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InventoryRef 3533815/10/2010

METHYLETHANOLAMINE

2-Methylaminoethanol

METHYLETHANOLAMINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 109-83-1
CAS 109-83-1PubChem CID 8016

2-(Methylamino)ethanol

N-methylethanolamine is an ethanolamine compound having an N-methyl substituent. — ChEBI

IUPAC name
2-(methylamino)ethanol
Molecular formula
C3H9NO
Molecular weight
75.11 g/mol
Exact mass
75.068413911 Da
XLogP3
-0.9
Topological polar surface area
32.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

N-Methylethanolamine2-METHYLAMINOETHANOLMethylethanolamineMethylethylolamineEthanol, 2-(methylamino)-N-Methyl-2-aminoethanol2-(N-Methylamino)ethanolN-Methylmonoethanolamine
16 more reported names
MonomethylaminoethanolMonomethylethanolamine(2-Hydroxyethyl)methylamineN-MonomethylaminoethanolMethyl(2-hydroxyethyl)amineMonomethylmonoethanolamineN-Methyl-2-ethanolamine2-Hydroxy-N-methylethylamineN-Methyl-2-hydroxyethylamineUsaf do-50N-(2-Hydroxyethyl)methylamineMonomethyl-aminoaethanolAmietol M 112-N-Monomethylaminoethanolbeta-(Methylamino)ethanolMethyl(beta-hydroxyethyl)amine
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8016

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (> 99.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (21.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335 (23.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 3117 reports by companies from 26 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P260, P264, P264+P265, P270, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P362+P364, P363, P370+P378, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 2-Methylaminoethanol is a viscous liquid. It is used in the manufacture of textile chemicals, pharmaceuticals. HUMAN EXPOSURE AND TOXICITY: Prolonged hematuria, pathologic liver function tests, and multiple skin warts described in a patient after 2-methylaminoethanol exposure. ANIMAL STUDIES: In rats it was irritating to the skin, eyes, and mucous membranes. 2-Methylaminoethanol (150 ppm) was not maternally toxic or embryotoxic in rats. It was not mutagenic in S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 with and without metabolic activation. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 2-methylaminoethanol(SRC), using a log Kow of -0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-methylaminoethanol is expected to have very high mobility in soil(SRC). The pKa of 2-methylaminoethanol is 9.95(3), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the neutral species of 2-methylaminoethanol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.1X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 2-Methylaminoethanol is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.08 mm Hg at 25 °C(5). A 68% of theoretical BOD using activated sludge in the Japanese MITI test classifies 2-methylaminoethanol as readily biodegradable(6) and suggests that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-methylaminoethanol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 8.1X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). The pKa of 2-methylaminoethanol is 9.95(4), indicating that this compound will exist almost entirely in cation form in the environment, and volatilization from water is unlikely since cations do not volatilize(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of -0.94(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 68% of theoretical BOD using activated sludge in the Japanese MITI test classifies 2-methylaminoethanol as readily biodegradable(7) and suggests that biodegradation is an important environmental fate process in water(SRC). Hydrolysis is not expected to be an important environmental fate process(SRC) since this compound lacks functional grou Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-methylaminoethanol, which has a vapor pressure of 1.08 mm Hg at 25 °C (2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-methylaminoethanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.9 hours(SRC), calculated from its rate constant of 7.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Methylaminoethanol does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight(4). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for METHYLETHANOLAMINE

INCI name

METHYLETHANOLAMINE

Description

2-Methylaminoethanol

Record provenance

Inventory reference
35338
Imported identity
METHYLETHANOLAMINE
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
109-83-1
EC
203-710-0
Restriction
—
Function
BUFFERING
Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16628 · METHYLETHANOLAMINE

Ingredients with overlapping formulation functions

METAPHOSPHORIC ACIDBUFFERING, CHELATING
METHOXY PEG-100/POLYEPSILON CAPROLACTONE ETHYLHEXANOATEBUFFERING, FILM FORMING, HAIR CONDITIONING, HAIR FIXING
METHOXY PEG-100/POLYEPSILON CAPROLACTONE PALMITATEBUFFERING, FILM FORMING, HAIR CONDITIONING, HAIR FIXING
METHOXY PEG-114/POLYEPSILON CAPROLACTONEBUFFERING, FILM FORMING, HAIR CONDITIONING
MIPA-BORATEBUFFERING
MIXED ISOPROPANOLAMINESBUFFERING
MONOSODIUM CITRATEBUFFERING
MORPHOLINEBUFFERING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How METHYLETHANOLAMINE appears in the CosIng inventory

The CosIng inventory lists METHYLETHANOLAMINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

METHYLETHANOLAMINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

METHYLETHANOLAMINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, METHYLETHANOLAMINE carries the following function designation(s):

CAS 109-83-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for METHYLETHANOLAMINE

This page reproduces the CosIng inventory entry for METHYLETHANOLAMINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research METHYLETHANOLAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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