Why does CAS 3564-21-4 appear in more than one EU cosmetic annex?

A substance identified by CAS 3564-21-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 3564-21-4 to screen it directly, then review every linked annex record and supplier document.

CAS 2 records

CAS 3564-21-4

Q: How do I use CAS 3564-21-4 for compliance screening?

Cross-reference CAS 3564-21-4 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 3564-21-4 matches 2 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 3564-21-4

CAS 3564-21-4PubChem CID 135544134

2-naphthalenecarboxylic acid, 4-((5-chloro-4-methyl-2-sulfophenyl)azo)-3-hydroxy-, disodium salt

IUPAC name: disodium;2-[(3-carboxy-2-oxidonaphthalen-1-yl)diazenyl]-4-chloro-5-methylbenzenesulfonate

Molecular formula: C18H11ClN2Na2O6S
Molecular weight: 464.8 g/mol
Exact mass: 463.9821735 Da
Topological polar surface area: 151.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 8
Covalent units: 3
Defined stereocentres: 0

Also known as

07XHK4SAV6CARMINE LAKE 2ACOGILOR RED 313.00RED NO. 405EINECS 240-150-6disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate2-Naphthalenecarboxylic acid, 4-(2-(5-chloro-4-methyl-2-sulfophenyl)diazenyl)-3-hydroxy-, sodium salt (1:2)Disodium 4-((5-chloro-4-methyl-2-sulphonatophenyl)azo)-3-hydroxy-2-naphthoate

11 more reported names

2-Naphthalenecarboxylic acid, 4-[(5-chloro-4-methyl-2-sulfophenyl)azo]-3-hydroxy-, disodium salt2-Naphthalenecarboxylic acid, 4-[2-(5-chloro-4-methyl-2-sulfophenyl)diazenyl]-3-hydroxy-, sodium salt (1:2)RefChem:4766342-Naphthalenecarboxylic acid, 4-(5-chloro-4-methyl-2-sulfophenyl)azo-3-hydroxy-, disodium saltCI 15865UNII-07XHK4SAV6EINECS 222-642-2OMOWMFXCYOTSIM-LDDZECERSA-LPigment red 48 (C.I. 15865)4-((5-Chloro-4-methyl-2-sulfophenyl)azo)-3-hydroxy-2-naphthalenec- arboxylic acid, disodium saltDisodium 2-[(3-carboxy-2-oxidonaphthalen-1-yl)diazenyl]-4-chloro-5-methylbenzene-1-sulfonate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID5063075

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 3564-21-4

2 total

Annex

Entry

1348

Disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate (Pigment Red 48; CI 15865) when used as a substance in hair dye products

222-642-2

How CAS 3564-21-4 is used on this site

CAS 3564-21-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 2 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 3564-21-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 3564-21-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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