What does the restriction note for PIGMENT RED 48 mean?

The restriction field for PIGMENT RED 48 reads: II/1348 (Pigment Red 48; CI 15865: when used as a substance in hair dye products). This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 3564-21-4?

CAS 3564-21-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PIGMENT RED 48?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3656913/08/2020

PIGMENT RED 48

Disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate (CI 15865)

PIGMENT RED 48 is linked to 2 EU annex records on this page. Inventory note: II/1348 (Pigment Red 48; CI 15865: when used as a substance in hair dye products).

INCI Checker Compare all markets Search similar

Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

Compare markets

Swipe or scroll horizontally to see every column.

Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	2	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Prohibited + Permitted list with conditions Open this evidence	2	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 3564-21-4

CAS 3564-21-4PubChem CID 135544134

2-naphthalenecarboxylic acid, 4-((5-chloro-4-methyl-2-sulfophenyl)azo)-3-hydroxy-, disodium salt

IUPAC name: disodium;2-[(3-carboxy-2-oxidonaphthalen-1-yl)diazenyl]-4-chloro-5-methylbenzenesulfonate

Molecular formula: C18H11ClN2Na2O6S
Molecular weight: 464.8 g/mol
Exact mass: 463.9821735 Da
Topological polar surface area: 151.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 8
Covalent units: 3
Defined stereocentres: 0

Also known as

07XHK4SAV6CARMINE LAKE 2ACOGILOR RED 313.00RED NO. 405EINECS 240-150-6disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate2-Naphthalenecarboxylic acid, 4-(2-(5-chloro-4-methyl-2-sulfophenyl)diazenyl)-3-hydroxy-, sodium salt (1:2)Disodium 4-((5-chloro-4-methyl-2-sulphonatophenyl)azo)-3-hydroxy-2-naphthoate

11 more reported names

2-Naphthalenecarboxylic acid, 4-[(5-chloro-4-methyl-2-sulfophenyl)azo]-3-hydroxy-, disodium salt2-Naphthalenecarboxylic acid, 4-[2-(5-chloro-4-methyl-2-sulfophenyl)diazenyl]-3-hydroxy-, sodium salt (1:2)RefChem:4766342-Naphthalenecarboxylic acid, 4-(5-chloro-4-methyl-2-sulfophenyl)azo-3-hydroxy-, disodium saltCI 15865UNII-07XHK4SAV6EINECS 222-642-2OMOWMFXCYOTSIM-LDDZECERSA-LPigment red 48 (C.I. 15865)4-((5-Chloro-4-methyl-2-sulfophenyl)azo)-3-hydroxy-2-naphthalenec- arboxylic acid, disodium saltDisodium 2-[(3-carboxy-2-oxidonaphthalen-1-yl)diazenyl]-4-chloro-5-methylbenzene-1-sulfonate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID5063075

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PIGMENT RED 48

INCI name

PIGMENT RED 48

Description

Disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate (CI 15865)

Record provenance

Inventory reference: 36569
Imported identity: PIGMENT RED 48
Source update: 13/08/2020

European Commission CosIng source notes

Annex records for PIGMENT RED 48

Annex II Restriction reference

Entry 1348

Disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate (Pigment Red 48; CI 1…

CAS: 3564-21-4

EC: 222-642-2

Annex IV Identified ingredient

Entry 28

CI 15865

CAS: 3564-21-4; 5280-66-0

EC: 222-642-2

Key data

CAS

3564-21-4

222-642-2

Restriction

II/1348 (Pigment Red 48; CI 15865: when used as a substance in hair dye products)

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#21027 · PIGMENT RED 48

Ingredients with overlapping formulation functions

PIGMENT RED 112HAIR DYEING

PIGMENT RED 172 ALUMINUM LAKECOLORANT, HAIR DYEING

PIGMENT RED 190HAIR DYEING

PIGMENT RED 4HAIR DYEING

PIGMENT RED 5HAIR DYEING

PIGMENT RED 57:1COLORANT, HAIR DYEING

PIGMENT RED 63:1HAIR DYEING

PIGMENT RED 83COLORANT, HAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PIGMENT RED 48 appears in the CosIng inventory

The CosIng inventory lists PIGMENT RED 48 as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PIGMENT RED 48 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PIGMENT RED 48 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for PIGMENT RED 48 reads: "II/1348 (Pigment Red 48; CI 15865: when used as a substance in hair dye products)". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, PIGMENT RED 48 carries the following function designation(s):

HAIR DYEING

CAS 3564-21-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for PIGMENT RED 48

This page combines the CosIng inventory entry for PIGMENT RED 48 with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research PIGMENT RED 48 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect PIGMENT RED 48 and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to PIGMENT RED 48, its identifiers or nearby name variants.