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InventoryRef 3428315/10/2010

HEXYLENE GLYCOL

2-Methylpentane-2,4-diol

HEXYLENE GLYCOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 107-41-5
CAS 107-41-5PubChem CID 7870

Hexylene Glycol

2-methylpentane-2,4-diol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane). — ChEBI

IUPAC name
2-methylpentane-2,4-diol
Molecular formula
C6H14O2
Molecular weight
118.17 g/mol
Exact mass
118.099379685 Da
XLogP3
0.3
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

2-METHYL-2,4-PENTANEDIOLPinakonDiolane2,4-Dihydroxy-2-methylpentaneIsol2,4-Pentanediol, 2-methyl-1,1,3-Trimethyltrimethylenediol4-Methyl-2,4-pentanediol
16 more reported names
2-Methyl pentane-2,4-diol2-Methyl-2,4-pentandiolNSC-8098KEH0A3F75Jalpha,alpha,alpha'-Trimethyltrimethylene glycol1,3-dimethyl-3-hydroxybutanol1,3,3-trimethyl-1,3-propanediolCHEBI:62995RefChem:5886203-489-0TRACID RUBINE 5BLHexylene glycol [NF]Hexylene glycol (NF)NSC 8098MPDCaswell No. 574
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:62995

2-methylpentane-2,4-diol

A glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).

Formula
C6H14O2
Average mass
118.176 g/mol
Monoisotopic mass
118.09938 Da
Formal charge
0
  • glycol — is a (CHEBI:13643)
  • glycol — is a (CHEBI:13643)
Additional curated names
2-methylpentane-2,4-diol1,1,3-trimethyl-1,3-propanediol1,1,3-Trimethyltrimethylenediol1,3,3-trimethyl-1,3-propanediol1,3-dimethyl-3-hydroxybutanol2,4-Dihydroxy-2-methylpentane2-Methyl-2,4-pentandiol2-Methyl-2,4-pentanediol2-Methyl pentane-2,4-diol4-Methyl-2,4-pentanediolHexylene glycolMPDalpha,alpha,alpha'-trimethyltrimethylene glycol
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-04-17. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7870

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Excerpt from NIOSH Pocket Guide for Hexylene glycol:; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: WATER WASH IMMEDIATELY - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.; Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.; Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 5235) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (97.4%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (99.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 5235 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 5235 reports by companies.; There are 15 notifications provided by 5234 of 5235 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P280, P370+P378, P403, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Hexylene glycol is a colorless liquid used as a chemical intermediate, a selective solvent in petroleum refining, a component of hydraulic fluids, a solvent for inks, a cement additive, and in cosmetics. HUMAN EXPOSURE AND TOXICITY: Five human subjects given oral doses of 37 g of hexylene glycol daily for 24 days (estimated daily dosage 14-28 mg/kg body weight) reported no subjective symptoms that could be attributed to the intake of hexylene glycol; no alterations in urine parameters were detected. In another study, most subjects exposed for 15 min to 50 ppm of hexylene glycol in the air were able to detect the odor and a few noted eye irritation. At a concentration of 100 ppm, the odor was plain and some noted nasal irritation and respiratory discomfort. At 1000 ppm (4840 mg/cu m), there was irritation of the eyes, nose, and throat, and respiratory discomfort. Additionally, a case of severe contact urticaria with systemic involvement resembling an anaphylactic reaction, following the application of a topical corticosteroid formulated with hexylene glycol as an excipient has been reported. Swelling and redness were seen in 23 out of 823 eczema patients who Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 2-methyl-2,4-pentanediol(SRC), using an estimated log Kow of 0.58(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-methyl-2,4-pentanediol is expected to have very high mobility in soil(SRC). Volatilization of 2-methyl-2,4-pentanediol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.1X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(3). 2-Methyl-2,4-pentanediol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.0X10-2 mm Hg at 25 °C(4). Utilizing the Japanese MITI test, 55.7% of the Theoretical BOD was reached in 2 weeks(5) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-methyl-2,4-pentanediol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.1X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of 0.58(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 55.7% of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-methyl-2,4-pentanediol, which has a vapor pressure of 7.0X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-methyl-2,4-pentanediol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 hrs(SRC), calculated from its rate constant of 2.77X10-11 cu cm/molecule-sec at 25 °C(3). 2-Methyl-2,4-pentanediol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Etching agent; Chelating agent; Intermediate; Filler; Not Known or Reasonably Ascertainable; Hydraulic fluids; Cleaning agent; Plating agent; Processing aids not otherwise specified; Tanning agents not otherwise specified; Lubricating agent; Solvent; Anti-freeze agent Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HEXYLENE GLYCOL

INCI name

HEXYLENE GLYCOL

INN name

hexylene glycol

Description

2-Methylpentane-2,4-diol

Record provenance

Inventory reference
34283
Imported identity
HEXYLENE GLYCOL
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
107-41-5
EC
203-489-0
Restriction
—
Function
PERFUMING
Used for perfume and aromatic raw materials.
SKIN CONDITIONING
Maintaining the skin in good condition.
SOLVENT
Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).
SURFACTANT - CLEANSING
Wetting body surfaces, emulsifying or solubilizing oils, and suspending soil (generally, such ingredients contribute to the foaming and lathering properties of cleansing products).
SURFACTANT - EMULSIFYING
Helping suspensions or dispersions of liquids in a second liquid by reducing the surface tension of the substances to be emulsified.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11992 · HEXYLENE GLYCOL

Ingredients with overlapping formulation functions

HEXETH-5CLEANSING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING, SURFACTANT - HYDROTROPE
HEXYL ALCOHOLANTIFOAMING, PERFUMING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - HYDROTROPE
HEXYLDECYL BENZOATEPLASTICISER, SKIN CONDITIONING - EMOLLIENT, SOLVENT
HEXYLDODECYL SALICYLATEHAIR CONDITIONING, SKIN CONDITIONING, SOLVENT
HEXYLOXYETHANOLSOLVENT
HIPPOPHAE RHAMNOIDES FRUIT WATERSOLVENT
HUMAN BONE MARROW STEM CELL CONDITIONED MEDIA EXTRACTBLEACHING, HUMECTANT, ORAL CARE, SKIN CONDITIONING, SKIN PROTECTING, SOLVENT
HUMAN UMBILICAL MESENCHYMAL STEM CELL CONDITIONED MEDIA EXTRACTANTIOXIDANT, HUMECTANT, SKIN PROTECTING, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How HEXYLENE GLYCOL appears in the CosIng inventory

The CosIng inventory lists HEXYLENE GLYCOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HEXYLENE GLYCOL is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HEXYLENE GLYCOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HEXYLENE GLYCOL carries the following function designation(s):

CAS 107-41-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for HEXYLENE GLYCOL

This page reproduces the CosIng inventory entry for HEXYLENE GLYCOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HEXYLENE GLYCOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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