What does the restriction note for TEA-SALICYLATE mean?

The restriction field for TEA-SALICYLATE reads: V/3. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 2174-16-5?

CAS 2174-16-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TEA-SALICYLATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3853211/08/2020

TEA-SALICYLATE

Salicylic acid, compound with 2,2',2''-nitrilotriethanol (1:1)

TEA-SALICYLATE is linked to 2 EU annex records on this page. Inventory note: V/3.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	2	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Permitted list with conditions Open this evidence	2	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Restricted Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 2174-16-5

CAS 2174-16-5PubChem CID 25213

Trolamine Salicylate

Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability. It also displays low systemic absorption upon dermal or topical administration and has low skin irritant properties. As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform. Trolamine salicylate serves as an active ingredient in topical over-the-counter products for temporary management of mild to moderate muscular and joint pains. — DrugBank

IUPAC name: 2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic acid

Molecular formula: C13H21NO6
Molecular weight: 287.31 g/mol
Exact mass: 287.13688739 Da
Topological polar surface area: 121.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 7
Covalent units: 2
Defined stereocentres: 0

Also known as

Triethanolamine salicylateTEA-SalicylateTEA salicylateNeo heliopan tsNeotan wArthricreamH8O4040BHDTrolamine salicylate (USP)

16 more reported names

Trolamine salicylate [USP]CannaflexHempvanaArthritis CreamArthritis LeaderArthritis ReliefAsper-FlexAsper-Flex CreamTrolamin SalicylateArthritis with AloeHempvana Pain ReliefArthricream with AloeDCH Arthritis ReliefXCEPTOL PAINCopperlife Pain ReliefCBD Pain Relief Cream

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL2107288
EPA DTXSID:DTXSID4047969
PubMed:24312851
PubMed:19078236
PubMed:18796932
PubMed:8876850

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TEA-SALICYLATE

INCI name

TEA-SALICYLATE

INN name

Trolamine salicylate

Description

Salicylic acid, compound with 2,2',2''-nitrilotriethanol (1:1)

Record provenance

Inventory reference: 38532
Imported identity: TEA-SALICYLATE
Source update: 11/08/2020

European Commission CosIng source notes

Annex records for TEA-SALICYLATE

Annex III Identified ingredient

Entry 62

Trialkylamines, trialkanolamines and their salts

Annex V Restriction reference

Entry 3

SALICYLIC ACID, CALCIUM SALICYLATE, MAGNESIUM SALICYLATE, MEA- SALICYLATE, SODIUM SALICYLATE, POTAS…

CAS: 69-72-7[1]/ 824-35-1[2]/ 18917-89-0[3]/ 59866-70-5[4]/ 54-21-7[5]/ 578-36-9[6]/ 2174-16-5[7]

EC: 200-712-3[1]/ 212-525-4[2]/ 242-669-3[3]/ 261-963-2[4]/ 200-198-0[5]/ 209-421-6[6]/ 218-531-3[7]

Key data

CAS

2174-16-5

218-531-3

Restriction

V/3

Function

LIGHT STABILIZER: Protecting the cosmetic product from deterioration effects of light.
PRESERVATIVE: Exclusively or mainly intended to inhibit the development of micro-organisms in the cosmetic product. All authorised preservatives are substances in the positive list of Annex V to the Cosmetics Regulation 1223/2009.
UV FILTER: Exclusively or mainly intended to protect the skin and/or hair against certain UV radiation by absorbing, reflecting or scattering UV radiation. All authorised UV filters are substances in the positive list of Annex VI to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28450 · TEA-SALICYLATE

The 3 markets that hold a rule for this substance do not classify it the same way.

restricted: European Union South Korea
permitted on a positive list: New Zealand

See every substance the markets disagree about

Ingredients with overlapping formulation functions

SODIUM PHENYLBENZIMIDAZOLE SULFONATEUV ABSORBER, UV FILTER

SR-HYDROZOAN POLYPEPTIDE-1FILM FORMING, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, UV FILTER

STREPTOMYCES SP. AN120535 FERMENT EXTRACT FILTRATEUV FILTER

TEA-PHENYLBENZIMIDAZOLE SULFONATEUV ABSORBER, UV FILTER

TEREPHTHALYLIDENE DICAMPHOR SULFONIC ACIDLIGHT STABILIZER, UV ABSORBER, UV FILTER

TITANIUM DIOXIDECOLORANT, OPACIFYING, UV ABSORBER, UV FILTER

TRIETHOXYSILYLPROPYLIMINOMETHYL METHOXYPHENYLBENZOATESKIN PROTECTING; LIGHT STABILIZER; UV FILTER

TRIS-BIPHENYL TRIAZINELIGHT STABILIZER, UV ABSORBER, UV FILTER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TEA-SALICYLATE appears in the CosIng inventory

The CosIng inventory lists TEA-SALICYLATE as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TEA-SALICYLATE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TEA-SALICYLATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for TEA-SALICYLATE reads: "V/3". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, TEA-SALICYLATE carries the following function designation(s):

CAS 2174-16-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TEA-SALICYLATE

This page combines the CosIng inventory entry for TEA-SALICYLATE with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research TEA-SALICYLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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