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InventoryRef 3587115/10/2010

P-CHLOROPHENOL

4-Chlorophenol

P-CHLOROPHENOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 106-48-9
CAS 106-48-9PubChem CID 4684

4-Chlorophenol

4-chlorophenol is a monochlorophenol substituted at the pare position by a chlorine atom. — ChEBI

IUPAC name
4-chlorophenol
Molecular formula
C6H5ClO
Molecular weight
128.55 g/mol
Exact mass
128.0028925 Da
XLogP3
2.4
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

p-ChlorophenolparachlorophenolPhenol, 4-chloro-4-HydroxychlorobenzenePhenol, p-chloro-4-ChlorphenolApplied 3-784-Monochlorophenol
16 more reported names
p-Chlorophenic acidp-Chlorfenol4-Chloro-1-hydroxybenzeneNSC-28773DLC36A01XCHEBI:28078NSC2877para-monochlorophenolRefChem:522013203-402-6p-Chlorfenol [Czech]4-chloro-phenolNSC 2877Parachlorophenol (JAN/USP)p-Chlorophenol, liquid [UN2021] [Keep away from food]p-Chlorophenol, solid [UN2020] [Keep away from food]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:28078

4-chlorophenol

A monochlorophenol substituted at the pare position by a chlorine atom.

Formula
C6H5ClO
Average mass
128.558 g/mol
Monoisotopic mass
128.00289 Da
Formal charge
0
  • monochlorophenol — is a (CHEBI:38857)
  • monochlorophenol — is a (CHEBI:38857)
Additional curated names
4-chlorophenol4-Chlorophenol4-chlorphenolp-chlorophenolNSC-2877parachlorophenolParachlorophenolp-Chlorophenol
Cross-references from this source
  • CAS: 106-48-9 — KEGG COMPOUND
  • CAS: 106-48-9 — ChemIDplus
  • CAS: 106-48-9 — NIST Chemistry WebBook
  • REGISTRY_NUMBER: 2902 — Gmelin
  • REGISTRY_NUMBER: 507004 — Reaxys
  • MANUAL_X_REF: 4CH — PDBeChem
  • MANUAL_X_REF: C02124 — KEGG COMPOUND
  • MANUAL_X_REF: c0295 — UM-BBD
  • MANUAL_X_REF: CPD-10870 — MetaCyc
  • MANUAL_X_REF: D00149 — KEGG DRUG
  • MANUAL_X_REF: LSM-2913 — LINCS

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2024-06-18. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match4684

