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InventoryRef 3979702/03/2011

DODECANE

Dodecane

DODECANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 112-40-3
CAS 112-40-3PubChem CID 8182

Dodecane

dodecane has been reported in Camellia sinensis, Aristolochia triangularis, and other organisms with data available. — LOTUS - the natural products occurrence database

IUPAC name
dodecane
Molecular formula
C12H26
Molecular weight
170.33 g/mol
Exact mass
170.203450829 Da
XLogP3
6.1
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

n-DodecaneDihexylBihexylAdakane 12N-DodecanDuodecaneBa 51-09045311A386X1QH
16 more reported names
NSC-8714CHEBI:28817RefChem:5775203-967-9dodecanNSC 8714Dodecane(mixture of isomers)Undecane, methyl-n-Dodecan [German]Hydrocarbons, C4,1,3-butadiene-free, polymd., triisobutylene fraction, hydrogenatedD12CCRIS 661HSDB 5133EINECS 203-967-9BRN 1697175Dodekan
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8182

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: If any of your personnel should inhale this substance you should remove them immediately to open air. If symptoms develop, seek medical attention.; INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 0.4% (4 of 1042) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H304 (57.2%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H319 (43.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P280, P301+P316, P305+P351+P338, P331, P337+P317, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1042 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 4 of 1042 reports by companies.; There are 10 notifications provided by 1038 of 1042 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 4.2% (36 of 853) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (95.7%): Flammable liquid and vapor [Warning Flammable liquids]; H304 (95.8%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H410 (12.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H413 (19%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P273, P280, P301+P316, P303+P361+P353, P331, P370+P378, P391, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 853 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 36 of 853 reports by companies.; There are 8 notifications provided by 817 of 853 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P280, P301+P316, P331, P370+P378, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Dodecane is a colorless liquid. Dodecane is a component of gasoline and is used as solvent, in organic synthesis, in jet fuel research, as a distillation chaser, and in the rubber and paper processing industries. HUMAN EXPOSURE AND TOXICITY: Dodecane may be harmful if inhaled, swallowed, or absorbed through the skin. It can be irritating to mucous membranes. ANIMAL STUDIES: Dodecane, can produce slight to severe dermal irritation and respiratory in animals. However, it produced only minimal to negligible ocular irritation. Rats exposed to inhalation to 0.2 mL dodecane died within 24 hours of progressive edema and hemorrhaging. Dodecane did not show any effects, including no central nervous system depression, when rats were exposed at the saturated vapor concentrations. Dodecane, applied topically to progeny of rats treated with benzo(a)pyrene, chrysene, or benzo(b)triphenylene on gestation day 1, produced tumors in offspring. Dodecane has been shown to be a promoter of skin carcinogenesis for ultraviolet radiation. Dodecane, did not produce an increase in mutations when tested in the Ames Salmonella typhimurium assay with and without of metabolic activation. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: A log BCF of 1.72 (BCF = 53) for golden orfes and a BCF of 50 for golden ide fish (Leuciscus idus melanotus) was determined for n-dodecane after 3 days exposure(1,2). An estimated BCF upper limit of <240 L/kg was calculated for dodecane in fathead minnows in water at concentrations less than its maximum aqueous solubility(3). According to a classification scheme(4), these BCF values suggest that bioconcentration in aquatic organisms is moderate to high(SRC). The bioaccumulation factor of n-dodecane in algae (Chlorella fusca) was determined to be 6,250 after 1 day(1); a log BCF of 3.80 for green algae after 24 hours exposure was also determined(1). Only traces of n-dodecane were taken up by a marine diatom from crude oil(5). The bioaccumulation factor of n-dodecane in activated sludge was determined to be 1,300 after 5 days(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4800(SRC), determined from a structure estimation method(2), indicates that dodecane is expected to have slight mobility in soil(SRC). Volatilization of dodecane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.2 atm-cu m/mole(3) derived from its vapor pressure, 0.135 mm Hg(4), and water solubility, 3.7X10-3 mg/L(5). Dodecane is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). However, adsorption to soil is expected to attenuate volatilization. According to the Japanese MITI test, dodecane is considered readily biodegradable based on results of analogous chemicals(6) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4800(SRC), determined from a structure estimation method(2), indicates that dodecane is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 8.2 atm-cu m/mole(SRC), derived from its vapor pressure, 0.135 mm Hg(4), and water solubility, 3.7X10-3 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hrs and 5 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 32 days if adsorption is considered(6). According to a classification scheme(7), BCF values of 53(8) to <240(9) suggest bioconcentration in aquatic organisms is moderate to high(SRC). According to the Japanese MITI test, dodecane is considered readily biodegradable based on results of analogous chemicals(10) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dodecane, which has a vapor pressure of 0.135 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dodecane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 0.8 days(SRC), calculated from its rate constant of 1.4X10-11 cu cm/molecule-sec at 25 °C(3). Dodecane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Fuel; Processing aids not otherwise specified; Lubricating agent; Other; Solvent; Intermediate; Heat stabilizer; Not Known or Reasonably Ascertainable; Cleaning agent Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used as a solvent (inks and degreasing) and in chemical research and production; Used in paper processing; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Pulp and Paper Processing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Solvent, organic synthesis, distillation chaser, jet fuel research Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Manufacturing paraffin products ... Lubricant oil additive. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Dodecane is a component of gasoline and is used as solvent, in organic synthesis, in jet fuel research, as a distillation chaser, and in the rubber and paper processing industries. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: We have recommended surrogate blends for Fischer-Tropsch (F-T) blends that consist of mixtures of n-dodecane, n-decane, and iso-octane. In addition, we have described a systematic approach to generating a specific blend to match a specific fuel. Compositions for specific surrogates of two different F-T fuels have been proposed that provide a best match to cetane number, H/C ratio, lower heating value, T50 boiling point, and chemical-analysis data. Tests of these blends against experimental data for flame-propagation and flame-extinction strain rate show good agreement. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for n-Dodecane (11 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DODECANE

INCI name

DODECANE

Description

Dodecane

Record provenance

Inventory reference
39797
Imported identity
DODECANE
Source update
02/03/2011
European Commission CosIng source notes
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Key data

CAS
112-40-3
EC
203-967-9
Restriction
—
Function
PERFUMING
Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9575 · DODECANE

Ingredients with overlapping formulation functions

DOCOSANEPERFUMING
DODECAHYDRO-TETRAMETHYL-EPOXYNAPHTHOXEPINPERFUMING
DODECAHYDRO-TETRAMETHYLNAPHTHOFURANPERFUMING
DODECAHYDROCYCLODODECAFURANPERFUMING
DODECANENITRILEPERFUMING
DODECENE HYDROFORMYLATION PRODUCTSPERFUMING
ECHINACEA PURPUREA FLOWER OILFRAGRANCE; PERFUMING; SKIN CONDITIONING - MISCELLANEOUS
EICOSANEFRAGRANCE, PERFUMING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How DODECANE appears in the CosIng inventory

The CosIng inventory lists DODECANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DODECANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DODECANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DODECANE carries the following function designation(s):

CAS 112-40-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for DODECANE

This page reproduces the CosIng inventory entry for DODECANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DODECANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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