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InventoryRef 3309715/10/2010

CYCLOHEXANE

Cyclohexane

CYCLOHEXANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 110-82-7
CAS 110-82-7PubChem CID 8078

Cyclohexane

Cyclohexane is an alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon. It has a role as a non-polar solvent. It is a volatile organic compound and a cycloalkane. — ChEBI

IUPAC name
cyclohexane
Molecular formula
C6H12
Molecular weight
84.16 g/mol
Exact mass
84.093900383 Da
XLogP3
3.4
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

HexamethyleneHexahydrobenzeneHexanaphtheneCyclohexanCykloheksanBenzene, hexahydro-CicloesanoCyclohexaan
16 more reported names
BenzenehexahydrideRCRA waste number U056Caswell No. 269CCRIS 3928EPA Pesticide Chemical Code 025901NSC-40683548K5MKG32SAI3-08222CHEBI:29005Benzene hexahydrideRefChem:6634203-806-2hexahydro-Benzenecyclo-hexaneNSC 406835Acid red 300
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8078

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • ERG2024, Guide 128 (Cyclohexane): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P271, P273, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P319, P321, P331, P332+P317, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 4880) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H304 (> 99.9%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H336 (99.8%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H400 (> 99.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (98.1%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P271, P273, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P319, P321, P331, P332+P317, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 4880 reports by companies from 67 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 4880 reports by companies.; There are 66 notifications provided by 4879 of 4880 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H305: May be harmful if swallowed and enters airways [Warning Aspiration hazard]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: NITE-CMC
  • Health Effects: Petroleum distillates are aspiration hazards and may cause pulmonary damage, central nervous system depression, and cardiac effects such as cardiac arrhythmias. They may also affect the blood, immune system, liver, and kidney. (A600, L1297) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Cyclohexane is a colorless, highly flammable liquid occurring naturally in petroleum at concentrations of 0.5-1.0%. It has a pungent petroleum-like odor and is used as an organic solvent for lacquers, resins, and synthetic rubber; paint and varnish remover; extraction of essential oils; manufacturing of solid fuel for camp stoves; in fungicidal formulations; in recrystallization of steroids; and in analytical chemistry for molecular weight determinations. It is also a chemical intermediate in the manufacturing of adipic acid, benzene, cyclohexyl chloride, nitrocyclohexane, cyclohexanol and cyclohexanone. Not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. Studies from the exposure of the general population to cyclohexane revealed that human milk from five of eight mothers contained cyclohexane (concentrations not determined) from the mothers' exposure to environmental pollutants since they resided near chemical manufacturing plants or industrial user facilities. HUMAN EXPOSURE AND TOXICITY: The available data indica Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Petroleum distillates are central nervous system depressants and cause pulmonary damage. (A600) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: Using carp (Cyprinus carpio) which were exposed over an 8-week period, the BCF of cyclohexane ranged from 31-102 at a concentration of 0.1 mg/L and 37-129 at a concentration of 0.01 mg/L(1). An experimental BCF of 158 has also been reported(2). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is moderate to high, provided the compound is not metabolized by the organism(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a structure estimation method(2), and an estimated Koc of 350, derived from sorption studies in a high-organic soil(3) indicate that cyclohexane is expected to have moderate mobility in soil(SRC). Volatilization of cyclohexane from moist soil surfaces is expected to be important(SRC) given a Henry's Law constant of 0.15 atm-cu m/mole(4). Cyclohexane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 96.9 mm Hg at 25 °C(5). Available biodegradation screening tests have conflicting results concerning the ready biodegradability of cyclohexane(6). Utilizing the Japanese MITI test, only 8% of the Theoretical BOD was reached in 4 weeks indicating not-readily biodegradable(7). In contrast, OECD Method 301F (Manometric Respirometry Test) observed 77% degradation after 28 days(6). Little mineralization of cyclohexane was detected in a single soil biodegradation test(8). