mm Hg(2), and water solubility, 531 mg/L(3). Even though the vapor pressure is low environmentally at standard temperature and pressure, there is a detectable odor; therefore, nerol may volatilize from dry soil(SRC). Utilizing the OECD 301D test (closed bottle), 80% of the Theoretical BOD was reached in 4 weeks(5) indicating that biodegradation is an important environmental fate process. Two screening tests found mixtures of nerol and geraniol to be readily biodegradable based on 100% degradation after 28 and 15 days(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 94(SRC), determined from a structure estimation method(2), indicates that nerol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.2X10-5 atm-cu m/mole(SRC), derived from its extrapolated vapor pressure, 0.03 mm Hg(2), and water solubility, 531 mg/L(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4.1 and 34 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 90(SRC), from its log Kow of 3.47(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Utilizing the OECD 301D test (closed bottle) and a river water inoculum, 80% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is an important environmental fate process. Two screening tests found mixtures of nerol and geraniol to be readily biodegradable based on 100% degradation after 28 and 15 days(8). Nerol is not expected to undergo hydrol Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), nerol, which has an extrapolated vapor pressure of 0.03 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase nerol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.1 hours(SRC), calculated from its rate constant of 1.8X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase nerol is also degraded in the atmosphere by reaction with ozone(SRC); the half-life for this reaction in air is estimated to be 19 minutes(SRC), calculated from its rate constant of 8.6X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase nerol is degraded in the atmosphere by reaction with nitrate radicals(SRC); the half-life for this reaction in air is estimated to be 4 minutes(SRC), calculated from a rate constant of 1.66X10-11 cu cm/molecule-sec at 24 °C for the analogous compound geraniol(3). The nitrate radical (NO3) is the dominan Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

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