What does the restriction note for GLYCERYL THIOGLYCOLATE mean?

The restriction field for GLYCERYL THIOGLYCOLATE reads: III/2b. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 30618-84-9?

CAS 30618-84-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains GLYCERYL THIOGLYCOLATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3411215/10/2010

GLYCERYL THIOGLYCOLATE

Mercaptoacetic acid, monoester with propane-1,2,3-triol

GLYCERYL THIOGLYCOLATE is linked to 1 EU annex record on this page. Inventory note: III/2b.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 30618-84-9

CAS 30618-84-9PubChem CID 3034372

Glyceryl monothioglycolate

Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol. As a component of developer solutions in permanent wave products, it is the second most frequent allergen in hairdressers and avoidance of acid permanent waves is mandatory. It has a role as an allergen. — ChEBI

IUPAC name: 2,3-dihydroxypropyl 2-sulfanylacetate

Molecular formula: C5H10O4S
Molecular weight: 166.20 g/mol
Exact mass: 166.02997997 Da
XLogP3: -0.7
Topological polar surface area: 67.8 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

Glycerol monomercaptoacetateAcetic acid, 2-mercapto-, monoester with 1,2,3-propanetriolCHEBI:1565450FWE72AF2PMercaptoacetic acid, monoester with 1,2,3-propanetriolRefChem:663554250-264-8Glyceryl thioglycolate

16 more reported names

Glyceryl 1-thioglycolateGlyceryl 1-monothioglycolateGlycerol 1-monothioglycolateAcetic acid, mercapto-, monoester with 1,2,3-propanetriol2,3-dihydroxypropyl sulfanylacetateAcetic acid, 2-mercapto-, 2,3-dihydroxypropyl ester0A100Y3J61EINECS 250-264-8UNII-0FWE72AF2PUNII-0A100Y3J61Mercaptoacetic acid, monoester with propane-1,2,3-triolglycerol monothioglycolateGlyceryl monothioglycolate, Technical gradeGlycerolmonomercaptoacetateEC 250-264-8Acetic acid, mercapto-, monoester with glycerol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:156545
EPA DTXSID:DTXSID60873439
PubMed:22238032
PubMed:21997384
PubMed:21461388
PubMed:20565505
PubMed:20525126
PubMed:20386627
PubMed:20187494
PubMed:19999041
PubMed:19636068
PubMed:19134431
PubMed:17976140
PubMed:16842556

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GLYCERYL THIOGLYCOLATE

INCI name

GLYCERYL THIOGLYCOLATE

Description

Mercaptoacetic acid, monoester with propane-1,2,3-triol

Record provenance

Inventory reference: 34112
Imported identity: GLYCERYL THIOGLYCOLATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for GLYCERYL THIOGLYCOLATE

Annex III Restriction reference

Entry 2b

Thioglycolic acid esters

Key data

CAS

30618-84-9

250-264-8

Restriction

III/2b

Function

HAIR WAVING OR STRAIGHTENING: Modifying the chemical structure of the hair, allowing it to be set in the style required (permanent waves or hair straightening).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11232 · GLYCERYL THIOGLYCOLATE

Ingredients with overlapping formulation functions

DITHIOTHREITOLHAIR WAVING OR STRAIGHTENING, REDUCING

ETHANOLAMINE THIOGLYCOLATEDEPILATORY, HAIR WAVING OR STRAIGHTENING, REDUCING

ETHYL THIOGLYCOLATEDEPILATORY, HAIR WAVING OR STRAIGHTENING, REDUCING

ETHYLENEDIAMINO PG-PROPYL PEG-4 DIMETHICONEHAIR CONDITIONING; HAIR DYEING; HAIR FIXING; HAIR WAVING OR STRAIGHTENING

GLYCERYL THIOPROPIONATEHAIR WAVING OR STRAIGHTENING, REDUCING

GLYOXYLIC ACIDANTISTATIC, BUFFERING, HAIR WAVING OR STRAIGHTENING

GLYOXYLOYL CARBOCYSTEINEANTISTATIC, HAIR WAVING OR STRAIGHTENING

GLYOXYLOYL CYSTEINEHAIR WAVING OR STRAIGHTENING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How GLYCERYL THIOGLYCOLATE appears in the CosIng inventory

The CosIng inventory lists GLYCERYL THIOGLYCOLATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GLYCERYL THIOGLYCOLATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GLYCERYL THIOGLYCOLATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for GLYCERYL THIOGLYCOLATE reads: "III/2b". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, GLYCERYL THIOGLYCOLATE carries the following function designation(s):

HAIR WAVING OR STRAIGHTENING

CAS 30618-84-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for GLYCERYL THIOGLYCOLATE

This page combines the CosIng inventory entry for GLYCERYL THIOGLYCOLATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research GLYCERYL THIOGLYCOLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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