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a structure estimation method(2), and an estimated Koc of 350, derived from sorption studies in a high-organic soil(3), indicates that cyclohexane may have moderate adsorption to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 0.15 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 2.7 hours and 3.6 days, respectively(SRC). According to a classification scheme(6), a BCF range of 31-129 measured in carp (Cyprinus carpio)(7), suggests bioconcentration in aquatic organisms is moderate to high(SRC). Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions(4). Available biodegradation screening tests have conflicting results concerning the ready biodegradability of cyclohexane(8). Utilizing the Japanese MITI test, only 8% of the Theoretical BOD was reached in 4 weeks indicating not-readily biodegradable(9). In Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclohexane, which has a vapor pressure of 96.9 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cyclohexane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.3 days(SRC), calculated from its rate constant of 6.97X10-12 cu cm/molecule-sec at 25 °C(3). Cyclohexane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Laboratory studies have suggested that adsorption from the gas-phase in the atmosphere to ambient surfaces may have some importance as an environmental fate process(5). Cyclohexane can contribute to the formation of photochemical smog when it reacts with other volatile organic carbon compounds in the air(6). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Solvent; Processing aids not otherwise specified; Fuel; Fuel agents; Not Known or Reasonably Ascertainable; Catalyst; Drier; Intermediate; Laboratory chemicals Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used in the production of nylon and as a paint and varnish remover; Also used as a solvent (lacquers, resins, and glues, e.g., in leather manufacturing) and intermediate for organic synthesis; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Leather Tanning and Processing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For cyclohexane (USEPA/OPP Pesticide Code: 025901) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Organic solvent for lacquers and resins. Paint and varnish remover. In the extraction of essential oils. In analytical chemistry for molecular weight determinations (cryoscopic constant 20.3). In the manufacturing of adipic acid, benzene, cyclohexyl chloride, nitrocyclohexane, cyclohexanol and cyclohexanone. In the manufacturing of solid fuel for camp stoves. In fungicidal formulations (possesses slight fungicidal action). In the industrial recrystallization of steroids. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Manufacture of nylon; solvent for cellulose ethers, fats, oils, waxes, bitumens, resins, crude rubber; extraction essential oils; organic synthesis; paint and varnish removers; glass substitutes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Over 98% of the cyclohexane produced is used to make nylon intermediates: adipic acid (60%), caprolactam, and hexamethylenediamine 75% of the caprolactam produced worldwide is used for nylon 6 manufacture. Minor miscellaneous uses, such as solvents and polymer reaction diluents, consume the remainder of the cyclohexane produced. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: /SRP: Previously used as an anesthetic. This was discontinued due to the risk of explosion./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Cyclohexane is a component of gasoline and is used as a solvent in the chemical industry, and also as a raw material for the industrial production of adipic acid and caprolactam, both of which are intermediates used in the production of nylon. (L1299) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CYCLOHEXANE

INCI name

CYCLOHEXANE

Description

Cyclohexane

Record provenance

Inventory reference
33097
Imported identity
CYCLOHEXANE
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
110-82-7
EC
203-806-2
Restriction
—
Function
SOLVENT
Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7845 · CYCLOHEXANE

Ingredients with overlapping formulation functions

CRYPTOMERIA JAPONICA BARK EXTRACTDEODORANT, SOLVENT
CUPHEA VISCOSISSIMA SEED OILHAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT
CYCLOETHOXYMETHICONESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT
CYCLOHEPTASILOXANEANTICAKING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT
CYCLOHEXANONEPERFUMING, SOLVENT
CYCLOHEXASILOXANEHAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT
CYCLOHEXYL TOLUATESOLVENT, SURFACTANT - CLEANSING
CYCLOMETHICONEHAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How CYCLOHEXANE appears in the CosIng inventory

The CosIng inventory lists CYCLOHEXANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CYCLOHEXANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CYCLOHEXANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CYCLOHEXANE carries the following function designation(s):

CAS 110-82-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for CYCLOHEXANE

This page reproduces the CosIng inventory entry for CYCLOHEXANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CYCLOHEXANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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