
Trolamine Salicylate
Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability. It also displays low systemic absorption upon dermal or topical administration and has low skin irritant properties. As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform. Trolamine salicylate serves as an active ingredient in topical over-the-counter products for temporary management of mild to moderate muscular and joint pains. — DrugBank
- IUPAC name
- 2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic acid
- Molecular formula
- C13H21NO6
- Molecular weight
- 287.31 g/mol
- Exact mass
- 287.13688739 Da
- Topological polar surface area
- 121.0 Ų
- Hydrogen-bond donors
- 5
- Hydrogen-bond acceptors
- 7
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL2107288
- EPA DTXSID:DTXSID4047969
- PubMed:24312851
- PubMed:19078236
- PubMed:18796932
- PubMed:8876850
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.