Is HIPPURIC ACID safe to use in EU cosmetics?

HIPPURIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 495-69-2?

CAS 495-69-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3429515/10/2010

HIPPURIC ACID

Glycine, N-benzoyl-

HIPPURIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 495-69-2

CAS 495-69-2PubChem CID 464

Hippuric Acid

N-benzoylglycine is an N-acylglycine in which the acyl group is specified as benzoyl. It has a role as a uremic toxin and a human blood serum metabolite. It is a conjugate acid of a N-benzoylglycinate. — ChEBI

IUPAC name: 2-benzamidoacetic acid

Molecular formula: C9H9NO3
Molecular weight: 179.17 g/mol
Exact mass: 179.058243149 Da
XLogP3: 0.3
Topological polar surface area: 66.4 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

N-BenzoylglycineBenzoylglycineGlycine, N-benzoyl-Benzamidoacetic acidBenzoylaminoacetic acidhippurateHippursaeure2-(Phenylformamido)Acetic Acid

16 more reported names

Phenylcarbonylaminoacetic acidBenzamidoessigsaeureBenzoylaminoessigsaeureAcido ippuricoTE0865N2ETHIPPURICUM ACIDUMNSC-9982CHEBI:18089RefChem:5887CHEBI:132966207-806-3(benzoylamino)acetic acidBz-Gly-OHN-Benzoyl-glycinAcetic acid, (benzoylamino)-Acido ippurico [Italian]

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:18089
ChEMBL:CHEMBL461
EPA DTXSID:DTXSID9046073
PubMed:29968805
PubMed:23095112
PubMed:23076896
PubMed:23076891
PubMed:23043709
PubMed:23030327
PubMed:23022855
PubMed:23022850
PubMed:22953206
PubMed:22932811
PubMed:22932763
PubMed:22914820

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HIPPURIC ACID

INCI name

HIPPURIC ACID

Description

Glycine, N-benzoyl-

Record provenance

Inventory reference: 34295
Imported identity: HIPPURIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for HIPPURIC ACID

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Key data

CAS

495-69-2

207-806-3

Restriction

—

Function

HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#12090 · HIPPURIC ACID

Ingredients with overlapping formulation functions

HIBISCUS SCANDENS FLOWER EXTRACTANTI-SEBUM; SKIN CONDITIONING - EMOLLIENT; HAIR CONDITIONING

HIBISCUS SYRIACUS CALLUS CULTURE EXTRACTANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

HINOKITIOLANTISTATIC, HAIR CONDITIONING

HIPPOPHAE RHAMNOIDES CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

HISTIDINE HCLHAIR CONDITIONING, SKIN CONDITIONING

HONEY POWDERABRASIVE, BINDING, BULKING, FLAVOURING, HAIR CONDITIONING, NAIL CONDITIONING, SKIN CONDITIONING

HORSE ADIPOSE STROMAL CELL CONDITIONED MEDIAHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

HOUTTUYNIA CORDATA LEAF EXTRACTANTIOXIDANT; ANTI-SEBUM; SKIN CONDITIONING - EMOLLIENT; HAIR CONDITIONING; HUMECTANT; SKIN PROTECTI…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HIPPURIC ACID appears in the CosIng inventory

The CosIng inventory lists HIPPURIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HIPPURIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HIPPURIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HIPPURIC ACID carries the following function designation(s):

HAIR CONDITIONING

CAS 495-69-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HIPPURIC ACID

This page reproduces the CosIng inventory entry for HIPPURIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HIPPURIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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