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Official EU label nameGlossary entry 9575

DODECANE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:112-40-3
EC:203-967-9
Ingredient index records:
DODECANE
Cosmetic functions: PERFUMING

Dodecane

Open full local profile
1 matched or reported name
DODECANE

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

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MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
No local match0
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada
CA
No local match0
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand
NZ
No local match0
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
ASEAN
ASEAN
No local match0
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
No local match0
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Chemical identity and properties

PubChem 2D chemical structure for CAS 112-40-3
CAS 112-40-3PubChem CID 8182

Dodecane

IUPAC name
dodecane
Molecular formula
C12H26
Molecular weight
170.33 g/mol
Exact mass
170.203450829 Da
XLogP3
6.1
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

n-DodecaneDihexylBihexylAdakane 12N-DodecanDuodecaneBa 51-09045311A386X1QH
16 more reported names
NSC-8714CHEBI:28817RefChem:5775203-967-9dodecanNSC 8714Dodecane(mixture of isomers)Undecane, methyl-n-Dodecan [German]Hydrocarbons, C4,1,3-butadiene-free, polymd., triisobutylene fraction, hydrogenatedD12CCRIS 661HSDB 5133EINECS 203-967-9BRN 1697175Dodekan
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8182

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: If any of your personnel should inhale this substance you should remove them immediately to open air. If symptoms develop, seek medical attention.; INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 0.4% (4 of 1042) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H304 (57.2%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H319 (43.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P280, P301+P316, P305+P351+P338, P331, P337+P317, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1042 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 4 of 1042 reports by companies.; There are 10 notifications provided by 1038 of 1042 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 4.2% (36 of 853) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (95.7%): Flammable liquid and vapor [Warning Flammable liquids]; H304 (95.8%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H410 (12.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H413 (19%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P273, P280, P301+P316, P303+P361+P353, P331, P370+P378, P391, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 853 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 36 of 853 reports by companies.; There are 8 notifications provided by 817 of 853 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P280, P301+P316, P331, P370+P378, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Dodecane is a colorless liquid. Dodecane is a component of gasoline and is used as solvent, in organic synthesis, in jet fuel research, as a distillation chaser, and in the rubber and paper processing industries. HUMAN EXPOSURE AND TOXICITY: Dodecane may be harmful if inhaled, swallowed, or absorbed through the skin. It can be irritating to mucous membranes. ANIMAL STUDIES: Dodecane, can produce slight to severe dermal irritation and respiratory in animals. However, it produced only minimal to negligible ocular irritation. Rats exposed to inhalation to 0.2 mL dodecane died within 24 hours of progressive edema and hemorrhaging. Dodecane did not show any effects, including no central nervous system depression, when rats were exposed at the saturated vapor concentrations. Dodecane, applied topically to progeny of rats treated with benzo(a)pyrene, chrysene, or benzo(b)triphenylene on gestation day 1, produced tumors in offspring. Dodecane has been shown to be a promoter of skin carcinogenesis for ultraviolet radiation. Dodecane, did not produce an increase in mutations when tested in the Ames Salmonella typhimurium assay with and without of metabolic activation. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: A log BCF of 1.72 (BCF = 53) for golden orfes and a BCF of 50 for golden ide fish (Leuciscus idus melanotus) was determined for n-dodecane after 3 days exposure(1,2). An estimated BCF upper limit of <240 L/kg was calculated for dodecane in fathead minnows in water at concentrations less than its maximum aqueous solubility(3). According to a classification scheme(4), these BCF values suggest that bioconcentration in aquatic organisms is moderate to high(SRC). The bioaccumulation factor of n-dodecane in algae (Chlorella fusca) was determined to be 6,250 after 1 day(1); a log BCF of 3.80 for green algae after 24 hours exposure was also determined(1). Only traces of n-dodecane were taken up by a marine diatom from crude oil(5). The bioaccumulation factor of n-dodecane in activated sludge was determined to be 1,300 after 5 days(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4800(SRC), determined from a structure estimation method(2), indicates that dodecane is expected to have slight mobility in soil(SRC). Volatilization of dodecane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.2 atm-cu m/mole(3) derived from its vapor pressure, 0.135 mm Hg(4), and water solubility, 3.7X10-3 mg/L(5). Dodecane is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). However, adsorption to soil is expected to attenuate volatilization. According to the Japanese MITI test, dodecane is considered readily biodegradable based on results of analogous chemicals(6) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4800(SRC), determined from a structure estimation method(2), indicates that dodecane is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 8.2 atm-cu m/mole(SRC), derived from its vapor pressure, 0.135 mm Hg(4), and water solubility, 3.7X10-3 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hrs and 5 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 32 days if adsorption is considered(6). According to a classification scheme(7), BCF values of 53(8) to <240(9) suggest bioconcentration in aquatic organisms is moderate to high(SRC). According to the Japanese MITI test, dodecane is considered readily biodegradable based on results of analogous chemicals(10) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dodecane, which has a vapor pressure of 0.135 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dodecane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 0.8 days(SRC), calculated from its rate constant of 1.4X10-11 cu cm/molecule-sec at 25 °C(3). Dodecane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Fuel; Processing aids not otherwise specified; Lubricating agent; Other; Solvent; Intermediate; Heat stabilizer; Not Known or Reasonably Ascertainable; Cleaning agent Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used as a solvent (inks and degreasing) and in chemical research and production; Used in paper processing; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Pulp and Paper Processing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Solvent, organic synthesis, distillation chaser, jet fuel research Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Manufacturing paraffin products ... Lubricant oil additive. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Dodecane is a component of gasoline and is used as solvent, in organic synthesis, in jet fuel research, as a distillation chaser, and in the rubber and paper processing industries. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: We have recommended surrogate blends for Fischer-Tropsch (F-T) blends that consist of mixtures of n-dodecane, n-decane, and iso-octane. In addition, we have described a systematic approach to generating a specific blend to match a specific fuel. Compositions for specific surrogates of two different F-T fuels have been proposed that provide a best match to cetane number, H/C ratio, lower heating value, T50 boiling point, and chemical-analysis data. Tests of these blends against experimental data for flame-propagation and flame-extinction strain rate show good agreement. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for n-Dodecane (11 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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2. Review restrictions

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3. Verify the formula

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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