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InventoryRef 3886415/10/2010

VALINE

2-Amino-3-methylbutanoic acid

VALINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 516-06-3
CAS 516-06-3PubChem CID 1182

DL-valine

Valine is a branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group. It has a role as a plant metabolite and a Daphnia magna metabolite. It is a branched-chain amino acid and an alpha-amino acid. It contains an isopropyl group. It is a conjugate base of a valinium. It is a conjugate acid of a valinate. — ChEBI

IUPAC name
2-amino-3-methylbutanoic acid
Molecular formula
C5H11NO2
Molecular weight
117.15 g/mol
Exact mass
117.078978594 Da
XLogP3
-2.3
Topological polar surface area
63.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Valine, DL-FEMA No. 3444D,L-VALINENSC 9755CCRIS 86044CA13A832HNSC-9755EINECS 208-220-0
16 more reported names
D,L-VALINE [FHFI]AI3-18308Valine, DLRefChem:5899872Aminoisovaleric acid, DLalphaAminoisovaleric acid, DL2Amino3methylbutyric acid, DL2Amino3methylbutanoic acid, DL208-220-02-Amino-3-methylbutanoic acid (VAN)H-DL-Val-OH2-Amino-3-methylbutanoic acid, DL-DL-.alpha.-Aminoisovaleric acidHY-W012889(+/-)-2-AMINOISOVALERIC ACIDAS-11670
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 640-68-6
CAS 640-68-6PubChem CID 71563

D-Valine

D-valine is the D-enantiomer of valine. It is a D-alpha-amino acid and a valine. It is a conjugate base of a D-valinium. It is a conjugate acid of a D-valinate. It is an enantiomer of a L-valine. It is a tautomer of a D-valine zwitterion. — ChEBI

IUPAC name
(2R)-2-amino-3-methylbutanoic acid
Molecular formula
C5H11NO2
Molecular weight
117.15 g/mol
Exact mass
117.078978594 Da
XLogP3
-2.3
Topological polar surface area
63.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
1

Also known as

(R)-ValineValine, D-D-valin(R)-2-Amino-3-methylbutyric acidEINECS 211-368-9NSC 20654D-2-Amino-3-methylbutanoic acidD-(-)-VALINE
16 more reported names
Y14I1443URNSC-20654VALINE, (-)-CHEBI:27477D-2-amino-3-methylbutyric acid2-Amino-3-methylbutanoic acid(D)(R)ValineRefChem:585124D2Amino3methylbutanoic acid(R)alphaAminoisovaleric acid(2R)-2-azaniumyl-3-methylbutanoate211-368-9InChI=1/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/sH-D-Val-OH(R)-2-Amino-3-methylbutanoic acidR-Valine
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 72-18-4
CAS 72-18-4PubChem CID 6287

L-Valine

L-valine is the L-enantiomer of valine. It has a role as a micronutrient, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is a L-alpha-amino acid, a pyruvate family amino acid, a valine and a proteinogenic amino acid. It is a conjugate base of a L-valinium. It is a conjugate acid of a L-valinate. It is an enantiomer of a D-valine. It is a tautomer of a L-valine zwitterion. — ChEBI

IUPAC name
(2S)-2-amino-3-methylbutanoic acid
Molecular formula
C5H11NO2
Molecular weight
117.15 g/mol
Exact mass
117.078978594 Da
XLogP3
-2.3
Topological polar surface area
63.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
1

Also known as

valine(S)-Valine(S)-2-Amino-3-methylbutanoic acid2-Amino-3-methylbutyric acid(S)-2-Amino-3-methylbutyric acidvalinaL-alpha-Amino-beta-methylbutyric acidL-valin
16 more reported names
Valinum(S)-alpha-Amino-beta-methylbutyric acidNSC-76038l-(+)-alpha-Aminoisovaleric acidHG18B9YRS7CHEBI:16414L-Val2-amino-3-methylbutanoate(2S)-2-amino-3-methylbutanoatel valineCHEBI:27266L-Valine HighRefChem:6509L-Valine 7429L-Valine High 7430(2S)-2-amino-3-methylbutanoate;hydron
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for VALINE

INCI name

VALINE

INN name

valine

Ph. Eur. name

valinum

Description

2-Amino-3-methylbutanoic acid

Record provenance

Inventory reference
38864
Imported identity
VALINE
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
516-06-3 / 640-68-6 / 72-18-4
EC
208-220-0 / 211-368-9 / 200-773-6
Restriction
—
Function
ANTISTATIC
Preventing and/or reducing static electricity by neutralising electrical charge on surfaces.
FRAGRANCE
Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
HAIR CONDITIONING
Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29794 · VALINE

Ingredients with overlapping formulation functions

UNDECYLENYL ALCOHOLANTISTATIC, FRAGRANCE, PERFUMING, SKIN CONDITIONING
UREAANTISTATIC, BUFFERING, HUMECTANT, SKIN CONDITIONING
VA/CROTONATES COPOLYMERANTISTATIC, BINDING, FILM FORMING, HAIR FIXING
VA/CROTONATES/VINYL NEODECANOATE COPOLYMERANTISTATIC, FILM FORMING, HAIR FIXING
VINYL DIPHENYL DIMETHICONEANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SLIP MODIFIER
WHEAT GERMAMIDOPROPALKONIUM CHLORIDEANTISTATIC, HAIR CONDITIONING
WHEAT GERMAMIDOPROPYL BETAINEANTISTATIC, CLEANSING, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - F…
WHEAT GERMAMIDOPROPYL DIMETHYLAMINEANTISTATIC, SURFACTANT - CLEANSING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How VALINE appears in the CosIng inventory

The CosIng inventory lists VALINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

VALINE is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

VALINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, VALINE carries the following function designation(s):

CAS 516-06-3 / 640-68-6 / 72-18-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for VALINE

This page reproduces the CosIng inventory entry for VALINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research VALINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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