Official EU label nameGlossary entry 9662

DYPHYLLINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:479-18-5

EC:207-526-1

Ingredient index records:

DYPHYLLINE

Cosmetic functions: SKIN CONDITIONING

1,3-Dimethyl-7-(2,3-Dihydroxypropyl) Xanthine; Diprophylline; Theophylline, 7-(2,3-dihydroxypropyl)-

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2 matched or reported names

DYPHYLLINEDyphylline [USAN]

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name DYPHYLLINE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 479-18-5

CAS 479-18-5PubChem CID 3182

Diprophylline

Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs. It has a role as a bronchodilator agent, a vasodilator agent, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and a muscle relaxant. It is an oxopurine and a member of propane-1,2-diols. — ChEBI

IUPAC name: 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione

Molecular formula: C10H14N4O4
Molecular weight: 254.24 g/mol
Exact mass: 254.10150494 Da
XLogP3: -1.8
Topological polar surface area: 98.9 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

dyphylline7-(2,3-Dihydroxypropyl)theophyllineDiphyllineGlyphyllineCorphyllinNeutrafillinaNeutraphyllineNeutroxantina

16 more reported names

ProtheophyllineSynthophyllineGlyfyllinGlyphyllinHyphyllineNeophyllinHidroxiteofillinaAstrophyllinCoronarinHiphyllinNeophyllineNeotilinaNeutrafilPurifilinSilbephyllineSolufilin

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External database identifiers

ChEBI:CHEBI:4728
ChEMBL:CHEMBL1752
EPA DTXSID:DTXSID6022975
PubMed:22662200
PubMed:22321288
PubMed:22245221
PubMed:22113078
PubMed:22008146
PubMed:21515350
PubMed:21042488
PubMed:20638213
PubMed:20026047
PubMed:19778159
PubMed:19755002
PubMed:19737588

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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