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InventoryRef 3858315/10/2010

THIODIGLYCOL

Thiodiglycol

THIODIGLYCOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 111-48-8
CAS 111-48-8PubChem CID 5447

Thiodiglycol

Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom. It has a role as an antioxidant, a metabolite, an antineoplastic agent and a solvent. It is an aliphatic sulfide and a diol. It is functionally related to a mercaptoethanol. — ChEBI

IUPAC name
2-(2-hydroxyethylsulfanyl)ethanol
Molecular formula
C4H10O2S
Molecular weight
122.19 g/mol
Exact mass
122.04015073 Da
XLogP3
-0.6
Topological polar surface area
65.8 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2,2'-ThiodiethanolThiodiethylene glycolThiodiethanolTedegylKromfax solventBis(2-hydroxyethyl) sulfide2,2'-THIOBISETHANOLBis(2-hydroxyethyl)sulfide
16 more reported names
Ethanol, 2,2'-thiobis-Glyecine A2,2'-ThiodiglycolTiodiglicolDi(2-hydroxyethyl) sulfideBis(2-hydroxyethyl) thioetherbis(hydroxyethyl)sulfideThiodiglycolumTiodiglicolobeta-Hydroxyethyl sulfideSulfide, bis(2-hydroxyethyl)Bis(beta-hydroxyethyl) sulfidebeta,beta'-Dihydroxyethyl sulfide2,2'-sulfobisethanolbeta,beta'-Dihydroxydiethyl sulfideBis(beta-hydroxyethyl)sulfide
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5447

Attributed physical-property, hazard, environmental and use annotations.

  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Thiodiglycol is a syrupy, colorless, liquid. It is used as chemical intermediate, additive for textile printing. It is also a Schedule 2B precursor (dual-use chemicals with low to moderate commercial use and high-risk precursors) to mustard gas, sesquimustard, HT, T, and Q. It is used to manufacture ball-point pen ink. HUMAN STUDIES: The hydrolysis products of mustard gas are reported to exhibit toxicity. However, thiodiglycol, the major breakdown product, exhibits low toxicity. Therefore, it is likely that the majority of the toxic effects attributed to the hydrolysis products are due to unreacted mustard and bis(chloroethyl)polysulfides present in the original material. ANIMAL STUDIES: Acute dermal irritation was tested on rabbits. A very slight erythema was noted in 1 out of 3 animals 1 hour after treatment until day 4. The effect was completely reversible within 5 days. No cutaneous reactions were observed in the other 2 animals. In a guinea pig maximization test the challenge resulted in no skin reaction in thiodiglycol treated animals. In the Rat Inhalation Hazard Test, no mortality was reported after 8 hr exposure to a saturated atmosphere at room tem Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for thiodiglycol(SRC), using a log Kow of -0.63(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Koc values of 0.12-13.70 indicate that thiodiglycol is expected to have very high mobility in soil(1). Volatilization of thiodiglycol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.9X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Thiodiglycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.09X10-4 mm Hg at 25 °C(3). Thiodiglycol was biologically transformed to thiodiglycolic acid at zero-order rate coefficients of 9.41X10-7 to 6.26X10-6 mol/L hr in 3 soils, with lag periods of 2 to 3.75 days, biodegradation was noted in 2 other soils, but transformation rates were not reported(1). The optimum pH for the biodegradation of thiodiglycol in soil has been reported as 8.25(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Koc values of 0.12-13.70(1) indicate that thiodiglycol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(2) based upon an estimated Henry's Law constant of 1.9X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Thiodiglycol did not undergo hydrolysis at pH 4, 7 or 11(1). According to a classification scheme(4), an estimated BCF of 3(SRC), from its log Kow of -0.63(5) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low. Thiodiglycol did not undergo photolysis in aqueous solution after irradiation by sunlight for 14 days(1). Based on studies done in aerobic sludge with 19% biodegradation in 4 weeks(6), anaerobic sludge with 42% biodegradation in 185 days(7) and in soil where biodegradation was noted in 5 soils(1), biodegradation may be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), thiodiglycol, which has a vapor pressure of 5.09X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase thiodiglycol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 hours(SRC), calculated from its rate constant of 2.8X10-11 cu cm/molecule-sec at 25 °C(SRC), that was derived using a structure estimation method(3). Thiodiglycol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: A hydrolysis product of sulfur mustard (chemical weapon); Used as an intermediate for elastomers and antioxidants, a solvent for dyes in textile printing, to make ink for ball-point pens, and a precursor to mustard gas; Also used in the paint, lacquer, and varnish industry; in the polymers industry; and as a fixing agent, process regulator, and stabilizer; [HSDB] Used to make pulp, paper products, furniture, paints, pigments, dyestuffs, varnishes, coatings, and inks; Also used as a solvent for coloring paper, a softener for special rubbers, and possibly as an antioxidant in cosmetics; [OECD SIDS: Thiodiglycol - 2004] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Restricted Notes: Manufacture and export strictly controlled under the International Chemical Weapons Convention (can be used to make sulfur mustard); [OECD SIDS: Thiodiglycol - 2004] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Pulp and Paper Processing [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Intermediate for elastomers and antioxidants; solvent for dyes in textile printing. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Thiodiglycol is used as a precursor for sulfur mustard ... It is also an important primary metabolite of sulfur mustard formed by simple hydrolysis. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: /SRP: Chemical Weapons Convention/ schedule 2B precursor to mustard gas, sesquimustard, HT, T, and Q. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... The chemical thiodiglycol is used to manufacture ball-point pen ink and is also a precursor for mustard gas. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: As an ingredient in printer ink cartridges. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for THIODIGLYCOL

INCI name

THIODIGLYCOL

INN name

thidiglycol

Description

Thiodiglycol

Record provenance

Inventory reference
38583
Imported identity
THIODIGLYCOL
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
111-48-8
EC
203-874-3
Restriction
—
Function
ANTIOXIDANT
Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28759 · THIODIGLYCOL

Ingredients with overlapping formulation functions

THIOCTOYL PENTAPEPTIDE-4ANTIOXIDANT, BLEACHING, HAIR CONDITIONING, SKIN PROTECTING
THIOCTOYL TETRAPEPTIDE-3ANTIOXIDANT
THIOCTOYL TRIPEPTIDE-1ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING
THIOCTOYL TRIPEPTIDE-35ANTIOXIDANT, BLEACHING, HAIR CONDITIONING, SKIN PROTECTING
THIODIGLYCOLAMIDEANTIOXIDANT, HAIR CONDITIONING
THIODIGLYCOLIC ACIDANTIOXIDANT, REDUCING
THIOGLYCOLIC ACIDANTIOXIDANT, DEPILATORY, HAIR WAVING OR STRAIGHTENING, REDUCING
THIOHISTIDINEANTIOXIDANT, BLEACHING, CHELATING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How THIODIGLYCOL appears in the CosIng inventory

The CosIng inventory lists THIODIGLYCOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

THIODIGLYCOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

THIODIGLYCOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, THIODIGLYCOL carries the following function designation(s):

CAS 111-48-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for THIODIGLYCOL

This page reproduces the CosIng inventory entry for THIODIGLYCOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research THIODIGLYCOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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