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, P391, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H290 (38.9%): May be corrosive to metals [Warning Corrosive to Metals]; H301 (59.7%): Toxic if swallowed [Danger Acute toxicity, oral]; H302 (40.6%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (97.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (59.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (59.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (99.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H411 (99.6%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P234, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P390, P391, P405, P406, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 283 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: 4-chlorophenol is corrosive to epithelial tissue. It produce effects ranging from slight hyperemia to severe corrosion when applied to the corneas. Acute inhalation exposure may lead to hemorrhage in the lungs and tachypnea. Oral exposure to 2-chlorophenol can produce a variety of neurological effects, including tremors, myoclonic convulsions, a hunched posture, dyspnea, collapse, and coma (L159). Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: 4-chlorophenol works as a weak uncoupler of oxidative phosphorylation and inhibitors of cellular respiration. The ability of chlorophenols to uncouple oxidative phosphorylation increases with increasing chlorination. In fact, studies indicate a concentration-dependent triphasic effect of chlorophenols on phosphorylation and cellular respiration. At low concentrations, uncoupling produces stimulation of the resting state respiration as a result of increased adenosine triphosphatase (ATPase) activity in the absence of a phosphate acceptor.Inhibition of active respiration is also observed. At moderate concentrations, resting respiration is neither stimulated nor inhibited. Significant inhibition of respiration, associated with a breakdown of the electron transport process and decreased ATPase activity, occurs at very high concentrations. Uncoupling activity has been attributed to a protonophoric effect (a disruption of the energy gradient across the mitochondrial membrane resulting from distribution of chlorophenols in the phospholipid bilayer of the membrane), whereas inhibition of cellular respiration has been attributed to a direct action on intracellular proteins (L159). Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCFs of 6.0 to 18 for a test concn of 40 ppb and BCFs of 11 to 52 for test concn of 4 ppb was determined for 4-chlorophenol in carp and 42 days exposure(1). The BCF of 4-chlorophenol in goldfish ranged from 10 to 15(2,3). According to a classification scheme(4), these BCF's suggest the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an experimental Koc value range of 70 to 485.6(2-4), indicates that 4-chlorophenol is expected to have high to moderate mobility in soil(SRC). The pKa of 4-chlorophenol is 9.41(5), indicating that this compound will partially exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). Volatilization of 4-chlorophenol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.3X10-7 atm-cu m/mole for the neutral species(SRC) derived from its vapor pressure, 8.90X10-2 mm Hg(7), and water solubility, 2.40X10+4 mg/L(8). 4-Chlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.2X10-2 mm Hg(7). 4-Chlorophenol reached 2% of its theoretical BOD using activated sludge in the Japanese MITI test(9) while complete degradation was reported within 3 days in acclimated sludges(10,11). 4-Chlorophenol degraded in clay and silt loams soils from 84-100% in 3-16 days(12-14) and 22.2% and 35% in 1 and 10 weeks, respectively, in Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an experimental Koc value range of 70 to 485.6(2-4), indicates that 4-chlorophenol may exhibit low to moderate absorption to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(5) based upon an estimated Henry's Law constant of 6.3X10-7 atm-cu m/mole for the neutral species(SRC) derived from its vapor pressure, 8.90X10-2 mm Hg(6), and water solubility, 2.40X10+4 mg/L(7). According to a classification scheme(8), a BCF range of 6.0-18(6,9, 10) suggests the potential for bioconcentration in aquatic organisms is low(SRC). 4-Chlorophenol undergoes flash-induced aquatic photolysis in both aerated and non-aerated solns(11) and photolytic oxidation by UV/ozone(12). Biodegradation of 4-chlorophenol in water varies depending on the conditions. Complete removals have been reported in water after 13 days for acclimated water(13) and 30 days in farm stream sediment(14), 44% degradation after 5 days(15) and 33% after 25 days in non-acclimated water(13). These data suggest that biodegradation will vary depending on the conditions(SRC). Since the pKa of 4-chlorophenol is 9.41(16), it will exist in water and sedim Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4-chlorophenol, which has a vapor pressure of 8.90X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 4-chlorophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.3 days(SRC), calculated from its rate constant of 9.9X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The quantum yield for the disappearance of 4-chlorophenol was 0.25 when it was irradiated at 296 nm in aqueous solution at pH 1-13; products of photolysis included hydroquinone(4). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as a chemical intermediate for pesticides, dyestuffs, and pharmaceuticals; Also used as a denaturant for alcohol, selective solvent in refining mineral oils, antiseptic, soil sterilant, adhesion promoting agent, and local antibacterial agent in root canal therapy; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Working with Glues and Adhesives [Category: Other]; Using Disinfectants or Biocides [Category: Clean]; Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: CHEM INT FOR THE ACARICIDE, OVEX, RODENTICIDE, PHOSACETIN, PHARMACEUTICALS; DENATURANT FOR ALCOHOL; SELECTIVE SOLVENT IN REFINING MINERAL OILS Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Intermediate in synthesis of dyes and drugs; denaturant for alcohol; selective solvent in refining mineral oil Source: Hazardous Substances Data Bank (HSDB)
  • Uses: To produce 2,4-dichlorophenol, and a germicide, 4-chlorophenol-o-cresol. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In the synthesis of derivatives of quinizarin, anthraquinone dyes; in the synthesis of the biocide 2-benzyl-4-chlorophenol; in the synthesis of the fungicides dichlorophen and triadimefon; in the synthesis of the cholesterol-reducing drug ethyl-alpha,alpha-dimethyl-4-chlorophenoxy acetate Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 4-CHLOROPHENOL (11 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Use (kg; approx.) in Germany (2009): >10; Consumption (g per capita; approx.) in Germany (2009): 0.000122; Calculated removal (%): 77 Source: NORMAN Suspect List Exchange
  • Uses: Breathing in contaminated air; drinking contaminated water; dermal and eye exposure (L159). Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for P-CHLOROPHENOL

INCI name

P-CHLOROPHENOL

INN name

parachlorophenol

Description

4-Chlorophenol

Record provenance

Inventory reference
35871
Imported identity
P-CHLOROPHENOL
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
106-48-9
EC
203-402-6
Restriction
—
Function
ANTIMICROBIAL
Preventing and/or slowing down microbial growth.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#19144 · P-CHLOROPHENOL

Ingredients with overlapping formulation functions

OZONIZED PEG-14 OLEATEANTIMICROBIAL, CLEANSING, SURFACTANT - CLEANSING
OZONIZED POLYSORBATE 80ANTIMICROBIAL, CLEANSING, SURFACTANT - CLEANSING
OZONIZED TURPENTINEANTIMICROBIAL, OXIDISING, SKIN CONDITIONING
P-CHLORO-M-CRESOLANTIMICROBIAL, PRESERVATIVE
P-CRESOLANTIMICROBIAL, PERFUMING
PAECILOMYCES JAPONICA/MORUS ALBA LEAF FERMENT FILTRATEANTIMICROBIAL
PAEONIA LACTIFLORA PHYTOPLACENTA EXTRACTANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING
PAEONIA SUFFRUTICOSA CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How P-CHLOROPHENOL appears in the CosIng inventory

The CosIng inventory lists P-CHLOROPHENOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

P-CHLOROPHENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

P-CHLOROPHENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, P-CHLOROPHENOL carries the following function designation(s):

CAS 106-48-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for P-CHLOROPHENOL

This page reproduces the CosIng inventory entry for P-CHLOROPHENOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research P-CHLOROPHENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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